2. Signaling Pathways
  3. GPCR/G Protein
  4. Orphan Receptor

Orphan Receptor

 

Orphan Receptor Related Products (35):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-161115
    NR2E3 agonist 1
    		Agonist 99.48%
    NR2E3 agonist 1 (Compound 11a) is a small molecule agonist of the photoreceptor-specific nuclear receptor (NR2E3) with an EC50 value of less than 200 nM. NR2E3 agonist 1 can be used in retinitis pigmentosa research.
    NR2E3 agonist 1
  • HY-131445A
    SS-RJW100
    		Agonist 99.91%
    SS-RJW100 is a enantiomer of RJW100, which is a racemic agonist of nuclear receptor liver receptor homolog 1 (LRH-1) and steroidogenic factor 1 (SF-1). SS-RJW100 promotes recruitment of coregulator protein fragments in vitro, recruits the transcriptional intermediary factor 2 (Tif2) coactivator to LRH-1. SS-RJW100 diminishes LRH-1 allosteric activation networks, shows poor thermal stability.
    SS-RJW100
  • HY-156190
    NR2F2-IN-1
    		Inhibitor
    NR2F6 modulator-2 (CIA1) is a potent and selective orphan nuclear receptor COUP-TFII (NR2F2) inhibitor. NR2F6 modulator-2 substantially inhibits COUP-TFII–driven NGFIA reporter expression. NR2F6 modulator-2 directly binds to the COUP-TFII ligand-binding domain and disrupts COUP-TFII interaction with transcription regulators, including FOXA1, thus repressing COUP-TFII activity on target gene regulation.
    NR2F2-IN-1
  • HY-109869
    Photoregulin1
    		Modulator
    Photoregulin1 is a compound with the potential to inhibit retinitis pigmentosa that modulates gene expression in retinal cells and slows the degeneration of photoreceptors in a mouse model.
    Photoregulin1
  • HY-P4414
    (Des-Bromo)-Neuropeptide B (1-23) (human)
    		Agonist
    (Des-Bromo)-Neuropeptide B (1-23) (human) is an orphan G-protein coupled receptor agonist with Kis of 1.2 nM and 341 nM for GPR7 (NPBW1) and GPR8 (NPBW2), respectively.
    (Des-Bromo)-Neuropeptide B (1-23) (human)
  • HY-118054
    LRH-1 Inhibitor-3
    		Inhibitor
    LRH-1 Inhibitor-3 is a small molecule that inhibits LRH-1 transcriptional activity, thereby decreasing the expression of target genes associated with cell growth and proliferation. LRH-1 Inhibitor-3 has shown potential in reducing cancer cell proliferation in human pancreatic, colon, and breast adenocarcinoma cell lines. LRH-1 Inhibitor-3 serves as a molecular probe for investigating the role of LRH-1 in various malignancies.
    LRH-1 Inhibitor-3
  • HY-148259
    SF-1 antagonist-1
    		Antagonist
    SF-1 antagonist-1 (compound 11) is a antagonist of steroidogenic factor 1 (SF-1). SF-1 antagonist-1 affects SF-1 transcriptional activity with an EC50 value of ＜200 nM. SF-1 antagonist-1 inhibits the proliferation of Rat Leydig tumor cells. SF-1 antagonist-1 can be used for the research of cancer.
    SF-1 antagonist-1
  • HY-164814
    GPR27 agonist-1
    		Agonist
    GPR27 Agonist-1 (compound I) is a selective GPR27 agonist with pEC50 of 6.34.
    GPR27 agonist-1
  • HY-148608
    LysoPalloT-NH-amide-C3-ph-m-O-C11
    		Agonist
    LysoPalloT-NH-amide-C3-ph-m-O-C11 is an agonist for GPR174 with an EC50 of 34 nM.
    LysoPalloT-NH-amide-C3-ph-m-O-C11
  • HY-168051
    TLX agonist 2
    		Agonist
    TLX agonist 2 (compound 31) is a TLX agonist (EC50=0.1 μM; Kd=0.16 μM). TLX agonist 2 promotes TLX transcriptional activity and enhances the expression of TLX target genes by binding to TLX. TLX agonist 2 can be used in the study of neurodegenerative diseases.
    TLX agonist 2
  • HY-169907
    Anticancer agent 258
    Anticancer agent 258 is an imidazo [1,2-B][1,2,4] triazol derivative. Anticancer agent 258 regulates the activity of nuclear receptors. Anticancer agent 258 has an EC50 of 63 nM against Nurr in N2A cells. Anticancer agent 258 has IC50 of 0.1 pM for Nur77 in HEK293 cells. Anticancer agent 258 can be used in the study of cancer, metabolic diseases and neurological disorders.
    Anticancer agent 258
  • HY-159920
    PSB-22269
    		Antagonist
    PSB-22269 is a GPR17 antagonist with a Ki value of 8.91 nM. PSB-22269 further demonstrated significant inhibitory effects in cAMP and G protein activation assays. Molecular docking studies revealed that the binding site of PSB-22269 contains positively charged arginine residues and a hydrophobic pocket. PSB-22269 provides a strategy to promote remyelination and holds promise for research in the field of multiple sclerosis.
    PSB-22269
  • HY-155168
    Iso-RJW100
    		Agonist
    Iso-RJW100 (compound 24-endo) is a dual-liver receptor homologue-1 (LRH-1) and steroidogenic factor-1 (SF-1) agonist with pEC50 of 6.4 and 7.2, respectively.
    Iso-RJW100
  • HY-B1058A
    Benfluorex
    		Agonist
    Benfluorex (JP-992) is a hepatic nuclear factor 4 alpha (HNF4α) activator.
    Benfluorex
  • HY-138291
    Ethoxyquin dimer
    		98.70%
    Ethoxyquin dimer is a dimer of Ethoxyquin (HY-B1425). Ethoxyquin dimer is an antioxidant. Ethoxyquin dimer can more readily accumulate in liver and adipose tissue compared with Ethoxyquin. Ethoxyquin above 10 mg/kg shows hepatotoxicity in mice.
    Ethoxyquin dimer