2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Pyruvate Carboxylase (PC)
  5. Pyruvate Carboxylase (PC) Inhibitor

Pyruvate Carboxylase (PC) Inhibitor

Pyruvate Carboxylase (PC) Inhibitors (4):

Cat. No. Product Name Effect Purity
  • HY-142870
    ZY-444
    		Inhibitor 99.51%
    ZY-444 is an anti-cancer agent, targeting pyruvate carboxylase (PC). ZY-444 suppresses the Wnt/β-catenin/Snail signaling pathway by blocking nuclear translocation of β-catenin. ZY-444 selectively inhibits proliferation, migration, and invasion and induces apoptosis in cancer cells. ZY-444 exhibits potent anti-tumor in cancer mouse models. ZY-444 can be used for the study of breast cancer, lung cancer (NSCLC), prostate cancer and iodine-refractory thyroid cancer.
  • HY-163771
    Pyruvate Carboxylase-IN-5
    		Inhibitor
    Pyruvate Carboxylase-IN-5 (compound 6m) is a pyruvate carboxylase inhibitor with high selectivity and permeability. Pyruvate carboxylase is a mitochondrial enzyme that catalyzes the carboxylation of pyruvate to oxaloacetate, a process that plays an important role in maintaining steady-state levels of Krebs cycle intermediates, which are precursors for the synthesis of biomacromolecules such as amino acids, fatty acids, and glucose.
  • HY-161680
    Pyruvate Carboxylase-IN-4
    		Inhibitor
    Pyruvate Carboxylase-IN-4 (Compd 8V) is a potent and competitive Pyruvate Carboxylase inhibitor with an IC50 of 4.3 μM.
  • HY-178040
    Insecticidal agent 26
    		Inhibitor
    Insecticidal agent 26 (Compound A11), a spiro insecticidal agent, is a dual-functional inhibitor of pest Acetyl-CoA carboxylase (ACC) and Pyruvate carboxylase (PC). Insecticidal agent 26 has potent insecticidal activity against Sogatella furcifera with a LC50 of 11.0  μg/mL, with significant biosafety to bees. Insecticidal agent 26 can be used for management of white-backed planthoppers (WBPs).