Amino Acid Derivatives

Amino Acid Derivatives are bioactive molecules formed through chemical modifications or metabolic transformations of amino acids. They are widely present in living organisms and play crucial roles in physiological, psychological, and athletic performance.
The functions of these derivatives primarily include enhancing energy supply, regulating neurotransmitters, promoting fat metabolism, and reducing muscle damage. For example, creatine can increase muscle strength, enhance ATP resynthesis, and improve short-duration high-intensity exercise performance; tyrosine, as a precursor of dopamine and norepinephrine, helps enhance cognitive function and improve mood, particularly in sleep deprivation conditions, exhibiting anti-fatigue effects; carnitine facilitates fatty acid oxidation in the heart and skeletal muscles, improving endurance performance; HMB (β-hydroxy-β-methylbutyrate) reduces muscle breakdown and promotes muscle mass gain; while taurine exhibits antioxidant and antihypertensive properties and reduces oxidative stress induced by exercise.
Metabolic abnormalities or improper supplementation of amino acid derivatives may be associated with various diseases. For instance, tyrosine metabolism disorders can disrupt neurotransmitter balance, potentially leading to depression or stress-related disorders; elevated ADMA (asymmetric dimethylarginine) levels can inhibit nitric oxide synthesis, increasing the risk of cardiovascular diseases; carnitine deficiency is linked to certain genetic muscle disorders, impairing fat metabolism and energy production. Additionally, HMB may help slow muscle loss under specific conditions, while taurine intake is associated with improved cardiovascular health. Although some of the effects of these derivatives remain debated, they hold significant potential applications in sports nutrition, neurological regulation, and metabolic health.

References:

[1]. Luckose F, et al. Effects of amino acid derivatives on physical, mental, and physiological activities. Crit Rev Food Sci Nutr. 2015;55(13):1793-807. [Content Brief]

Amino Acid Derivatives Chemical (1)

Amino Acid Derivatives Related Products (1590):

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-W013123

Fmoc-D-Phe(4-CF3)-OH		99.09%
Fmoc-D-Phe(4-CF3)-OH is Phenylalanine derivative. Fmoc-D-Phe(4-CF3)-OH can be used for the research of peptide inhibitors of protein-protein interactions.

HY-W042001

H-DL-Phe(4-Me)-OH		99.74%
H-DL-Phe(4-Me)-OH is a phenylalanine derivative.

HY-W111226

Fmoc-His(3-Me)-OH		≥98.0%
Fmoc-His(3-Me)OH derives Histidine-associating compounds with biological activity. Fmoc-His(3-Me)OH, with Fmoc-citrulline-OH, Fmoc-His(1-Me)-OH together, forms tri-peptides and shows vasodilating effect with EC₅₀s of 2.7-4.7 mM in 1.0 mM Phenylephrine (PE)-contracted aorta rings. Fmoc-His(3-Me)OH (resin) also makes Methyl-His-Gly-Lys (His(3-Me)-Gly-Lys), thus acts as an [Ca²⁺]_i inhibitor. Fmoc-His(3-Me)OH methylates NAHIS02, making it unable to block the Alzheimer's Aβ channel.

HY-W013162

Fmoc-4-Pal-OH		99.67%
Fmoc-4-Pal-OH is an alanine derivative.

HY-W025811

1-(tert-Butyl) 5-methyl L-glutamate hydrochloride		≥98.0%
1-(tert-Butyl) 5-methyl L-glutamate hydrochloride is a glutamic acid derivative.

HY-W009110

(S)-3-(4-Bromophenyl)-3-((tert-butoxycarbonyl)amino)propanoic acid		99.73%
(S)-3-(4-Bromophenyl)-3-((tert-butoxycarbonyl)amino)propanoic acid is a phenylalanine derivative.

HY-W008386

Fmoc-Lys(Fmoc)-OH		99.22%
Fmoc-Lys(Fmoc)-OH is a lysine derivative.

HY-W010871

Fmoc-Cys(4-MeBzl)-OH		99.46%
Fmoc-Cys(4-MeBzl)-OH is a cysteine derivative.

HY-W016012

Glu-Glu		≥98.0%
Glu-Glu is a glutamic acid derivative containing amino and carboxyl groups. Glu-Glu is an analogs of acidic tripeptide and can contribute to calcium absorption.

HY-P4232

H-Gly-Arg-Ala-Asp-Ser-Pro-OH		99.04%
H-Gly-Arg-Ala-Asp-Ser-Pro-OH (GRADSP) is a negative control peptide of GRGDSPK.

HY-W013108

(S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(4-((tert-butoxycarbonyl)amino)phenyl)propanoic acid		≥98.0%
(S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(4-((tert-butoxycarbonyl)amino)phenyl)propanoic acid is a phenylalanine derivative.

HY-Y0533

L-Aspartic acid 4-tert-butyl ester		≥98.0%
L-Aspartic acid 4-tert-butyl ester is an aspartic acid derivative.

HY-W092115

N6-Carbobenzoxy-L-lysine N-carboxyanhydride		98.04%
N6-Carbobenzoxy-L-lysine N-carboxyanhydride is a lysine derivative.

HY-W013207

(S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)pentanoic acid		99.34%
(S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)pentanoic acid is a valine derivative.

HY-34470

N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N-methyl-D-phenylalanine		99.94%
N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N-methyl-D-phenylalanine is a phenylalanine derivative.

HY-I0519

L-Alanine methyl ester hydrochloride		≥98.0%
L-Alanine methyl ester hydrochloride is an alanine derivative.

HY-W013182

(((9H-Fluoren-9-yl)methoxy)carbonyl)-L-aspartic acid		99.54%
(((9H-Fluoren-9-yl)methoxy)carbonyl)-L-aspartic acid is an aspartic acid derivative.

HY-33228

5-Methyl-DL-tryptophan		99.55%
5-Methyl-DL-tryptophan is aamino acids and their derivatives.

HY-W004114

N-Acetyl-L-proline		99.92%
N-Acetyl-L-proline is aproline derivatives.

HY-W048203

N6-(But-2-enoyl)-L-lysine		99.43%
N6-(But-2-enoyl)-L-lysine is a lysine derivative.

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