Amino Acid Derivatives

Amino Acid Derivatives are bioactive molecules formed through chemical modifications or metabolic transformations of amino acids. They are widely present in living organisms and play crucial roles in physiological, psychological, and athletic performance.
The functions of these derivatives primarily include enhancing energy supply, regulating neurotransmitters, promoting fat metabolism, and reducing muscle damage. For example, creatine can increase muscle strength, enhance ATP resynthesis, and improve short-duration high-intensity exercise performance; tyrosine, as a precursor of dopamine and norepinephrine, helps enhance cognitive function and improve mood, particularly in sleep deprivation conditions, exhibiting anti-fatigue effects; carnitine facilitates fatty acid oxidation in the heart and skeletal muscles, improving endurance performance; HMB (β-hydroxy-β-methylbutyrate) reduces muscle breakdown and promotes muscle mass gain; while taurine exhibits antioxidant and antihypertensive properties and reduces oxidative stress induced by exercise.
Metabolic abnormalities or improper supplementation of amino acid derivatives may be associated with various diseases. For instance, tyrosine metabolism disorders can disrupt neurotransmitter balance, potentially leading to depression or stress-related disorders; elevated ADMA (asymmetric dimethylarginine) levels can inhibit nitric oxide synthesis, increasing the risk of cardiovascular diseases; carnitine deficiency is linked to certain genetic muscle disorders, impairing fat metabolism and energy production. Additionally, HMB may help slow muscle loss under specific conditions, while taurine intake is associated with improved cardiovascular health. Although some of the effects of these derivatives remain debated, they hold significant potential applications in sports nutrition, neurological regulation, and metabolic health.

References:

[1]. Luckose F, et al. Effects of amino acid derivatives on physical, mental, and physiological activities. Crit Rev Food Sci Nutr. 2015;55(13):1793-807. [Content Brief]

Amino Acid Derivatives Related Products (1606):

By Effects:	Inhibitor (1) Chemical (1)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-P2405

Fmoc-Gly-Ser(psi(Me,Me)pro)-OH		99.78%
Fmoc-Gly-Ser(psi(Me,Me)pro)-OH is a dipeptide.

HY-101877

Statine		99.83%
Statine is an unusual amino acid that occurs twice in the sequence of pepstatin, a protease inhibitor that is active against pepsin and other acid proteases.

HY-W011001

(R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-cyclohexylpropanoic acid		99.83%
(R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-cyclohexylpropanoic acid is an alanine derivative.

HY-103664

Fmoc-1,6-diaminohexane		99.29%
Fmoc-1,6-diaminohexane is an analog of Osw-1 which has the potential for Alzheimer's disease and cancer treatment from patent US 20140135279 A1.

HY-W010793

Fmoc-Bpa-OH		99.77%
Fmoc-Bpa-OH is a phenylalanine derivative.

HY-117195

Lauroyl lysine		≥98.0%
Lauroyl lysine (N6-Lauroyl-L-lysine) is a compound that can be synthesized by recombinant enzymes. After the synthase is cloned and expressed, it can be used to synthesize lauroyl lysine from specific raw materials with high yield.

HY-W091734

Methyl 4-iodo-L-phenylalaninate hydrochloride
Methyl 4-iodo-L-phenylalaninate hydrochloride is a Phenylalaninate derivative. Methyl 4-iodo-L-phenylalaninate hydrochloride can be used for the preparation of factor XI modulators used in the research of thrombotic and thromboembolic. Methyl 4-iodo-L-phenylalaninate hydrochloride can also be used for the synthesis of compounds for the research of amyloid-related diseases, such as Alzheimer’s disease.

HY-W013734

N,N'-Di-BOC-L-cystine
N,N'-Di-BOC-L-cystine is a cysteine derivative.

HY-N2378

(2R,3S)-3-Phenylisoserine hydrochloride
(2R,3S)-3-Phenylisoserine hydrochloride is a serine derivative.

HY-79415

4-Methyl-L-leucine
4-Methyl-L-leucine is a Glycine (HY-Y0966) derivative.

HY-W141922

N-(Methylsulfonyl)glycine
N-(Methylsulfonyl)glycine is a Glycine (HY-Y0966) derivative.

HY-I0393

3-(2-Thienyl)-L-alanine		99.66%
3-(2-Thienyl)-L-alanine is an alanine derivative.

HY-41912

Boc-Nle-OH
Boc-Nle-OH is a leucine derivative.

HY-W141774

S-(2-Carboxyethyl)-L-cysteine		98.64%
S-(2-Carboxyethyl)-L-cysteine (S-Carboxyethylcysteine) is a non-protein (modified) sulfur amino acid. S-(2-Carboxyethyl)-L-cysteine is present in Acacia seed. S-(2-Carboxyethyl)-L-cysteine can affect the seed’s protein use in rats. S-(2-Carboxyethyl)-L-cysteine suppresses the methionine-induced growth rate, and has a negative effect on the plasma amino acid levels in rats.

HY-W006937

Boc-D-(4-fmoc)-aminophenylalanine		≥98.0%
Boc-D-(4-fmoc)-aminophenylalanine (Boc-p-amino-D-Phe(Fmoc)-OH) is an amino acid derivative with an Fmoc protecting group, which can be used to synthesize peptides with gonadotropin-releasing hormone antagonist activity.

HY-34540

(αS)-α-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-2-pyridinepropanoic acid		99.94%
(αS)-α-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-2-pyridinepropanoic acid is an alanine derivative.

HY-W013153

Fmoc-D-Tic-OH		99.93%
Fmoc-D-Tic-OH is an amino acid derivative with an Fmoc protecting group, which can be used to synthesize bioactive peptide mimetics, such as [desArg¹⁰]HOE 140, which has bradykinin B1 antagonist activity.

HY-107848

DL-O-Tyrosine		98.23%
DL-O-Tyrosine is a tyrosine derivative.

HY-122526

Thialysine hydrochloride		98.0%
Thialysine (hydrochloride) is a cysteine derivative.

HY-I0517

H-Ala-OEt.HCl
H-Ala-OEt.HCl is an alanine derivative.

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