2. Signaling Pathways
  3. Cytoskeleton
  4. Cadherin
  5. Cadherin Modulator

Cadherin Modulator

Cadherin Modulators (2):

Cat. No. Product Name Effect Purity
  • HY-160623
    INS018 055
    		Modulator 99.96%
    INS018 055 (compound 112) is the orally active TNIK and MAP4K4 inhibitor with IC50 values of 12-120, 12-120 nM, respectively.
  • HY-172551
    anti-TNBC agent-9
    		Modulator
    anti-TNBC agent-9 (Compound 3as) is an anti-cancer agent for triple-negative breast cancer (TNBC). anti-TNBC agent-9 exhibits significant inhibitory activity against MDA-MB-453 cells with an IC50 value of 8.5 μM. anti-TNBC agent-9 inhibits tumor cell migration by upregulating E-cadherin and downregulating N-cadherin, matrix metalloproteinase 2 (MMP2), and MMP9. anti-TNBC agent-9 induces apoptosis by increasing the expression of the pro-apoptotic protein BAX and decreasing the expression of the anti-apoptotic protein BCL-2, thereby inhibiting tumor cell proliferation.