2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. PI5P4K
  5. PI5P4K Degrader

PI5P4K Degrader

PI5P4K Isoform Comparison

PI5P4K Degrader (1):

Cat. No. Product Name Effect Purity
  • HY-175751
    LRK-4189
    		Degrader
    LRK-4189 (Compound 319) is an orally active and selective PIP4K2C PROTAC degrader with a DC50 < 500 nM for PIP4K2C in MOLT-4 cells. LRK-4189 has an antitumor activity and induces intrinsic cell death and activates interferon signaling, therefore triggering immune-mediated tumor killing in immune-inert microsatellite stable (MSS) CRC cells. LRK-4189 can be used for cancers like MSS colorectal carcinoma research.