Isotope-Labeled Compounds

Isotope-labeled compounds are chemical substances in which some atoms in their molecules are replaced by isotope atoms. The range of stable isotope products can cover from gases to complex molecules. Isotope-labeled compounds could provide a site-specific investigation of structures, making molecules easily detectable by mass spectrometry and NMR, and maintaining the physico-chemical properties of the target molecule at the same time. MCE isotope-labeled compounds are all stable isotope-labeled compounds and are non-radioactive labeled substances. MCE isotope-labeled compounds are unique tools for identifying and understanding biological and chemical processes. Stable isotope-labeled products are now getting more and more popular among scientists. The scope of application is gradually penetrating into various scientific fields, such as life sciences, food and medicine, agriculture, environment, geology, etc. Stable isotope-labeled compounds have a wide range of applications in the Life Science areas, such as Metabolomics, Proteomics, Clinical studies, Deuterium drugs, etc.

Isotope-Labeled Compounds Inhibitors (4)

Isotope-Labeled Compounds Related Products (9716):

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-N0215S5

L-Phenylalanine-¹⁵N		98.10%
L-Phenylalanine-¹⁵N is the ¹⁵N-labeled L-Phenylalanine. L-Phenylalanine ((S)-2-Amino-3-phenylpropionic acid) is an essential amino acid isolated from Escherichia coli. L-Phenylalanine is a α2δ subunit of voltage-dependent Ca+ channels antagonist with a K_i of 980 nM. L-phenylalanine is a competitive antagonist for the glycine- and glutamate-binding sites of N-methyl-D-aspartate receptors (NMDARs) (KB of 573 μM ) and non-NMDARs, respectively. L-Phenylalanine is widely used in the production of food flavors and pharmaceuticals.

HY-W014375S2

Arginine-¹³C₆ hydrochloride		99.00%
Arginine-¹³C₆ hydrochloride is ¹³C-labeled Arginine (hydrochloride) (HY-W014375). Arginine hydrochloride is an arginine derivative.

HY-N0667S5

L-Asparagine-d₃ hydrate		99.64%
L-Asparagine-d₃ hydrate is the deuterium labeled L-Asparagine (HY-N0667). L-Asparagine is an essential amino acid for leukemic cells and a substrate for L-Asparaginase. L-Asparaginase is a potent anti-leukemic enzyme that promotes asparagine (Asn) and glutamine (Gln) depletion and inhibits protein biosynthesis in lymphoblasts. Removal of L-asparagine from plasma by L-Asparaginase results in inhibition of RNA and DNA synthesis and subsequent apoptosis. L-Asparaginase has cell-killing ability in vitro and in vivo, and selectively inhibits the growth of cancer cells with low asparagine synthetase (AASNS) expression. L-Asparagine can be used as a biomarker and sensor for the study of childhood acute lymphoblastic leukemia.

HY-B1727S

Phenanthrene-d₁₀
Phenanthrene-d₁₀ is the deuterium labeled Phenanthrene. Phenanthrene is a polycyclic aromatic hydrocarbon (PAH) and has been frequently used as an indicator for monitoring PAH contaminated matrices. Phenanthrene induces oxidative stress and inflammation.

HY-B0075S1

Melatonin-d₃		99.81%
Melatonin-d₃ is the deuterium labeled Melatonin. Melatonin is a hormone made by the pineal gland that can activates melatonin receptor. Melatonin plays a role in sleep and possesses important antioxidative and anti-inflammatory properties. Melatonin is a novel selective ATF-6 inhibitor and induces human hepatoma cell apoptosis through COX-2 downregulation. Melatonin attenuates palmitic acid-induced (HY-N0830) mouse granulosa cells apoptosis via endoplasmic reticulum stress.

HY-150642S

Guanosine-5 '- monophosphate-¹⁵N₅ sodium		99.50%
Guanosine-5 '- monophosphate-¹⁵N₅ (sodium) is the ¹⁵N labeled Guanosine-5 '- monophosphate sodium.

HY-143711S

Trimethyllysine-d₉
Trimethyllysine-d₉ is the deuterium labeled Trimethyllysine (HY-143711). Trimethyllysine is an important post-translationally modified amino acid, involving in carnitine biosynthesis and epigenetic processes.

HY-W450789S

Phenylmethan-d₂-ol		≥99.0%
Phenylmethan-d₂-ol is the deuterium labeled Phenylmethan-ol.

HY-10219S

Rapamycin-d₃
Rapamycin-d₃ is the deuterium labeled Rapamycin. Rapamycin is a potent and specific mTOR inhibitor with an IC₅₀ of 0.1 nM in HEK293 cells. Rapamycin binds to FKBP12 and specifically acts as an allosteric inhibitor of mTORC1. Rapamycin is an autophagy activator, an immunosuppressant.

HY-N7148S

α-Vitamin E-d₆		≥99.0%
α-Vitamin E-d₆ is the deuterium labeled α-Vitamin E.

HY-Y0001S

Cyclopropylcarboxylic acid-d₄		99.58%
Cyclopropylcarboxylic acid-d₄ is the deuterium labeled Cyclopropylcarboxylic acid.

HY-B2219S2

Stearic acid-¹³C₁₈		≥98.0%
Stearic acid-¹³C₁₈is the ¹³C-labeled Stearic acid. Stearic acid is a long chain dietary saturated fatty acid which exists in many animal and vegetable fats and oils.

HY-16562S1

Irinotecan-d₁₀ hydrochloride		99.76%
Irinotecan-d₁₀ (hydrochloride) is the deuterium labeled Irinotecan. Irinotecan ((+)-Irinotecan) is a topoisomerase I inhibitor, preventing religation of the DNA strand by binding to topoisomerase I-DNA complex.

HY-100805S

D-Glutamic acid-d₅		99.91%
D-Glutamic acid-d₅ is the deuterium labeled D-Glutamic acid. D-glutamic acid, an enantiomer of L- glutamic acid, is widely used in pharmaceuticals and foods.

HY-B0228S

Adenosine-d		99.72%
Adenosine-d is the deuterium labeled Adenosine. Adenosine (Adenine riboside), a ubiquitous endogenous autacoid, acts through the enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Adenosine affects almost all aspects of cellular physiology, including neuronal activity, vascular function, platelet aggregation, and blood cell regulation.

HY-128754S1

Monoolein-d₇		≥99.0%
Monoolein-d₇ is deuterium labeled Monoolein. Monoolein is an endogenous metabolite.

HY-B2227BS

Lactate-d₄ sodium (60% in water)		99.04%
Lactate-d₄ sodium (60% in water) is the deuterium labeled Lactate sodium (60% in water). Lactate sodium (60% in water) is the product of glycogenolysis and glycolysis. Lactate sodium (60% in water) functions in a variety of biochemical processes.

HY-12678S1

Entrectinib-d₈		99.82%
Entrectinib-d8 (NMS-E628-d8; RXDX-101-d8) is a deuterated version of Entrectinib (HY-12678). Entrectinib (NMS-E628) is an orally available, blood-brain barrier permeable, central nervous system active TrkA/B/C, ROS1 and ALK inhibitor with IC₅₀ values of 1, 3, 5, 12 and 12, respectively. 7 nM. Entrectinib induces apoptosis and cycle arrest in cancer cells, has anti-tumor activity, and also alleviates bleomycin-induced pulmonary fibrosis in mice.

HY-W244382

Alanine-2,3,3,3-d4		99.81%
Alanine-2,3,3,3-d4 is the deuterium labeled Alanine-2,3,3,3[1].

HY-144243S

Vitamin B5-d₄ calcium		99.51%
Vitamin B5-d₄ (calcium) is the deuterium labeled Vitamin B5 calcium.

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