2. Signaling Pathways
  3. PI3K/Akt/mTOR
  4. PIN1

PIN1

peptidylprolyl cis/trans isomerase, NIMA-interacting 1

PIN1 is a peptidyl-prolyl isomerase (PPIase) that specifically recognizes the pSer/Thr-Pro motif, catalyzes the cis and trans isomerization of the proline amide bond, changes the conformation of the substrate protein, thereby affecting its function, stability or intracellular localization. PIN1 regulates cell cycle proteins such as cyclin D, cyclin E, and CDC25, thereby regulating the G1-S process and mitotic progression. PIN1 regulates the stability of proteins such as p53 and p73, responds to stress signals such as DNA damage, and thus affects cell cycle arrest or apoptosis. PIN1 regulates the phosphorylation of tau protein, mediating the neurological functions. PIN1 regulates transcription factors such as NF-κB and JUN, mediates immune responses. PIN1 dysfunction could lead to Alzheimer's disease, cancer, asthma, or microbial infection[1][2].

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-171442A
    (R)-PIN1 ligand-2
    (R)-PIN1 ligand-2 is a PIN1 ligand, and can be used for synthesis of PROTACs, such as P1D-34 (HY-171334A).
    (R)-PIN1 ligand-2
  • HY-W843265
    PIN1 inhibitor 6
    		Inhibitor
    PIN1 inhibitor 6 (compound 38) is a Pin1 inhibitor. PIN1 inhibitor 6 can be utilized in cancer research.
    PIN1 inhibitor 6
Cat. No. Product Name / Synonyms Application Reactivity