Amino Acid Derivatives

Amino Acid Derivatives are bioactive molecules formed through chemical modifications or metabolic transformations of amino acids. They are widely present in living organisms and play crucial roles in physiological, psychological, and athletic performance.
The functions of these derivatives primarily include enhancing energy supply, regulating neurotransmitters, promoting fat metabolism, and reducing muscle damage. For example, creatine can increase muscle strength, enhance ATP resynthesis, and improve short-duration high-intensity exercise performance; tyrosine, as a precursor of dopamine and norepinephrine, helps enhance cognitive function and improve mood, particularly in sleep deprivation conditions, exhibiting anti-fatigue effects; carnitine facilitates fatty acid oxidation in the heart and skeletal muscles, improving endurance performance; HMB (β-hydroxy-β-methylbutyrate) reduces muscle breakdown and promotes muscle mass gain; while taurine exhibits antioxidant and antihypertensive properties and reduces oxidative stress induced by exercise.
Metabolic abnormalities or improper supplementation of amino acid derivatives may be associated with various diseases. For instance, tyrosine metabolism disorders can disrupt neurotransmitter balance, potentially leading to depression or stress-related disorders; elevated ADMA (asymmetric dimethylarginine) levels can inhibit nitric oxide synthesis, increasing the risk of cardiovascular diseases; carnitine deficiency is linked to certain genetic muscle disorders, impairing fat metabolism and energy production. Additionally, HMB may help slow muscle loss under specific conditions, while taurine intake is associated with improved cardiovascular health. Although some of the effects of these derivatives remain debated, they hold significant potential applications in sports nutrition, neurological regulation, and metabolic health.

References:

[1]. Luckose F, et al. Effects of amino acid derivatives on physical, mental, and physiological activities. Crit Rev Food Sci Nutr. 2015;55(13):1793-807. [Content Brief]

Amino Acid Derivatives Related Products (1603):

By Effects:	Inhibitor (1) Chemical (1)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-W010895

Fmoc-1-Nal-OH		99.89%
Fmoc-1-Nal-OH is an alanine derivative.

HY-W041989

Fmoc-Oic-OH		99.86%
Fmoc-Oic-OH is an amino acid derivative with an Fmoc protecting group, which can be used to synthesize bioactive peptide mimetics, such as [desArg¹⁰]HOE 140, which has bradykinin B1 antagonist activity.

HY-W010962

Fmoc-Dap(Alloc)-OH		99.59%
Fmoc-Dap(Alloc)-OH is an alanine derivative.

HY-128676

N-ε-propargyloxycarbonyl-L-lysine hydrochloride		99.80%
N-ε-propargyloxycarbonyl-L-lysine (H-L-Lys(Poc)-OH) hydrochloride is a lysine-based unnatural amino acid (UAA). N-ε-propargyloxycarbonyl-L-lysine is widely used for bio-conjugation of fluorescent probes in diverse organisms from E. coli to mammalian cells even in animals. N-ε-propargyloxycarbonyl-L-lysine (hydrochloride) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-W010959

Fmoc-Asp-OtBu		99.91%
Fmoc-Asp-OtBu is an aspartic acid derivative.

HY-W048918

N-(((9H-Fluoren-9-yl)methoxy)carbonyl)-S-trityl-L-homocysteine		99.78%
N-(((9H-Fluoren-9-yl)methoxy)carbonyl)-S-trityl-L-homocysteine is a cysteine derivative.

HY-101404A

L-Homocysteine thiolactone hydrochloride		99.99%
L-Homocysteine thiolactone hydrochloride is an intramolecular thioester of Homocysteine. Homocysteine thiolactone hydrochloride prevents translational incorporation of homocysteine into proteins. L-Homocysteine thiolactone hydrochloride can induce elevated HHcy (hyperhomocysteinemia) in mice.

HY-W041984

Fmoc-Cpg-OH		99.98%
Fmoc-Cpg-OH is a Glycine (HY-Y0966) derivative.

HY-W014919

H-Phe(2-Cl)-OH		99.92%
H-Phe(2-Cl)-OH is a phenylalanine derivative.

HY-W008064

Fmoc-Cit-OH		99.32%
Fmoc-Cit-OH (Fmoc-L-Citrulline) is an amino acid derivative with an Fmoc protecting group, which can be used to synthesize a degradable ADC linker composed of a valine-citrulline (Val-Cit) motif.

HY-W007056

Fmoc-N-me-Trp(Boc)-OH		99.70%
Fmoc-N-me-Trp(Boc)-OH is an amino acid derivative with an Fmoc protecting group, which can be used to synthesize peptide antibiotics with antibacterial activity against Pseudomonas aeruginosa.

HY-W008426

Fmoc-D-Tyr(tBu)-OH		99.91%
Fmoc-D-Tyr(tBu)-OH is a tyrosine derivative.

HY-W097054

Fmoc-L-cysteic acid
Fmoc-L-cysteic acid is an amino acid derivative with an Fmoc protecting group, which can be used to synthesize triarylsulfonium compounds for radiolabeling of peptides.

HY-W040804

2-Amino-3-(2-oxo-1,2-dihydroquinolin-4-yl)propanoic acid hydrochloride		99.51%
2-Amino-3-(2-oxo-1,2-dihydroquinolin-4-yl)propanoic acid hydrochloride is an alanine derivative.

HY-W008075

Fmoc-Asp(OAll)-OH		99.89%
Fmoc-Asp(OAll)-OH is an aspartic acid derivative.

HY-W048911

(((9H-Fluoren-9-yl)methoxy)carbonyl)-L-histidine		99.73%
(((9H-Fluoren-9-yl)methoxy)carbonyl)-L-histidine is a histidine derivative.

HY-114348

N,N'-Diacetyl-L-cystine		99.06%
N,N'-diacetyl-L-cystine (DiNAC) is the disulphide dimer of N-acetylcysteine with immunomodulating properties. N,N'-diacetyl-L-cystine is a potent, orally active modulator of contact sensitivity/delayed type hypersensitivity reactions in rodents. N,N'-diacetyl-L-cystine also has antiatherosclerotic effects in Watanabe-heritable hyperlipidemic rabbit (WHHL) rabbits.

HY-W008113

Boc-L-Homoserine
Boc-L-Homoserine is a serine derivative.

HY-W013726

Fmoc-Phe(4-Br)-OH		99.83%
Fmoc-Phe(4-Br)-OH is a widely used amino acid derivative. Fmoc-Phe(4-Br)-OH can be used in the synthesis of compounds and for the study of protein-protein interactions and the development of biomaterials. Fmoc-Phe(4-Br)-OH can be used in peptide synthesis to incorporate phenylalanine bromide into the peptide chain.

HY-79877

Boc-Ser(Tos)-OMe		≥99.0%
Boc-Ser(Tos)-OMe is a serine derivative.

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