Amino Acid Derivatives

Amino Acid Derivatives are bioactive molecules formed through chemical modifications or metabolic transformations of amino acids. They are widely present in living organisms and play crucial roles in physiological, psychological, and athletic performance.
The functions of these derivatives primarily include enhancing energy supply, regulating neurotransmitters, promoting fat metabolism, and reducing muscle damage. For example, creatine can increase muscle strength, enhance ATP resynthesis, and improve short-duration high-intensity exercise performance; tyrosine, as a precursor of dopamine and norepinephrine, helps enhance cognitive function and improve mood, particularly in sleep deprivation conditions, exhibiting anti-fatigue effects; carnitine facilitates fatty acid oxidation in the heart and skeletal muscles, improving endurance performance; HMB (β-hydroxy-β-methylbutyrate) reduces muscle breakdown and promotes muscle mass gain; while taurine exhibits antioxidant and antihypertensive properties and reduces oxidative stress induced by exercise.
Metabolic abnormalities or improper supplementation of amino acid derivatives may be associated with various diseases. For instance, tyrosine metabolism disorders can disrupt neurotransmitter balance, potentially leading to depression or stress-related disorders; elevated ADMA (asymmetric dimethylarginine) levels can inhibit nitric oxide synthesis, increasing the risk of cardiovascular diseases; carnitine deficiency is linked to certain genetic muscle disorders, impairing fat metabolism and energy production. Additionally, HMB may help slow muscle loss under specific conditions, while taurine intake is associated with improved cardiovascular health. Although some of the effects of these derivatives remain debated, they hold significant potential applications in sports nutrition, neurological regulation, and metabolic health.

References:

[1]. Luckose F, et al. Effects of amino acid derivatives on physical, mental, and physiological activities. Crit Rev Food Sci Nutr. 2015;55(13):1793-807. [Content Brief]

Amino Acid Derivatives Chemical (1)

Amino Acid Derivatives Related Products (1590):

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-W008016

Fmoc-Tyr(tBu)-OH		99.93%
Fmoc-Tyr(tBu)-OH is a tyrosine derivative.

HY-W008034

Fmoc-Trp(Boc)-OH		99.90%
Fmoc-Trp(Boc)-OH (Fmoc-L-Trp(Boc)-OH) is an amino acid derivative with protective groups. Fmoc-Trp(Boc)-OH can self-assemble into stable and pH-responsive spherical nanoparticles, which can load and release bioactive molecules, with good biocompatibility and high cell uptake rate. Fmoc-Trp(Boc)-OH can be used in research on drug delivery.

HY-W007798

Fmoc-Cys(Trt)-OH		99.98%
Fmoc-Cys(Trt)-OH is a cysteine derivative.

HY-W010964

Fmoc-Hyp(tBu)-OH		99.28%
Fmoc-Hyp(tBu)-OH is a proline derivative.

HY-P4632

H-γ-Glu-Leu-OH		99.67%
H-γ-Glu-Leu-OH (γ-Glu-Leu) is a dipeptide consisting of γ-glutamic acid and leucine, terminated by a hydroxyl group.

HY-W007941

Fmoc-Ser(tBu)-OH		99.98%
Fmoc-Ser(tBu)-OH is a serine derivative.

HY-I1111

Fmoc-L-Val-OH		99.93%
Fmoc-L-Val-OH is a valine derivative.

HY-W011210

Fmoc-Pra-OH		99.93%
Fmoc-Pra-OH is a Glycine (HY-Y0966) derivative. Fmoc-Pra-OH is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-Y1166

N-(9-Fluorenylmethoxycarbonyl)glutamic acid α-tert-butyl ester		99.93%
N-(9-Fluorenylmethoxycarbonyl)glutamic acid α-tert-butyl ester is a glutamic acid derivative.

HY-101552A

L,L-Dityrosine		99.80%
L,L-Dityrosine (o,o'-Dityrosine) is a constituent of acid hydrolysates of a number of biological materials, including the insect cuticular resilin.

HY-19821

Fmoc-Ile-OH		99.96%
Fmoc-Ile-OH is an isoleucine derivative.

HY-W041987

Fmoc-L-Lys(Dde)-OH		99.76%
Fmoc-L-Lys(Dde)-OH is a lysine derivative.

HY-79131

Fmoc-Phe-OH		99.90%
Fmoc-Phe-OH is a phenylalanine derivative.

HY-W008876

Fmoc-Pen(Trt)-OH		99.93%
Fmoc-Pen(Trt)-OH is an amino acid derivative with an Fmoc protecting group that can be used to synthesize the inhibitory cystine knot (ICK) peptide ProTx-II.

HY-W010836

Fmoc-Bip(4,4')-OH		99.76%
Fmoc-Bip(4,4')-OH is an alanine derivative.

HY-W142080

α-Methyl-DL-tryptophan		99.92%
α-Methyl-DL-tryptophan (α-Methyltryptophan), a tryptophan derivative, is a selective SLC6A14 blocker. In estrogen receptor (ER)-positive breast cancer cells, α-Methyl-DL-tryptophan inhibits mTOR and activates autophagy and apoptosis. α-Methyl-DL-tryptophan also has the effect of reducing weight.

HY-W008872

Fmoc-Lys(Mtt)-OH		99.61%
Fmoc-Lys(Mtt)-OH is a lysine derivative.

HY-W010714

Fmoc-D-Gln(Trt)-OH		99.76%
Fmoc-D-Gln(Trt)-OH is a glutamine derivative.

HY-W010862

Fmoc-Lys(Alloc)-OH		99.77%
Fmoc-Lys(Alloc)-OH is a lysine derivative.

HY-Y0511

N,N-Dimethylglycine		≥98.0%
N,N-Dimethylglycine (Dimethylglycine), a natural N-methylated glycine, is a nutrient supplement and acts as an NMDAR glycine site partial agonist. N,N-Dimethylglycine is a methyl donor that can improve immunity, act as an antioxidant to prevent oxidative stress, and scavenge excess free radicals. N,N-Dimethylglycine has antidepressant-like and surfactant effects.

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