2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Lipase

Lipase

Lipase is a water-soluble enzyme that can catalyze the ester bond hydrolysis of lipids, decompose and metabolize fat molecules. Lipase is produced primarily by the pancreas and helps the body digest fats and oils. Lipase inhibitors are able to reduce the digestion and absorption of fat, thereby reducing collective caloric intake and weight loss. Lipase inhibitors are commonly used to suppress diseases such as obesity, hyperlipidemia, and pancreatitis.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-N15385
    Hericenone D
    		Inhibitor
    Hericenone D is a lipase inhibitor that can be isolated and extracted from Hericium erinaceus. Hericenone D can be used in the research of obesity.
    Hericenone D
  • HY-N14643
    Panclicin C
    		Inhibitor
    Panclicin C is a potent pancreatic lipase inhibitor.
    Panclicin C
  • HY-N0555R
    Escin IB (Standard)
    		Inhibitor
    Escin IB (Standard) is the analytical standard of Escin IB. This product is intended for research and analytical applications. Escin IB is a saponin isolated from skin and the endosperm of seeds of horse chestnut (Aesculus hippocastanum). Escin IB shows inhibitory effect on pancreatic lipase activity.
    Escin IB (Standard)
  • HY-N14647
    Panclicin E
    		Inhibitor
    Panclicin E is a potent pancreatic lipase inhibitor.
    Panclicin E
  • HY-155836
    hPL-IN-1
    		Inhibitor
    hPL-IN-1 (compound 2t) is a reversible inhibitor of pancreatic lipase (PL) (IC50=1.86 μM) for anti-obesity research.
    hPL-IN-1
  • HY-N14646
    Panclicin D
    		Inhibitor
    Panclicin D is a potent pancreatic lipase inhibitor.
    Panclicin D
  • HY-N7859
    1,3-Dioleoyl-2-myristoyl glycerol
    1,3-Dioleoyl-2-myristoyl glycerol is a triacylglycerol that contains oleic acid at the sn-1 and sn-3 positions and myristic acid at the sn-2 position.
    1,3-Dioleoyl-2-myristoyl glycerol
  • HY-N14642
    Panclicin B
    		Inhibitor
    Panclicin B is a potent pancreatic lipase inhibitor.
    Panclicin B
  • HY-119741
    Salacinol
    		Inhibitor
    Salacinol can be isolated from the roots of the plant Salacia reticulata. Salacinol inhibits fat metabolizing enzymes, such as pancreatic lipase (PL, IC50=12.6 mg/L), lipoprotein lipase (LPL, IC50=13.6 mg/L), and glycerophosphate dehydrogenase (GPDH), enhances the lipolysis, and exhibits antiobesity efficacy in rats.
    Salacinol
  • HY-N14194
    Esterastin
    		Inhibitor
    Esterastin is a lipase inhibitor with an IC50 value of 2 ng/mL when p-nitrophenyl acetate is used as a substrate.
    Esterastin
  • HY-159656
    PNPLA3 modifier 1
    		Activator
    PNPLA3 modifier 1 (compound 10) is a Patatin-like phospholipase domain-containing protein 3 (pnpla3) modifier, with a geometric mean EC50 of 4.9 nM.
    PNPLA3 modifier 1
  • HY-157313
    Pancreatic lipase-IN-1
    		Inhibitor
    Pancreatic lipase-IN-1 (compound 8) ia a pancreatic lipase inhibitor with the Ki of 1.288 μM.
    Pancreatic lipase-IN-1
Cat. No. Product Name / Synonyms Application Reactivity