Amino Acid Derivatives

Amino Acid Derivatives are bioactive molecules formed through chemical modifications or metabolic transformations of amino acids. They are widely present in living organisms and play crucial roles in physiological, psychological, and athletic performance.
The functions of these derivatives primarily include enhancing energy supply, regulating neurotransmitters, promoting fat metabolism, and reducing muscle damage. For example, creatine can increase muscle strength, enhance ATP resynthesis, and improve short-duration high-intensity exercise performance; tyrosine, as a precursor of dopamine and norepinephrine, helps enhance cognitive function and improve mood, particularly in sleep deprivation conditions, exhibiting anti-fatigue effects; carnitine facilitates fatty acid oxidation in the heart and skeletal muscles, improving endurance performance; HMB (β-hydroxy-β-methylbutyrate) reduces muscle breakdown and promotes muscle mass gain; while taurine exhibits antioxidant and antihypertensive properties and reduces oxidative stress induced by exercise.
Metabolic abnormalities or improper supplementation of amino acid derivatives may be associated with various diseases. For instance, tyrosine metabolism disorders can disrupt neurotransmitter balance, potentially leading to depression or stress-related disorders; elevated ADMA (asymmetric dimethylarginine) levels can inhibit nitric oxide synthesis, increasing the risk of cardiovascular diseases; carnitine deficiency is linked to certain genetic muscle disorders, impairing fat metabolism and energy production. Additionally, HMB may help slow muscle loss under specific conditions, while taurine intake is associated with improved cardiovascular health. Although some of the effects of these derivatives remain debated, they hold significant potential applications in sports nutrition, neurological regulation, and metabolic health.

References:

[1]. Luckose F, et al. Effects of amino acid derivatives on physical, mental, and physiological activities. Crit Rev Food Sci Nutr. 2015;55(13):1793-807. [Content Brief]

Amino Acid Derivatives Related Products (1606):

By Effects:	Inhibitor (1) Chemical (1)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-Y1824

N-9-Fluorenylmethoxycarbonylaspartic acid β-methyl ester		99.86%
N-9-Fluorenylmethoxycarbonylaspartic acid β-methyl ester is an aspartic acid derivative.

HY-W007399

Boc-Asp(OMe)-OH		99.0%
Boc-Asp(OMe)-OH is an aspartic acid derivative.

HY-137002

Fmoc-N-Me-Arg(Pbf)-OH		98.28%
Fmoc-N-Me-Arg(Pbf)-OH is an amino acid derivative containing a guanidinium protecting group on the arginine side chain. Fmoc-N-Me-Arg(Pbf)-OH is used in the synthesis of neurotensin-derived NTS1 ligands for PET imaging.

HY-W001158

N,N-Dimethylglycine hydrochloride		≥98.0%
N,N-Dimethylglycine (Dimethylglycine) hydrochloride, a natural N-methylated glycine, is a nutrient supplement and acts as an NMDAR glycine site partial agonist. N,N-Dimethylglycine hydrochloride is a methyl donor that can improve immunity, act as an antioxidant to prevent oxidative stress, and scavenge excess free radicals. N,N-Dimethylglycine hydrochloride has antidepressant-like and surfactant effects.

HY-W011178

Boc-Phe(4-Br)-OH		99.70%
Boc-Phe(4-Br)-OH is a phenylalanine derivative.

HY-20582

L-Prolinamide		99.93%
L-Prolinamide is a proline derivative.

HY-W005117

H-DL-Gly-OBzl hydrochloride		99.56%
H-DL-Gly-OBzl (hydrochloride) is a Glycine (HY-Y0966) derivative.

HY-N7831

N-Oleoyl alanine
N-Oleoyl alanine (OlAla) is aalanine derivatives.

HY-Y1080

N-Acetyl-R-leucine		≥98.0%
N-Acetyl-R-leucine is an amino-protecting group N-substituted chiral amino acid. N-Acetyl-R-leucine is a PepT1 and MCT1 inhibitor with IC₅₀ of 0.74 and 11 mM, respectively. N-Acetyl-R-leucine can be used for LysoTracker signaling studies.

HY-W013678

H-Glu(OMe)-OH		98.0%
H-Glu(OMe)-OH is a glutamic acid derivative.

HY-W008555

Fmoc-N-Me-Ile-OH		99.88%
Fmoc-N-Me-Ile-OH is a used in peptide synthesis.

HY-W072147

Fmoc-Ser-OMe		99.71%
Fmoc-Ser-OMe (Fmoc-L-Ser-OMe) is a hydroxylated L-amino acid protected with a 9-fluorenylmethyloxycarbonyl (Fmoc) group. Fmoc-Ser-OMe involves in chlorophyll–amino acid conjugates synthesis, and acts as a chromo/fluorophores modified protein and emits visible to near-infrared lights efficiently. Fmoc-Ser-OMe glycosylates and produces small mucin-related Olinked glycopeptides, as an alcohol acceptor.

HY-W141821

Fmoc-Phe(CF2PO3)-OH		≥98.0%
Fmoc-Phe(CF2PO3)-OH is a phenylalanine derivative.

HY-W013123

Fmoc-D-Phe(4-CF3)-OH		99.09%
Fmoc-D-Phe(4-CF3)-OH is Phenylalanine derivative. Fmoc-D-Phe(4-CF3)-OH can be used for the research of peptide inhibitors of protein-protein interactions.

HY-W067091

3-((((9H-Fluoren-9-yl)methoxy)carbonyl)(methyl)amino)propanoic acid
3-((((9H-Fluoren-9-yl)methoxy)carbonyl)(methyl)amino)propanoic acid is an alanine derivative.

HY-W042001

H-DL-Phe(4-Me)-OH		99.74%
H-DL-Phe(4-Me)-OH is a phenylalanine derivative.

HY-W111226

Fmoc-His(3-Me)-OH		≥98.0%
Fmoc-His(3-Me)OH derives Histidine-associating compounds with biological activity. Fmoc-His(3-Me)OH, with Fmoc-citrulline-OH, Fmoc-His(1-Me)-OH together, forms tri-peptides and shows vasodilating effect with EC₅₀s of 2.7-4.7 mM in 1.0 mM Phenylephrine (PE)-contracted aorta rings. Fmoc-His(3-Me)OH (resin) also makes Methyl-His-Gly-Lys (His(3-Me)-Gly-Lys), thus acts as an [Ca²⁺]_i inhibitor. Fmoc-His(3-Me)OH methylates NAHIS02, making it unable to block the Alzheimer's Aβ channel.

HY-W018717

Boc-Gly-Pro-OH		99.9%
Boc-Gly-Pro-OH is a Glycine (HY-Y0966) derivative.

HY-W041991

Fmoc-Ser-Obzl		99.67%
Fmoc-Ser-Obzl is a serine derivative.

HY-W025811

1-(tert-Butyl) 5-methyl L-glutamate hydrochloride		98.0%
1-(tert-Butyl) 5-methyl L-glutamate hydrochloride is a glutamic acid derivative.

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