2. Signaling Pathways
  3. Anti-infection
  4. Beta-lactamase

Beta-lactamase

β-lactamase

Beta-lactamase (β-lactamase) is associated with multiple drug resistance in bacteria. It is able to hydrolyze or degrade the β-lactam ring, which is the core structure and active region of many antibiotic molecules such as penicillin, cephalosporins and kanamycin. Bacteria produce Lactamase in response to beta-lactam antibiotics. Using Lactamase inhibitors inhibits the activity of Lactamase so that it cannot destroy the beta-lactam ring of the antibiotic. Lactamase inhibitors are often used with beta-lactam antibiotics to enhance their effectiveness.

Beta-lactamase Isoform Specific Products:

Beta-lactamase Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-B1354
    Cefpiramide
    		Inhibitor 99.27%
    Cefpiramide (SM-1652) free acid is a semisynthetic cephalosporin with broad-spectrum antibacterial activity. Cefpiramide free acid shows strong antibacterial effect on both gram-positive bacteria and gram-negative bacteria. Cefpiramide free acid is moderately susceptible to β-lactamase.
    Cefpiramide
  • HY-136306
    Metallo β-lactamase ligand 1
    		Inhibitor 99.60%
    Metallo-beta-lactamase ligand 1 is a class B β-lactamase inhibitor with antibacterial activity extracted from patent WO2019221122A1, compound A.
    Metallo β-lactamase ligand 1
  • HY-119945A
    Brobactam sodium
    		Inhibitor 99.64%
    Brobactam sodium is a potent synthetic wide spectrum β-lactamase inhibitor. Brobactam sodium has antibacterial activity.
    Brobactam sodium
  • HY-B0593AR
    Ceftazidime pentahydrate (Standard)
    		Inhibitor
    Ceftazidime (pentahydrate) (Standard) is the analytical standard of Ceftazidime (pentahydrate). This product is intended for research and analytical applications. Ceftazidime (GR20263) pentahydrate , an antibiotic, has a broad spectrum activity against Gram-positive and Gram-negative aerobic bacteria. Ceftazidime pentahydrate is also active against Enterobacteriaceae (including β-lactamase-positive strains) and is resistant to hydrolysis by most β-lactamases.
    Ceftazidime pentahydrate (Standard)
  • HY-B0593R
    Ceftazidime (Standard)
    		Inhibitor
    Ceftazidime (Standard) is the analytical standard of Ceftazidime. This product is intended for research and analytical applications. Ceftazidime (GR20263), an antibiotic, has a broad spectrum activity against Gram-positive and Gram-negative aerobic bacteria. Ceftazidime is also active against Enterobacteriaceae (including β-lactamase-positive strains) and is resistant to hydrolysis by most β-lactamases.
    Ceftazidime (Standard)
  • HY-16980S
    Eravacycline-d4 dihydrochloride
    		Inhibitor 99.98%
    Eravacycline-d4 (TP-434-d4) dihydrochloride is deuterium labeled Eravacycline. Eravacycline is a potent and broad-spectrum antibacterial agent.
    Eravacycline-d<sub>4</sub> dihydrochloride
  • HY-16980
    Eravacycline
    		Inhibitor
    Eravacycline is a potent and broad-spectrum antibacterial agent.
    Eravacycline
  • HY-N2359
    Chelerythrine
    		Inhibitor
    Chelerythrine is a natural alkaloid, acts as a potent and selective Ca2+/phospholopid-dependent PKC antagonist, with an IC50 of 0.7 μM. Chelerythrine has antitumor, antidiabetic and anti-inflammatory activity. Chelerythrine inhibits the BclXL-Bak BH3 peptide binding with IC50 of 1.5 μM and displaces Bax from BclXL. Chelerythrine triggers apoptosis and autophagy.
    Chelerythrine
  • HY-139745A
    FPI-1523
    		Inhibitor
    FPI-1523, a derivative of Avibactam, is a potent β-lactamase inhibitor, with Kds of 4 nM and 34 nM for CTX-M-15 and OXA-48, respectively. FPI-1523 also inhibits PBP2, with an IC50 of 3.2 μM. FPI-1523 exhibits considerable antimicrobial activity.
    FPI-1523
  • HY-108062
    BLI-489
    		Inhibitor
    BLI-489 is a beta-lactamase inhibitor. BLI-489 combined with Piperacillin (HY-B1923) inhibits infection caused by class A (including ultra-broad spectrum β-lactamase), Class C (AmpC) and Class D β-lactamase expressing pathogens.
    BLI-489
  • HY-121694
    CENTA
    		≥99.0%
    CENTA is a colorimetric cephalosporin substrate for β-lactamases. Upon hydrolysis by β-lacatamases, CENTA turns from light yellow to chrome yellow, which can be quantified by colorimetric detection at 405 nm as a measure of β-lactamase activity.
    CENTA
  • HY-12826
    IMB-XH1
    		Inhibitor ≥98.0%
    IMB-XH1 is an inhibitor of myeloid cell factor 1 (Mcl-1). IMB-XH1 is a non-competitive Delhi metallo-β-lactamase (NDM-1) inhibitor. The IC50s of IMB-XH1 against metallo-β-lactamases NDM-1, IMP-4, ImiS and L1 are 0.4637 μM, 3.980 μM, 0.2287 μM and 1.158 μM, respectively.
    IMB-XH1
  • HY-N6736
    K-252c
    		Inhibitor ≥99.0%
    K-252c, a staurosporine analog isolated from Nocardiopsis sp., is a cell-permeable PKC inhibitor, with an IC50 of 2.45 µM. K-252c induces apoptosis in human chronic myelogenous leukemia cancer cells. K-252c also inhibits β-lactamase, chymotrypsin, and malate dehydrogenase.
    K-252c
  • HY-19773
    β-Lactamase-IN-1
    		Inhibitor 99.87%
    β-Lactamase-IN-1 is an inhibitor of β-Lactamase extracted from patent WO2016027249A1, page 77. β-Lactamase-IN-1 can be used to prepare of tricyclic nitrogen containing compound. β-Lactamase-IN-1 can be used for the research of neisseria gonorrhea infection.
    β-Lactamase-IN-1
  • HY-B0698
    Ceftibuten
    		Inhibitor
    Ceftibuten (Sch39720), an antibiotic, is an orally active cephalosporin, possesses potent activity in vitro against a wide range of gram-negative and certain gram-positive pathogens.
    Ceftibuten
  • HY-B1463R
    Penicillin G sodium salt (Standard)
    		Inhibitor
    Penicillin G sodium salt (Standard) is the analytical standard of Penicillin G sodium salt. This product is intended for research and analytical applications. Penicillin G sodium salt is a typical β-lactam antibiotic.
    Penicillin G sodium salt (Standard)
  • HY-B1117R
    Cefoxitin sodium (Standard)
    Cefoxitin sodium (Standard) is the analytical standard of Cefoxitin sodium. This product is intended for research and analytical applications. Cefoxitin sodium is a cephalosporin-class antibiotic. Cefoxitin sodium is highly stable against β-Lactamase (HY-P2998). Cefoxitin sodium has a broad spectrum of antibacterial activity, including Gram-negative and Gram-positive bacteria.
    Cefoxitin sodium (Standard)
  • HY-129629
    Thiomandelic acid
    		Inhibitor
    Thiomandelic acid is a broad spectrum inhibitor of Zinc -lactamases.
    Thiomandelic acid
  • HY-14879C
    Avibactam sodium dihydrate
    		Inhibitor
    Avibactam sodium (NXL-104) dihydrate is a covalent and reversible non-β-lactam β-lactamase inhibitor which inhibits β-lactamase TEM-1 and CTX-M-15 with IC50s of 8 nM and 5 nM, respectively.
    Avibactam sodium dihydrate
  • HY-136071
    QPX7728 methoxy acetoxy methy ester
    		Inhibitor
    QPX7728 methoxy acetoxy methy ester is a boronic acid β-lactamase inhibitor, exacted from WO2018005662A1, compound 43.
    QPX7728 methoxy acetoxy methy ester
Beta-lactamase Isoform Comparison

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