2. Signaling Pathways
  3. Vitamin D Related/Nuclear Receptor
  4. Orphan Nuclear Receptor
  5. Orphan Nuclear Receptor Agonist

Orphan Nuclear Receptor Agonist

Orphan Nuclear Receptor Agonists (8):

Cat. No. Product Name Effect Purity
  • HY-B1058
    Benfluorex hydrochloride
    		Agonist 99.85%
    Benfluorex hydrochloride (JP-992 hydrochloride) is a hepatic nuclear factor 4 alpha (HNF4α) activator.
  • HY-161115
    NR2E3 agonist 1
    		Agonist 99.48%
    NR2E3 agonist 1 (Compound 11a) is a small molecule agonist of the photoreceptor-specific nuclear receptor (NR2E3) with an EC50 value of less than 200 nM. NR2E3 agonist 1 can be used in retinitis pigmentosa research.
  • HY-148608
    LysoPalloT-NH-amide-C3-ph-m-O-C11
    		Agonist
    LysoPalloT-NH-amide-C3-ph-m-O-C11 is an agonist for GPR174 with an EC50 of 34 nM.
  • HY-164814
    GPR27 agonist-1
    		Agonist
    GPR27 Agonist-1 (compound I) is a selective GPR27 agonist with pEC50 of 6.34.
  • HY-168051
    TLX agonist 2
    		Agonist
    TLX agonist 2 (compound 31) is a TLX agonist (EC50=0.1 μM; Kd=0.16 μM). TLX agonist 2 promotes TLX transcriptional activity and enhances the expression of TLX target genes by binding to TLX. TLX agonist 2 can be used in the study of neurodegenerative diseases.
  • HY-B1058A
    Benfluorex
    		Agonist
    Benfluorex (JP-992) is a hepatic nuclear factor 4 alpha (HNF4α) activator.
  • HY-176136
    HNF4 agonist 1
    		Agonist
    HNF4 agonist 1 (compound 46) is a potent HNF4 agonist. HNF4 agonist 1 activates HNF4α and HNF4γ with EC50s of 6 and 17 nM, respectively. HNF4 agonist 1 can be used in the study of maturity-onset diabetes of the young 1 (MODY-1).
  • HY-B1058R
    Benfluorex hydrochloride (Standard)
    		Agonist
    Benfluorex (hydrochloride) (Standard) is the analytical standard of Benfluorex (hydrochloride). This product is intended for research and analytical applications. Benfluorex hydrochloride (JP-992 hydrochloride) is a hepatic nuclear factor 4 alpha (HNF4α) activator.