2. Signaling Pathways
  3. Stem Cell/Wnt
  4. Wnt
  5. Wnt Isoform

Wnt

 

Wnt Related Products (233):

Cat. No. Product Name Effect Purity
  • HY-12238
    IWR-1
    		Inhibitor 99.60%
    IWR-1 is a tankyrase inhibitor which inhibits Wnt/β-catenin signaling pathway.
  • HY-120697
    MSAB
    		Inhibitor 99.77%
    MSAB is a potent and selective inhibitor of Wnt/β-catenin signaling. MSAB binds to β-catenin and promotes its degradation, and specifically downregulates Wnt/β-catenin target genes. MSAB exhibits potent anti-tumor effects selectively on Wnt-dependent cancer cells.
  • HY-N0150
    Monensin sodium
    		Inhibitor ≥98.0%
    Monensin (Monensin A) sodium, an orally active antibiotic, is an ionophore that mediates Na+/H+ exchange. Monensin sodium is a potent Wnt signaling inhibitor. Monensin sodium causes a marked enlargement of the multivesicular bodies (MVBs) and regulates exosome secretion. Monensin sodium can be used for bacterial, fungal, and parasitic infections research, and shows anticancer effects.
  • HY-15659
    Wnt-C59
    		Inhibitor 99.92%
    Wnt-C59 (C59) is a highly potent and oral porcupine (PORCN) inhibitor with an IC50 of 74 pM.
  • HY-101085
    SKL2001
    		Agonist 99.68%
    SKL2001 is an agonist of the Wnt/β-catenin pathway, with anti-cancer activity. SKL2001 stabilizes intracellular β-catenin via disruption of the Axin/β-catenin interaction.
  • HY-168593
    PROTAC KDM3 degrader-1
    		Inhibitor 99.07%
    PROTAC KDM3 degrader-1 (Compound 4) is a CRBN-recruiting PROTAC designed based on the IOX1 (HY-12304) scaffold. PROTAC KDM3 degrader-1 selectively degrades the KDM3A and KDM3B proteins, thereby inhibiting the Wnt/β-catenin signaling pathway. PROTAC KDM3 degrader-1 significantly suppresses the self-renewal capacity of colorectal cancer stem cells and inhibits the growth of colorectal cancer tumors. PROTAC KDM3 degrader-1 is suitable for research on colorectal cancer (Target protein ligand (Pink): HY-12304; linker (Black): HY-22335; Conjugate of E3 ligase ligand and linker: HY-112599; E3 ligase (Blue): HY-41547).
  • HY-102067
    3289-8625
    		Inhibitor
    3289-8625 is an inhibitor of the PDZ domain of Dishevelled (Dvl) protein (Kd=10.6 μM) and has an inhibitory effect on Wnt signaling. In addition, 3289-8625 can slow the growth of prostate cancer PC-3 cells (IC50=12.5 μM). 3289-8625 can be used in the study of embryonic development and cancer.
  • HY-170496
    Fluc-IN-1
    		Inhibitor 98.44%
    Fluc-IN-1 (Compound 3) is an inhibitor for firefly luciferase with an IC50 of 25 nM. Fluc-IN-1 inhibits WNT/β-catenin signaling pathway with an IC50 of 33 nM (measuring by TOPFlash assay).
  • HY-N0020
    Echinacoside
    		Inhibitor 99.88%
    Echinacoside, one of the phenylethanoids isolated from the stems of Cistanche deserticola, effectively inhibits Wnt/β-catenin signaling. Echinacoside elicits neuroprotection by activating Trk receptors and their downstream signal pathways. Antiosteoporotic activity.
  • HY-A0293
    Pyrvinium pamoate
    		Inhibitor 99.75%
    Pyrvinium pamoate is an FDA-approved antihelmintic agent that inhibits WNT pathway signaling.
  • HY-17439
    Salinomycin sodium salt
    		Inhibitor 98.52%
    Salinomycin sodium salt (Salinomycin sodium), an antibiotic potassium ionophore, is a potent inhibitor of Wnt/β-catenin signaling. Salinomycin sodium salt acts on the Wnt/Fzd/LRP complex, blocks Wnt-induced LRP6 phosphorylation, and causes degradation of the LRP6 protein. Salinomycin sodium salt shows selective activity against human cancer stem cells.
  • HY-19987
    BML-284
    		Activator 99.99%
    BML-284 is a potent and cell-permeable Wnt signaling activator. BML-284 induces TCF-dependent transcriptional activity with an EC50 of 700 nM.
  • HY-109049
    Adavivint
    		Inhibitor 98.85%
    Adavivint (SM04690; Lorecivivint) is a potent and selective inhibitor of canonical Wnt signaling, with an EC50 of 19.5 nM via a high-throughput TCF/LEF-reporter assay in SW480 colon cancer cells.
  • HY-32736
    Triptonide
    		Inhibitor 99.89%
    Triptonide (NSC 165677) is a natural product identified in Tripterygium wilfordii Hook F.. Triptonide is a Wnt signaling inhibitor with an IC50 of appropriately 0.3 nM. Triptonide has immunosuppression, anti-inflammatory, anti-fertility, neuroprotective and anti-lymphoma effects.
  • HY-112045
    Foscenvivint
    		Inhibitor 99.56%
    PRI-724 is a selective inhibitor of the CBP/β-catenin interaction.
  • HY-N0279
    Cardamonin
    		Inhibitor 98.38%
    Cardamonin can be found from cardamom, and can target various signaling molecules, transcriptional factors, cytokines and enzymes. Cardamonin can inhibit mTOR, NF-κB, Akt, STAT3, Wnt/β-catenin and COX-2. Cardamonin shows anticancer, anti-inflammatory, antimicrobial and antidiabetic activities.
  • HY-12879
    IWP-4
    		Inhibitor 99.81%
    IWP-4 is a small molecule Wnt inhibitor with an IC50 of 25 nM.
  • HY-N1411
    Platycodin D
    		99.93%
    Platycodin D is a saponin isolated from Platycodon grandiflorus, acts as an activator of AMPKα, with anti-obesity property. WNT/β-catenin pathway mediates the anti-adipogenic effect of platycodin D.
  • HY-11035
    WAY-262611
    		Activator 99.51%
    WAY-262611 is a Wnt/β-Catenin agonist that increases bone formation rate with an EC50 of 0.63 μM in TCF-Luciferase assay. WAY-262611 is also a Dkk1 inhibitor.
  • HY-N0101
    Neohesperidin
    		Activator 98.67%
    Neohesperidin is a flavonoid compound abundant in citrus plants with antioxidant and anti-inflammatory effects. Neohesperidin can upregulate the Wnt/β-catenin signaling pathway, enhance the nuclear translocation of β-catenin and the differentiation of bone marrow stromal cells.