Liposome

Liposomes (NPs typically 100–500 nm in diameter) are fabricated from the self-assembly of phospholipids, which consist of a polar phosphate head group and hydrophobic lipid tails. In aqueous environments, the hydrophobic tails self-orient, resulting in a spherical structure comprised of an aqueous core surrounded by a lipophilic bilayer membrane. Liposomes are both biocompatible and biodegradable (e.g., at certain pH and temperature), which can be controlled by modifying the lipid composition. Furthermore, liposomes are amenable to various modifications that improve their efficacy as drug delivery carriers.

References:

[1]. Almeida B, Nag OK, Rogers KE, Delehanty JB. Recent Progress in Bioconjugation Strategies for Liposome-Mediated Drug Delivery. Molecules. 2020;25(23):5672. Published 2020 Dec 1. [Content Brief]

Liposome Related Products (839):

By Effects:	Controls (2) Inhibitor (1) Substrate (1) Modulator (1) Chemicals (8)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-142989

1,2-Didocosahexaenoyl-sn-glycero-3-phosphocholine		≥98.0%
1,2-Didocosahexaenoyl-sn-glycero-3-phosphocholine is a polyunsaturated phospholipid that is a constituent of lipid monolayers and small unilamellar vesicles. 1,2-Didocosahexaenoyl-sn-glycero-3-phosphocholine can be used to prepare endoplasmic reticulum-targeted liposomes (PERLs) in a molar ratio of 1.5:1.5:1:1 with 1,2-didocosahexaenoyl-sn-glycero-3-phosphoethanolamine, l-α-phosphatidylinositol, and l-α-phosphatidylserine. PERLs can reduce cholesterol levels in human peripheral blood mononuclear cells (PBMCs) and reduce HIV-1 particle secretion from HIV-1 infected PBMCs.

HY-139306

BAMEA-O16B		≥98.0%
BAMEAO16B is a lipid nanoparticle. BAMEAO16B integrated with disulfide bonds, can efficiently deliver Cas9 mRNA and sgRNA into cells while releasing RNA in response to the reductive intracellular environment for genome editing. BAMEAO16B can be used for the research of gene editing.

HY-W590549

Dioleyldimethylammonium chloride
Dioleyldimethylammonium chloride (DODAC) is a cationic lipid that can be used as transfection reagent.

HY-148488

A18-Iso5-2DC18
A18-Iso5-2DC18 (Compound A18) is a cyclic lipidoid. A18-Iso5-2DC18 partially activates STING. A18-Iso5-2DC18 promotes mRNA protein expression and induces a strong immune response. A18-Iso5-2DC18 can be used in melanoma research.

HY-170035

GlcCer (d18:1/18:0)		99.58%
GlcCer (d18:1/18:0) (C18 Glucosyl(β) ceramide (d18:1/18:0)) is a glycosphingolipid. GlcCer (d18:1/18:0) is promising for research of Parkinson disease and dementia with Lewy bodies.

HY-162543

18:1 Liss Rhod PE		99%
18:1 Liss Rhod PE (18:1 Lissamine rhodamine PE) is a fluorescently labeled lipid. It can be used to label giant monolayer vesicles and DOPC.

HY-W440719

Cholesterol-PEG-MAL (MW 2000)
Cholesterol-PEG-MAL (MW 2000) is a PEG derivative and can be used to prepare liposome or nanoparticle due to its ability to self-assemble in water. The maleimide moiety is reactive with thiol molecule to form a covalent thioether bond.

HY-156197

Biotin-cholesterol
Biotin-cholesterol is a biotinylated form of Cholesterol (HY-N0322). Biotin-cholesterol can be used in the synthesis of biotin-conjugated liposomes and micelles for drug delivery.

HY-156448

80-O14B		99.56%
80-O14B is a cationic lipid-like compound. 80-O14B can be used in mRNA delivery studies.

HY-142990

1-Oleoyl-2-palmitoyl-sn-glycero-3-PC		99.80%
1-Oleoyl-2-palmitoyl-sn-glycero-3-PC derives from an oleic acid. 1-Oleoyl-2-palmitoyl-sn-glycero-3-PC can be used for the synthesis of liposomes.

HY-145794

ZA3-Ep10		≥98.0%
ZA3-Ep10 is a zwitterionic lipid used in lipid nanoparticles formulation for in vivo RNA delivery.

HY-134782

OF-Deg-Lin
OF-Deg-Lin is an ionizable amino lipid used for the generation of Lipid nanoparticles (LNPs).

HY-W099547

Dihexadecyl hydrogen phosphate		99.91%
Dihexadecyl hydrogen phosphateIt is an organic compound belonging to phospholipids. It's often used as an emulsifier, which means it helps mix two substances together that don't usually mix well, such as oil and water. Dihexadecyl hydrogen phosphateIt has several applications in the food industry, especially in the production of processed foods where it improves texture and stability. Additionally, it has applications in the pharmaceutical industry where it can be used ain the generation of micelles, liposomes, and other types of artificial membranes.

HY-W440890

DSPE-PEG-Folate, MW 5000
DSPE-PEG-Folate, MW 5000 is a PEG derivative containing folic acid. DSPE-PEG-Folate, MW 5000 has a targeting effect and bind to folate receptors in cancer cells. DSPE-PEG-Folate, MW 5000 form micelles/lipid bilayer and can be used to targeted drug delivery system research.

HY-139305

CL4H6
CL4H6 is a pH-sensitive cationic lipid. CL4H6 is the main component of lipid nanoparticles (LNPs), which can be used to target and deliver siRNA, and induces a potent gene-silencing response.

HY-148049

TT3		98.0%
TT3 is an ionizable lipid-like material and a lipid nanoparticle (LLNs)-based mRNA delivery vector. TT3 exhibits liver and spleen specificity and excellent delivery efficiency.

HY-W440827

DOPE-PEG-COOH (MW 2000)
DOPE-PEG-COOH (MW 2000) is a PEG polymer containing unsaturated DOPE phospholipids and carboxylic acids. DOPE-PEG-COOH (MW 2000) can be used to prepare liposomes or other nanoparticles for drug delivery.

HY-151509

A2-Iso5-2DC18
A2-Iso5-2DC18 is a dihydroimidazole-linked lipid, served as potent mRNA delivery vehicle. A2-Iso5-2DC18 can be used for antitumor research, including B16F10 melanoma..

HY-W440982

SOPC		98.0%
SOPC is an asymmetrical phospholipid with saturated fatty acid (stearic acid/18:0) at sn-1 position and unsaturated fatty acid (oleic acid/18:1) at sn-2 position. SOPC can be used for various biochemical studies.

HY-W322575

1,2-Diheptadecanoyl-sn-glycero-3-phosphorylcholine		99.0%
1,2-Diheptadecanoyl-sn-glycero-3-phosphorylcholine (DHPC) is a biologically active phospholipid compound and a derivative of phosphatidylcholine (PC). It can be used in the generation of micelles, liposomes, and other types of artificial membranes.

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