Amino Acid Derivatives

Amino Acid Derivatives are bioactive molecules formed through chemical modifications or metabolic transformations of amino acids. They are widely present in living organisms and play crucial roles in physiological, psychological, and athletic performance.
The functions of these derivatives primarily include enhancing energy supply, regulating neurotransmitters, promoting fat metabolism, and reducing muscle damage. For example, creatine can increase muscle strength, enhance ATP resynthesis, and improve short-duration high-intensity exercise performance; tyrosine, as a precursor of dopamine and norepinephrine, helps enhance cognitive function and improve mood, particularly in sleep deprivation conditions, exhibiting anti-fatigue effects; carnitine facilitates fatty acid oxidation in the heart and skeletal muscles, improving endurance performance; HMB (β-hydroxy-β-methylbutyrate) reduces muscle breakdown and promotes muscle mass gain; while taurine exhibits antioxidant and antihypertensive properties and reduces oxidative stress induced by exercise.
Metabolic abnormalities or improper supplementation of amino acid derivatives may be associated with various diseases. For instance, tyrosine metabolism disorders can disrupt neurotransmitter balance, potentially leading to depression or stress-related disorders; elevated ADMA (asymmetric dimethylarginine) levels can inhibit nitric oxide synthesis, increasing the risk of cardiovascular diseases; carnitine deficiency is linked to certain genetic muscle disorders, impairing fat metabolism and energy production. Additionally, HMB may help slow muscle loss under specific conditions, while taurine intake is associated with improved cardiovascular health. Although some of the effects of these derivatives remain debated, they hold significant potential applications in sports nutrition, neurological regulation, and metabolic health.

References:

[1]. Luckose F, et al. Effects of amino acid derivatives on physical, mental, and physiological activities. Crit Rev Food Sci Nutr. 2015;55(13):1793-807. [Content Brief]

Amino Acid Derivatives Related Products (1606):

By Effects:	Inhibitor (1) Chemical (1)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-W018062

H-Sar-OtBu.HCl		98.0%
H-Sar-OtBu.HCl is a Glycine (HY-Y0966) derivative.

HY-22002

N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-5-methyl-L-norleucine		99.50%
N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-5-methyl-L-norleucine is a leucine derivative.

HY-W010880

Fmoc-3-Ala(3-benzothienyl)-OH		99.49%
Fmoc-3-Ala(3-benzothienyl)-OH is an alanine derivative.

HY-W008308

H-Ser(Bzl)-OH		99.95%
H-Ser(Bzl)-OH is a serine derivative.

HY-I0519

L-Alanine methyl ester hydrochloride		98.08%
L-Alanine methyl ester hydrochloride is an alanine derivative.

HY-W013182

(((9H-Fluoren-9-yl)methoxy)carbonyl)-L-aspartic acid		99.54%
(((9H-Fluoren-9-yl)methoxy)carbonyl)-L-aspartic acid is an aspartic acid derivative.

HY-W048682

Fmoc-1-methyl-L-histidine		99.20%
Fmoc-1-methyl-L-histidine is a Fmoc protected amino acid and amino acid-containing building block. Fmoc-1-methyl-L-histidine can be used in the production of ε-nitrogen-ligated copper centers in copper nitrite reductases. Fmoc-1-methyl-L-histidine can also be used as an intermediate for peptide synthesis.

HY-77026

(S)-Ethyl 2-amino-4-fluoro-4-methylpentanoate sulfate		99.88%
(S)-Ethyl 2-amino-4-fluoro-4-methylpentanoate sulfate is a leucine derivative.

HY-W006923

O-(tert-Butyl)-N-Fmoc-L-allothreonine		99.86%
O-(tert-Butyl)-N-Fmoc-L-allothreonine is a threonine derivative.

HY-Y1250S2

Fmoc-Gly-OH-2,2-d₂		99.53%
Fmoc-Gly-OH-2,2-d₂ (Fmoc-glycine-2,2-d₂) is the deuterium labeled Fmoc-Gly-OH (HY-Y1250). Fmoc-Gly-OH (Fmoc glycine) is a Fmoc-protected glycine derivative, can be used for the synthesis of compounds.

HY-W048203

N6-(But-2-enoyl)-L-lysine		99.43%
N6-(But-2-enoyl)-L-lysine is a lysine derivative.

HY-W013940

DL-Cystine		≥98.0%
DL-Cystine is a cysteine derivative.

HY-W010162

H-Ala-Ala-OH		98.0%
H-Ala-Ala-OH (L-Alanyl-L-alanine; Ala-Ala) is a nonpolar dipeptide that is absorbed by human intestinal Caco-2 cells. The transport of alanine (Ala), like proton/amino acid symport, can lead to cytoplasmic acidification.

HY-W014258

(R)-2-((tert-Butoxycarbonyl)amino)pent-4-ynoic acid		98.27%
(R)-2-((tert-Butoxycarbonyl)amino)pent-4-ynoic acid is a Glycine (HY-Y0966) derivative. (R)-2-((tert-Butoxycarbonyl)amino)pent-4-ynoic acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-W048913

N2-(((9H-Fluoren-9-yl)methoxy)carbonyl)-N2-(2-((5-sulfonaphthalen-1-yl)amino)ethyl)-L-glutamine		98.12%
N2-(((9H-Fluoren-9-yl)methoxy)carbonyl)-N2-(2-((5-sulfonaphthalen-1-yl)amino)ethyl)-L-glutamine is a glutamine derivative.

HY-W046355

Fmoc-D-Dap(Boc)-OH		99.56%
Fmoc-D-Dap(Boc)-OH is an amino acid derivative with an Fmoc protecting group, which can be used to synthesize bioactive peptide mimetics, such as DOTA-modified peptides and their metal chelates with cancer diagnostic effects.

HY-34738

Boc-β-Ala-ol		99.76%
Boc-β-Ala-ol (3-(Boc-amino)-1-propanol) is an alanine derivative with a Boc protecting group at the N-terminus, which can be used to synthesize bioactive peptide mimics, such as Nα-Benzoyl-α-azaornithine phenyl ester, which has trypsin inhibitory activity.

HY-W007573

(S)-4-(tert-Butoxy)-3-((tert-butoxycarbonyl)amino)-4-oxobutanoic acid		≥98.0%
(S)-4-(tert-Butoxy)-3-((tert-butoxycarbonyl)amino)-4-oxobutanoic acid is an aspartic acid derivative.

HY-W107585

β-Glutamic acid		99.80%
β-Glutamic acid (3-Aminopentanedioic acid) is aβ amino acid.

HY-W040686

2-(Bis(2-(tert-butoxy)-2-oxoethyl)amino)acetic acid
2-(Bis(2-(tert-butoxy)-2-oxoethyl)amino)acetic acid is a Glycine (HY-Y0966) derivative.

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