2. Signaling Pathways
  3. Autophagy
  4. Atg8/LC3
  5. Atg8/LC3 Inducer

Atg8/LC3 Inducer

Atg8/LC3 Inducers (2):

Cat. No. Product Name Effect Purity
  • HY-176749
    HUP-46
    		Inducer
    HUP-46 is a BBB-penatrable modulator of αSyn dimerization and autophagy. HUP-46 reduces the ratio of pPP2A/PP2A, increases the autophagy marker LC3BII levels, and decreases αSyn dimerization. HUP-46 can be used for research of neurodegenerative diseases.
  • HY-170992
    Autophagy agonist-1
    		Inducer
    Autophagy agonist-1 (compound 22) is an Autophagy agonist. Autophagy agonist-1 exhibits significant anticancer activity against HepG2 cells and normal cells with IC50s of 8.8 μM and > 50 μM. Autophagy agonist-1 induces G1/S phase cell cycle arrest and inhibits CDK4 and CyclinD1 expression while upregulating P21. Autophagy agonist-1 promotes the accumulation of autophagosomes and the proteins LC3 and PINK1, enhancing autophagy and mitophagy in HepG2 cells.