2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Glucose-6-Phosphate Isomerase (GPI)
  5. Glucose-6-Phosphate Isomerase (GPI) Inhibitor

Glucose-6-Phosphate Isomerase (GPI) Inhibitor

Glucose-6-Phosphate Isomerase (GPI) Inhibitors (2):

Cat. No. Product Name Effect Purity
  • HY-124890
    Thr101
    		Inhibitor 99.36%
    Thr101 is an inhibitor (IC50=2.9 μM) of phosphomannose isomerase (PMI).PMI can compete with phosphomannose mutase 2 (PMM2) for the binding site of Man-6-P and convert mannose-6-phosphate (Man-6-P) into fructose-6-phosphate (Fru-6-P) .Thr101 only specifically inhibits PMI and not PMM2. Thr101 can be used for research of congenital disorder of glycosylation type Ia (CDG-Ia).
  • HY-N6841
    Rhodiolin
    		Inhibitor
    Rhodiolin, a flavonoid, is an orally active glucose 6-phosphate isomerase (GPI) inhibitor. Rhodiolin inhibits papillary thyroid cancer (PTC) by targeting glycolysis enzyme glucose 6-phosphate isomerase GPI and suppressing PI3K/AKT/mTOR phosphorylation and induce apoptosis. Rhodiolin as a NS2B-NS3 protease inhibitor can disrupt dengue viral replication. Rhodiolin is also a potential candidate for developing anticancer strategies inhibiting CK1ε kinase. Rhodiolin can be used for the study of anti-tumor and anti-viral .