2. Signaling Pathways
  3. Cell Cycle/DNA Damage
  4. NEKs
  5. NEKs Isoform
  6. NEKs Degrader

NEKs Degrader

NEKs Degraders (3):

Cat. No. Product Name Effect Purity
  • HY-173154A
    NK7-902 TFA
    		Degrader 98.86%
    NK7-902 TFA is a CRBN molecular glue degrader of NEK7. NK7-902 TFA fully degrades NEK7 in human primary monocytes and whole blood but only partially inhibits NLRP3-dependent IL-1β production. NK7-902 TFA leads to profound and long-lasting NEK7 degradation but only transiently blocks NLRP3 inflammasome activation in non-human primates by oral administration. NK7-902 TFA shows activity in murine systems.
  • HY-175283
    ABT-002
    		Degrader
    ABT-002 is a molecular glue degrader targeting GSPT1 and NEK7. ABT-002 is promising for research of hepatocellular carcinoma (HCC).
  • HY-W599279
    ABS-752
    		Degrader
    ABS-752 is a potent and orally active GSPT1 and NEK7 molecular glue degrader. ABS-752 shows cytotoxicity. ABS-752 decreases the protein expression of GSPT1 and SALL4, NEK7. ABS-752 shows anticancer activity. ABS-752 has the potential for the research of hepatocellular carcinoma.