2. Signaling Pathways
  3. Cell Cycle/DNA Damage
  4. NEKs
  5. NEKs Isoform
  6. NEKs Degrader

NEKs Degrader

NEKs Degrader (1):

Cat. No. Product Name Effect Purity
  • HY-173154
    NK7-902
    		Degrader
    NK7-902 is a CRBN molecular glue degrader of NEK7. NK7-902 fully degrades NEK7 in human primary monocytes and whole blood but only partially inhibits NLRP3-dependent IL-1β production. NK7-902 leads to profound and long-lasting NEK7 degradation but only transiently blocks NLRP3 inflammasome activation in non-human primates by oral administration. NK7-902 shows activity in murine systems.