2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Lipase

Lipase

Lipase is a water-soluble enzyme that can catalyze the ester bond hydrolysis of lipids, decompose and metabolize fat molecules. Lipase is produced primarily by the pancreas and helps the body digest fats and oils. Lipase inhibitors are able to reduce the digestion and absorption of fat, thereby reducing collective caloric intake and weight loss. Lipase inhibitors are commonly used to suppress diseases such as obesity, hyperlipidemia, and pancreatitis.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-131999
    3,4,5-Trihydroxycinnamic acid decyl ester
    		Inhibitor 99.44%
    3,4,5-Trihydroxycinnamic acid decyl ester is an excellent inhibitor of lipid absorption and accumulation, with anti-obesity properties. 3,4,5-Trihydroxycinnamic acid decyl ester is a pancreatic lipase inhibitor, with an EC50 of approximately 0.9 μM.
    3,4,5-Trihydroxycinnamic acid decyl ester
  • HY-N0618
    Sanggenon D
    		Inhibitor 99.76%
    Sanggenon D is a Diels-Alder-type adduct from Chinese crude agent root bark of mulberry ( Morus alba L.). Sanggenon D possesses antioxidant and inhibits Pancreatic lipase (PL) with the an IC50 of 0.77 μM.
    Sanggenon D
  • HY-164714
    HSL-IN-5
    		Inhibitor 99.83%
    HSL-IN-5 (Example 21) is a hormone sensitive lipase (HSL) inhibitor (IC50: 0.25 μM). HSL-IN-5 can be used for diabetes research.
    HSL-IN-5
  • HY-112911
    Endothelial lipase inhibitor-1
    		Inhibitor 98.02%
    Endothelial lipase inhibitor-1 is a potent endothelial lipase inhibitor with an IC50 of 49 nM.
    Endothelial lipase inhibitor-1
  • HY-135996
    Dilaurylglycerosulfate
    Dilaurylglycerosulfate is a co-emulsifier in the diagnostic test for the determination of lipase.
    Dilaurylglycerosulfate
  • HY-Y1422I
    Lipase AK
    Lipase AK comes from Pseudomonas fluorescens and shows good applicability in ester synthesis of food industry, the biofuel synthesis, the synthesis of enantiomeric pure chiral drugs and so on.
    Lipase AK
  • HY-155837
    hPL-IN-2
    		Inhibitor 98.17%
    hPL-IN-2 (compound 2u) is a potent, reversible, and non-competitive inhibitor of pancreatic lipase (IC50: 1.63 μM) and can be used in anti-obesity research.
    hPL-IN-2
  • HY-N2330
    Lipstatin
    		Inhibitor
    Lipstatin is a pancreatic lipase inhibitor (IC50=0.14 μM), whose structure is closely related to the known inhibitor, Esterastin. Lipstatin inhibits the absorption of triglycerides without affecting the absorption of oleic acid. Lipstatin has no inhibitory effects on other pancreatic enzymes, such as phospholipase A2 and trypsin (<200 μM).
    Lipstatin
  • HY-Y1422E
    Lipase AS
    Lipase AS comes from Aspergillusniger and can be used for catalyzing chemical reactions.
    Lipase AS
  • HY-N12297
    Ciwujianoside C2
    		Activator
    Ciwujianoside C2 is a saponin, that can be isolated from the leaves of Acanthopanax senticosus. Ciwujianoside C2 enhances pancreatic lipase activity in vitro.
    Ciwujianoside C2
  • HY-126938
    4-Methylumbelliferyl heptanoate
    4-Methylumbelliferyl heptanoate is a potent fluorometric substrate of lipase.
    4-Methylumbelliferyl heptanoate
  • HY-N12292
    Acanthopanaxoside A
    		Inhibitor
    Acanthopanaxoside A, a triterpenoid saponin, has pancreatic lipase inhibitory action.
    Acanthopanaxoside A
  • HY-118481
    H-Pro-Glu-OH
    H-Pro-Glu-OH is a protein secreted by pathogenic mycobacteria through the Type VII secretion system. H-Pro-Glu-OH targets LipY lipases to the cell Surface via the ESX-5 Pathway.
    H-Pro-Glu-OH
  • HY-Y1422A
    Lipase, Human Pancreas
    Lipase, Human Pancreas (Pancreatic Triacylglycerol Lipase, PL, PTL, Pancreatic Lipase) is a biological material or organic compound that can be used in life science research.
    Lipase, Human Pancreas
  • HY-121517
    URB754
    		Inhibitor
    URB754 is a potent inhibitor of the endocannabinoid-deactivating enzyme monoacylglycerol lipase (MGL) with an IC50 of 200 nM.
    URB754
  • HY-165039
    1,3-Dioleoyl-2-octanoyl glycerol
    1,3-Dioleoyl-2-octanoyl glycerol (1,3-Olein-2-caprylin) is a triacylglycerol. 1,3-Dioleoyl-2-octanoyl glycerol can be used to characterize the functionality of R. oryzae lipase for regiodistribution analysis of fats containing medium- and short-chain fatty acids.
    1,3-Dioleoyl-2-octanoyl glycerol
  • HY-163959
    PF-07853578
    		Degrader
    PF-07853578 (Example 11) is a PNPLA3 degrader with an EC50 of 8 nM. PNPLA3 degrader-1 can be used in the study of cirrhosis and hepatocellular carcinoma.
    PF-07853578
  • HY-Y1422J
    Lipase PS-SD
    Lipase PS-SD comes from Burkholderiacepacia and can be used for catalytic reaction.
    Lipase PS-SD
  • HY-157733
    1,2-Dioleoyl-3-behenoylglycerol
    		Inhibitor
    1,2-Dioleoyl-3-behenoylglycerol (BOO) inhibits pancreatic lipase activity. 1,2-Dioleoyl-3-behenoylglycerol prevents the deposition of visceral fat and hepatic triacylglycerol (TAG).
    1,2-Dioleoyl-3-behenoylglycerol
  • HY-N12294
    Ciwujianoside D2
    		Inhibitor
    Ciwujianoside D2, a saponin compound, can enhance pancreatic lipase activity in vitro.
    Ciwujianoside D2
Cat. No. Product Name / Synonyms Application Reactivity