1. Signaling Pathways
  2. GPCR/G Protein
  3. G2A (GPR132)
  4. G2A (GPR132) Antagonist

G2A (GPR132) Antagonist

G2A (GPR132) Antagonists (3):

Cat. No. Product Name Effect Purity
  • HY-157189
    GPR132 antagonist 1
    Antagonist 99.72%
    GPR132 antagonist 1 (GPR132-B-160, Compound 25) is a GPR132 antagonist with an EC50 value of 0.075 μM. GPR132 antagonist 1 has promote insulin secretion activity with an EC50 value of 0.7 μM.
  • HY-171854
    SB-583355
    Antagonist
    SB-583355 (Compound 56) is a potent G2A antagonist. SB-583355 can be prepared by a Suzuki reaction between 4-methoxyphenyl boronic acid and 3-bromo-4-hydroxybenzoic acid following the conditions followed by an amide coupling reaction. SB-583355 blocks the activation of G2A mediated either by 9-HOPE or T-10148 in human G2A expressing CHO-K1 cells. SB-583355 can be studied in research for inflammation, myeloid leukemia, and neuropathic pain.
  • HY-157189A
    GPR132 antagonist 1 (dihydrocholide)
    Antagonist
    GPR132 antagonist 1 dihydrocholide (GPR132-B-160, Compound 25) is a GPR132 antagonist with an EC50 value of 0.075 μM. GPR132 antagonist 1 dihydrocholide has promote insulin secretion activity with an EC50 value of 0.7 μM.