2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Liposome

Liposome

Liposomes (NPs typically 100–500 nm in diameter) are fabricated from the self-assembly of phospholipids, which consist of a polar phosphate head group and hydrophobic lipid tails. In aqueous environments, the hydrophobic tails self-orient, resulting in a spherical structure comprised of an aqueous core surrounded by a lipophilic bilayer membrane. Liposomes are both biocompatible and biodegradable (e.g., at certain pH and temperature), which can be controlled by modifying the lipid composition. Furthermore, liposomes are amenable to various modifications that improve their efficacy as drug delivery carriers.

Liposome Related Products (825):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-112772A
    98N12-5
    		≥98.0%
    98N12-5 is a novel multi-tail ionizable lipids that has been used for efficient in vivo siRNA-delivery to the liver.
    98N12-5
  • HY-145742
    1,2-Distearoyl-sn-Glycero-3-Phosphatidylglycerol sodium
    		≥98.0%
    1,2-Distearoyl-sn-Glycero-3-Phosphatidylglycerol (sodium) is the component of liposomes for drug delivery.
    1,2-Distearoyl-sn-Glycero-3-Phosphatidylglycerol sodium
  • HY-143702
    Fluorescent DOTAP
    Fluorescent DOTAP (NBD-DOTAP) is a cationic lipid which can be used for nucleic acid and protein delivery. Fluorescent DOTAP is labeled with a fluorophore NBD (maximum excitation/emission wavelength ∼463/536 nm). Fluorescent DOTAP can be used for gene delivery systems, drug delivery, as well as cell imaging and nanocarrier tracking. Fluorescent DOTAP is an ideal candidate for both biological and pharmaceutical formulation (e.g. co-delivery of vaccines) research.
    Fluorescent DOTAP
  • HY-156857
    PPZ-A10
    		Chemical ≥98.0%
    PPZ-A10 is a ionizable lipid that delivered mRNA preferentially to liver and spleen immune cells.
    PPZ-A10
  • HY-112768
    PEG2000-DMPE
    		Chemical 99.70%
    PEG2000-DMPE can be used to synthsis a LNP. PEG2000-DMPE enhances the entrapment efficiency depending on the increasing portion in the liposome. The optimal formulation for animal study is that DMPC/PEG2000-DMPE/CH=50/5/45 at the weight ratio of drug/lipid=1/20.
    PEG2000-DMPE
  • HY-B1555
    Benzyl nicotinate
    		99.60%
    Benzyl nicotinate is a vasodilator that increases skin oxygenation levels by increasing skin blood flow.
    Benzyl nicotinate
  • HY-148648
    Lipid 29
    		99.87%
    Lipid 29 is an ionizable amino lipid. Lipid 29 can be used to form lipid nanoparticles.
    Lipid 29
  • HY-42990
    Hydrogenated soya phosphatidylcholine
    		99.00%
    Hydrogenated soya phosphatidylcholine (hydrogenated soybean phosphatidylcholine) is a natural product. Hydrogenated soya phosphatidylcholine can extend drug release in regard to drug loading and solubility for oral drug delivery of watersoluble drugs.
    Hydrogenated soya phosphatidylcholine
  • HY-150220
    1,5-Dihexadecyl N-(3-carboxy-1-oxopropyl)-L-glutamate
    1,5-Dihexadecyl N-(3-carboxy-1-oxopropyl)-L-glutamate is a lipid used in the synthesis of phospholipid vesicles. 1,5-Dihexadecyl N-(3-carboxy-1-oxopropyl)-L-glutamate works with other lipids to convert polydisperse vesicles into vesicles of uniform size by freeze-thaw and extrusion techniques. 1,5-Dihexadecyl N-(3-carboxy-1-oxopropyl)-L-glutamate can enhance protein encapsulation efficiency for drug delivery and biochemical applications.
    1,5-Dihexadecyl N-(3-carboxy-1-oxopropyl)-L-glutamate
  • HY-150118
    Lipid 8
    		≥98.0%
    Lipid 8 is an ionizable amino lipid that can be used to synthesize lipid nanoparticles (LNPs). Lipid 8 is applicable to research in drug delivery.
    Lipid 8
  • HY-153879
    C12-TLRa
    		≥99.0%
    C12-TLRa is an ionized adjuvant lipid. C12-TLRa targets TLR7/8 receptors in endosomes. C12-TLRa enhances mRNA delivery as a structural component of LNPs. C12-TLRa enhances innate immune responses. C12-TLRa can be used for the research of SARS-CoV-2 mRNA vaccine.
    C12-TLRa
  • HY-150115
    Lipid 10
    Lipid 10 is an ionizable amino lipid used for the generation of Lipid nanoparticles (LNPs).
    Lipid 10
  • HY-137499
    NT1-O12B
    NT1-O12B, an endogenous chemical and a neurotransmitter-derived lipidoid (NT-lipidoid), is an effective carrier for enhanced brain delivery of several blood-brain barrier (BBB)-impermeable cargos. Doping NT1-O12B into BBB-impermeable lipid nanoparticles (LNPs) gives the LNPs the ability to cross the BBB. NT-lipidoids formulation not only facilitate cargo crossing of the BBB, but also delivery of the cargo into neuronal cells for functional gene silencing or gene recombination.
    NT1-O12B
  • HY-W130610
    Stearamide
    Stearamide is a primary fatty acid amide. Stearamide displays cytotoxic and ichthytoxic activity.
    Stearamide
  • HY-137501
    306-O12B-3
    		99.87%
    306-O12B-3 is a lipidoid that can efficiently deliver ASO both in vitro and in vivo. 306-O12B-3 is used to transport small molecule drugs across the blood-brain barrier (BBB).
    306-O12B-3
  • HY-149167
    ATX-0126
    		99.94%
    ATX-0126 (ATX 100) is an ionizable lipid based on thiocarbamate. ATX-0126 can be involved in the formation of lipid nanoparticles and is used in research such as nucleic acid delivery.
    ATX-0126
  • HY-W440988
    DOPE-mPEG, MW 2000
    DOPE-mPEG, MW 2000 is a phospholipid polydisperse PEG (or DOPE liposome), can be used for preparation of targeted delivery of liposomal drug and giant unilamellar vesicles (GUVs). DOPE-mPEG, MW 2000 significantly reduces the pH-sensitivity of the liposome in a concentration dependent manner.
    DOPE-mPEG, MW 2000
  • HY-115415
    1,2-Distearoyl-sn-glycero-3-phosphate sodium
    		≥98.0%
    1,2-Distearoyl-sn-glycero-3-phosphate, sodium salt is a phospholipid commonly used as a component of liposome formulations and drug delivery systems. 1,2-Distearoyl-sn-glycero-3-phosphate, sodium salt has unique chemical properties that make it an effective tool for encapsulating drugs and delivering them to specific targets in the body. It acts as a stabilizer and emulsifier, which can improve the solubility and bioavailability of drugs.
    1,2-Distearoyl-sn-glycero-3-phosphate sodium
  • HY-153231
    eGFP mRNA-LNP
    eGFP mRNA-LNP is a lipid nanoparticle (LNP) containing eGFP mRNA. eGFP mRNA-LNP carries Enhanced Green Fluorescent Protein (eGFP), which will express green fluorescent protein after entering the cell. eGFP is commonly used as a reporter gene detectable by fluorescence microscopy or flow cytometry (excitation wavelength = 488 nm; emission wavelength = 535/40 bandpass). eGFP mRNA-LNP can be used for RNA delivery, translation efficiency and cell viability.
    eGFP mRNA-LNP
  • HY-22274
    DMPG sodium
    		99.16%
    DMPG sodium is a biochemical reagent. DMPG sodium is used as a liposome carrier to load 6-shogaol (HY-14616) with anticancer activity.
    DMPG sodium