2. Signaling Pathways
  3. GPCR/G Protein
  4. Orphan GPCR
  5. Orphan GPCR Agonist

Orphan GPCR Agonist

Orphan GPCR Agonist (1):

Cat. No. Product Name Effect Purity
  • HY-N15721
    Tryptophan-cholic acid
    		Agonist
    Tryptophan-cholic acid (Trp-CA) is a microbial amino-acid-conjugated bile acid, serving as an endogenous ligand and agonist of the orphan G protein-coupled receptor (GPCR) MRGPRE. Tryptophan-cholic acid activates MRGPRE, promoting the secretion of glucagon-like peptide-1 (GLP-1) through the Gs-cAMP and β-arrestin-1-ALDOA signaling pathways, thereby improving glucose tolerance in diabetic mice. Tryptophan-cholic acid is promising for research of type 2 diabetes.