2. Signaling Pathways
  3. GPCR/G Protein
  4. Prokineticin Receptor
  5. Prokineticin Receptor Antagonist

Prokineticin Receptor Antagonist

Prokineticin Receptor Antagonists (4):

Cat. No. Product Name Effect Purity
  • HY-147056
    PKRA83
    		Antagonist 98.95%
    PKRA83 (PKRA7) is a potent prokineticin (PK2) antagonist, which can compete for the binding of PK2 to its receptors PKR1 and PKR2. PKRA83 potently inhibits PK2 receptors, with IC50 values of 5.0 nM and 8.2 nM for PKR1 and PKR2, respectively. PKRA83 has anticancer, anti-arthritis and anti-angiogenic activities. PKRA83 can penetrate the blood-brain barrier.
  • HY-147056B
    PKRA83 hydrochloride
    		Antagonist
    PKRA83 (PKRA7) hydrochloride is a potent, blood-brain-penetrating PK2 antagonist that competes for PK2 binding to its receptors, PKR1 and PKR2. PKRA83 hydrochloride potently inhibits PK2 receptors with IC50 values of 5.0 nM and 8.2 nM for PKR1 and PKR2, respectively. PKRA83 hydrochloride exhibits anticancer, antiarthritis, and antiangiogenic activities.
  • HY-129317
    A457
    		Antagonist
    A457 is a prokineticin receptor PKR2 antagonist, with an IC50 of 102 nM. A457 can rescue the cell surface expression and function of P290S PKR2, but not W178S and G234D PKR2.
  • HY-159972
    PKR1 antagonist 1
    		Antagonist
    PKR1 antagonist 1 (PC1) is a potent PKR1 antagonist. PKR1 antagonist 1 reduces hyperalgesia and allodynia in SNI mice.