2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Amylases

Amylases

Amylases are crucial enzymes which hydrolyze internal glycosidic linkages in starch and produce as primary products dextrins and oligosaccharides. Amylases are classified into α-amylase, β-amylase, and glucoamylase based on their three-dimensional structures, reaction mechanisms, and amino acid sequences. Amylases have innumerable applications in clinical, medical, and analytical chemistries as well as in food, detergent, textile, brewing, and distilling industries.

Amylases Related Products (77):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-161944
    α-Amylase-IN-8
    		Inhibitor
    α-Amylase-IN-8 (compound 44) ​​is an α-amylase inhibitor (IC50=58.1 μM). α-Amylase-IN-8 can be used in the research of type 2 diabetes.
    α-Amylase-IN-8
  • HY-149313
    α‑Amylase-IN-1
    		Inhibitor 98.33%
    α Amylase-IN-1 (Compound 11) is an α-Amylase inhibitor with an IC50 value of 0.5509 μM. α Amylase-IN-1 has antioxidant activity with an IC50 value of 53.49 μM for scavenging DPPH free radicals. IC50 can be used in the study of diabetes and oxidative stress-related diseases.
    α‑Amylase-IN-1
  • HY-N12263
    3,5,6,7,8,4'-Hexamethoxyflavone
    		Inhibitor
    3,5,6,7,8,4'-Hexamethoxyflavone is a inhibitor of α-Amylase with the inhibitory activity of 28.3% at 500 μM.
    3,5,6,7,8,4'-Hexamethoxyflavone
  • HY-B2193C
    α-Amylase, Porcine Pancreatic
    α-Amylase, Porcine Pancreatic (1,4-alpha-D-Glucan-glucanohydrolase, amy2, PPA, PA) is a biological material or organic compound that can be used in life science research.
    α-Amylase, Porcine Pancreatic
  • HY-149973
    α-Amylase-IN-4
    α-Amylase-IN-4 (Compd 10y) show maximum inhibition of amylase activity with IC50 value 17.83 ± 0.14 μg/mL.
    α-Amylase-IN-4
  • HY-161461
    E234G HYPE-IN-1
    		Inhibitor
    E234G HYPE-IN-1 (Compound I2.10) is an inhibitor of AMPylation directed by the Huntingtin-interacting protein E (HYPE), possessing low micromolar bioactivity, low cytotoxicity, and blood-brain barrier permeability. E234G HYPE-IN-1 can inhibit the AMPylation of B-cell immunoglobulin-binding protein (BiP), the primary substrate of HYPE. E234G HYPE-IN-1 is suitable for development as a HYPE-specific therapeutic agent for clinical conditions such as neurodegenerative diseases and diabetes.
    E234G HYPE-IN-1
  • HY-159491
    DPP-4-IN-11
    		Inhibitor
    DPP-4-IN-11 (compound 10) is an orally active DPP-4 inhibitor (IC50=2.75 μM) with anti-type 2 diabetes activity. DPP-4-IN-11 exerts its glucose-lowering effect by inhibiting the activities of α-glucosidase (IC50=3.02 μM) and α-amylase (IC50=3.3 μM).
    DPP-4-IN-11
  • HY-162634
    α-Amylase/α-Glucosidase-IN-15
    		Inhibitor
    α-Amylase/α-Glucosidase-IN-15 (compound 6C) is an oral bioactive inhibitor of α-Glucosidase and α-amylase, with the IC50s of 21 μM and 61 μM, respectively.
    α-Amylase/α-Glucosidase-IN-15
  • HY-146752
    α-Amylase-IN-1
    α-Amylase-IN-1 is a potent α-amylase inhibitor with an IC50 of 4.46 μM.
    α-Amylase-IN-1
  • HY-168598
    α-Amylase-IN-9
    		Inhibitor
    α-Amylase-IN-9 (Compound 1i) is an inhibitor of α-Amylase with an IC50 value of 14.64 μM, which can be used in diabetes research.
    α-Amylase-IN-9
  • HY-168074
    4″-C18 EGCG
    		Inhibitor
    4″-C18 EGCG is a potent inhibitor of α-amylase and α-glucosidase with IC50 values of 3.74 and 0.81 μM, respectively. 4″-C18 EGCG inhibits carbohydrate hydrolases, reduces oxidative stress and inflammation, and exhibits antidiabetic activity. 4″-C18 EGCG also downregulates proinflammatory cytokines and is cytotoxic to primary human peripheral blood mononuclear cells (PBMCs), non-cancer cell lines 3T3-L1, and HEK 293 at 50 μM.
    4″-C18 EGCG
  • HY-161469
    α-Amylase/α-Glucosidase-IN-13
    		Inhibitor
    α-Amylase/α-Glucosidase-IN-13 (Compound 5d) is a dual inhibitor of α-Amylase/α-Glucosidase that can be used for diabetes research.
    α-Amylase/α-Glucosidase-IN-13
  • HY-162390
    α-Amylase/α-Glucosidase-IN-11
    		Inhibitor
    α-Amylase/α-Glucosidase-IN-11 (Compound 5d) is a isoxazolidine-isatin hybrid with significant antidiabetic activity. α-Amylase/α-Glucosidase-IN-11 competitively inhibits α-amylase (IC50 = 30.39 μM) and α-glucosidase (IC50 = 65.1 μM), two key digestive enzymes. α-Amylase/α-Glucosidase-IN-11 does not cross the blood-brain barrier.
    α-Amylase/α-Glucosidase-IN-11
  • HY-P1543
    Exendin-3
    		Agonist 98.31%
    Exendin-3 is a biologically active peptides isolated from venoms of the Gila monster lizards, Heloderma horridurn.
    Exendin-3
  • HY-155241
    α-Amylase/α-Glucosidase-IN-4
    		Inhibitor
    α-Amylase/α-Glucosidase-IN-4 (compound 5) is a dual inhibitor of α-glucosidase (Glucosidase) and α-amylase (Amylases) with IC50s of 0.15 μM and 1.10 μM, respectively. α-Amylase/α-Glucosidase-IN-4 has potential antidiabetic activity.
    α-Amylase/α-Glucosidase-IN-4
  • HY-143269
    HPA-IN-2
    		Inhibitor
    HPA-IN-2 (Compound 2a-1) is a potent and selective human pancreatic α-amylase (HPA) inhibitor with IC50 values of 8.2 μM and 450.7 μM against HPA and α-glucosidase, respectively.
    HPA-IN-2
  • HY-N7729
    Sekikaic acid
    		Inhibitor
    Sekikaic acid is an α-glucosidase (Glucosidase) and α-amylase (Amylases) inhibitor with hypolipidemic, antioxidant and antidiabetic activities. Sekikaic acid significantly reduces LDL, total cholesterol, and total glyceride levels and causes pancreatic beta cell regeneration.
    Sekikaic acid
  • HY-168495
    α-Amylase-IN-12
    		Inhibitor
    α-Amylase-IN-12 (Compound 5e) is an α-amylase inhibitor (IC50: 0.15 mM) with a mixed inhibition. α-Amylase-IN-12 has an IC50 of 9.40 mM against α-glucosidase. α-Amylase-IN-12 promotes glucose uptake in yeast cells and exhibits significant antiglycation activity at high concentrations. α-Amylase-IN-12 can be used for the research of diabetes.
    α-Amylase-IN-12
  • HY-175605
    α-Amylase/α-Glucosidase-IN-21
    		Inhibitor
    α-Amylase/α-Glucosidase-IN-21 (Compound 4) is a dual-functional inhibitor of α-Glucosidase and α-Amylase with IC50s of 0.27 and  0.19 µg/mL for α-Glucosidase and α-Amylase, respectively. α-Amylase/α-Glucosidase-IN-21 has an antidiabetic activity.α-Amylase/α-Glucosidase-IN-21 can be used for diabetes mellitus research.
    α-Amylase/α-Glucosidase-IN-21
  • HY-N11728
    2,7"-Phloroglucinol-6,6'-bieckol
    		Inhibitor
    2,7"-Phloroglucinol-6,6'-bieckol is an orally active dual α-amylase/α-glucosidase inhibitor with IC50 values of 6.94 μM and 23.35 μM respectively. 2,7"-Phloroglucinol-6, 6'-bieckol alleviates postprandial hyperglycemia in diabetic mice. 2,7"-Phloroglucinol-6,6'-bieckol can be used in diabetes research.
    2,7