2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Dihydrofolate reductase (DHFR)
  5. Dihydrofolate reductase (DHFR) Degrader

Dihydrofolate reductase (DHFR) Degrader

Dihydrofolate reductase (DHFR) Degrader (1):

Cat. No. Product Name Effect Purity
  • HY-178728
    BION106
    		Degrader
    BION106 is a dihydrofolate reductasethymidylate synthase (DHFR-TS) PROTAC degrader. BION106 exhibits extremely strong anti-malarial activity with a Ki and toxicity of 2.68 nM and 0.2 μM against Plasmodium falciparum, and > 100 μM and 44.2 μM in mammalian cells. BION106 can be used for the study of antimalarial parasites (Pink: DHFR-TS ligand (HY-15676); Blue: Idasanutlin ligand (HY-153007); Black: Linker (HY-W021401)).