2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Tyrosinase

Tyrosinase

Tyrosinase

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Tyrosinase is a copper-containing metalloprotein belonging to the type-3 copper protein family, together with haemocyanins and catechol oxidases. Tyrosinases are the catalysts in mammals responsible for the formation of melanin in skin and hair color, as well as browning in fruit and vegetables following cell damage.

Tyrosinases are found in various prokaryotes as well as in plants, fungi, arthropods, and mammals and are responsible for pigmentation, wound healing, radiation protection, and primary immune response. Tyrosinases perform two sequential enzymatic reactions: hydroxylation of monophenols and oxidation of diphenols to form quinones which polymerize spontaneously to melanin. In plants, sponges, and many invertebrates, tyrosinases are important for wound healing and primary immune responses; in arthropods, they play a role in sclerotization, and in bacteria, tyrosinases protect DNA from UV damage.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-162524
    Tyrosinase-IN-28
    		Inhibitor
    Tyrosinase-IN-28 (Compound 4l) is an inhibitor for tyrosinase with IC50 of 72.55 μM, by affecting both substrate binding and enzyme catalysis.
    Tyrosinase-IN-28
  • HY-W012595R
    Benzylideneacetone (Standard)
    		Inhibitor
    Benzylideneacetone (Standard) is the analytical standard of Benzylideneacetone. This product is intended for research and analytical applications. Benzylideneacetone (Benzalacetone) is an orally active antibiotic, tyrosinase inhibitor, phospholipase A2 inhibitor, and immunosuppressant. Benzylideneacetone has antibacterial activity against some gram-negative plant-pathogenic bacteria. Benzylideneacetone can also be used in the synthesis of chemicals and drugs, and as a flavoring additive for some foods.
    Benzylideneacetone (Standard)
  • HY-158021
    Tyrosinase-IN-26
    		Inhibitor
    Tyrosinase-IN-26 (compound 13) is a uncompetitive tyrosinase inhibitor with the an IC50 value of 68.86 µM. Tyrosinase-IN-26 can suppresses melanogenesis.
    Tyrosinase-IN-26
  • HY-156370
    Tyrosinase-IN-15
    		Inhibitor
    Tyrosinase-IN-15 (Compound 39) is a tyrosinase inhibitor (IC50: 7.12 μM, Ki: 11.8 μM).
    Tyrosinase-IN-15
  • HY-P6294
    Pseudostellarin G
    		Inhibitor
    Pseudostellarin G is a natural cyclic octapeptide. Pseudostellarin G has the activity of inhibiting tyrosinase. Pseudostellarin G can inhibit the production of melanin.
    Pseudostellarin G
  • HY-151977
    Tyrosinase-IN-7
    		Inhibitor
    Tyrosinase-IN-7 is a potent tyrosinase inhibitor with an IC50 value of 1.57 µM. Tyrosinase-IN-7 inhibits cell growth with low cytotoxicity.
    Tyrosinase-IN-7
  • HY-N3665
    Cyclocommunol
    		Inhibitor
    Cyclocommunol is a prenylflavonoid with antityrosinase and antiplatelet activitie, can be solated from breadfruit. Cyclocommunol exerts anti-tumor activity and inhibits the growth of human hepatoma and gastric cancer cells with IC50 values between 16 and 80 µM. Cyclocommunol shows proapoptotic effect on oral squamous cell carcinoma (OSCC).
    Cyclocommunol
  • HY-162889
    Tyrosinase-IN-36
    		Inhibitor
    Tyrosinase-IN-36 is a moderate Tyrosinase inhibitor, with an inhibition percentage of 42.75% at 100 μM compared to kojic acid, and it exhibits antioxidant activity.
    Tyrosinase-IN-36
  • HY-W003607R
    3-O-Ethyl-L-ascorbic acid (Standard)
    		Inhibitor
    3-O-Ethyl-L-ascorbic acid (Standard) is the analytical reference standard for 3-O-Ethyl-L-ascorbic acid. 3-O-Ethyl-L-ascorbic acid is a stable derivative of vitamin C and a cosmetic tyrosinase inhibitor. 3-O-Ethyl-L-ascorbic acid has antioxidant, anti-aging, and skin-whitening activities. 3-O-Ethyl-L-ascorbic acid is often used in the study of cosmetic.
    3-O-Ethyl-L-ascorbic acid (Standard)
  • HY-P0096
    Decapeptide-12
    		Inhibitor
    Decapeptide-12, a small oligopeptide, is a tyrosinase inhibitor that interacts with C-terminal residue of tyrosinase (Kd: 61.1 μM). Decapeptide-12 is a competitive inhibitor of mushroom tyrosinase (IC50: 40 μM). Decapeptide-12 also increases transcription of SIRT. Decapeptide-12 reduces melanin content in melanocytes. Decapeptide-12 is used for the research of melanogenesis, senescence, inflammation .
    Decapeptide-12
  • HY-143452
    MtTMPK-IN-4
    		Inhibitor
    MtTMPK-IN-4 (compound 2), a para-piperidine, is a potent mycobacterium tuberculosis thymidylate kinase (MtTMPK) inhibitor with an IC50 of 6.1 μM. MtTMPK-IN-4 is a potent tyrosinase inhibitor. MtTMPK-IN-4 is a potent antibacterial agent.
    MtTMPK-IN-4
  • HY-N10016
    Chlorogenic acid butyl ester
    		Inhibitor
    Chlorogenic acid butyl ester, a caffeoylquinic acid, is a potent melanogenesis inhibitor. Chlorogenic acid butyl ester inhibits the expression of microphtalmia-associated transcription factor (MITF), tyrosinase, tyrosinerelated protein 1 (TRP-1), and TRP-2. Chlorogenic acid butyl ester also shows antioxidant activity.
    Chlorogenic acid butyl ester
  • HY-159917
    PPL agonist-1
    		Activator
    PPL agonist-1 is a highly selective Periplakin (PPL) agonist that increases cAMP levels by regulating PPL, thereby enhancing MITF expression and promoting melanin synthesis. Furthermore, PPL agonist-1 facilitates melanin production by regulating tryptophan metabolism. Compared to Ruxolitinib (HY-50856), PPL agonist-1 demonstrates superior efficacy. PPL agonist-1 holds potential for research into vitiligo treatment.
    PPL agonist-1
  • HY-N10437
    6-Acetylnimbandiol
    		Inhibitor
    6-Acetylnimbandiol (6-O-Acetylnimbandiol) is a non-cytotoxic tyrosinase inhibitor (IC50=69.85 μM) that effectively inhibits melanin production and MITF expression. 6-Acetylnimbandiol can be used in melanoma research.
    6-Acetylnimbandiol
  • HY-N0646R
    Silydianin (Standard)
    		Inhibitor
    Silydianin (Standard) is the analytical standard of Silydianin (HY-N0646). This product is intended for research and analytical applications. Silydianin is a flavonolignan. Silydianin can be obtained from Silybum marianum. Silydianin inhibits PTP1B with an IC50 of 17.38 μM. Silydianin inhibits both monophenolase and diphenolase of tyrosinase significantly, with IC50s of 2.6 μM and 16.5 μM, respectively. Silydianin induces Apoptosis and reduces cytokines (IL-4 and IL-5). Silymarin has antioxidant, cytoprotective and immunomodulatory effects. Silydianin has antitumor activity against prostate cancer. Silymarin can be used in allergic asthma research.
    Silydianin (Standard)
  • HY-N1658
    2,3-Dihydroisoginkgetin
    		Inhibitor
    2,3-Dihydroisoginkgetin, a biflavonoid, is a inhibitor of Tyrosinase, with 36.84% inhibition at 0.1 mM. 2,3-Dihydroisoginkgetin shows less toxicity in HEMn (human epidermal melanocytes) cells, with an IC50 of 86.16 μM.
    2,3-Dihydroisoginkgetin
  • HY-P990471
    Anti-MSPR/RON/CD136 Antibody
    The Anti-MSPR/RON/CD136 Antibody is a human antibody expressed in CHO, targeting MSPR/RON/CD136. The Anti-MSPR/RON/CD136 Antibody is equipped with huIgG1 heavy chain and huκ light chain, with a predicted molecular weight (MW) of 145.74 kDa. The isotype control for the Anti-MSPR/RON/CD136 Antibody can refer to Human IgG1 kappa, Isotype Control (HY-P99001).
    Anti-MSPR/RON/CD136 Antibody
  • HY-N1780R
    3,4-Dimethoxyphenol (Standard)
    		Inhibitor
    Lithocholic acid (Standard) is the analytical standard of Lithocholic acid. This product is intended for research and analytical applications. Lithocholic acid is a toxic secondary bile acid that can promote intrahepatic cholestasis and promote tumorigenesis. Lithocholic acid is also a FXR antagonist and a PXR/SXR agonist.
    3,4-Dimethoxyphenol (Standard)
  • HY-N3654
    Cyclo(l-Pro-d-Leu)
    		Inhibitor
    Cyclo(l-Pro-d-Leu) (compound 11) is a collagenase inhibitor that can be extracted from R. atalantica and also exhibits a mild tyrosinase inhibitory effect.
    Cyclo(l-Pro-d-Leu)
  • HY-143451
    Tyrosinase-IN-4
    		Inhibitor
    Tyrosinase-IN-4 (compound 34) is a potent inhibitor of tyrosinase. Tyrosinase is a copper-containing metalloenzyme that is responsible for the rate-limiting catalytic step in the melanin biosynthesis and enzymatic browning. Tyrosinase-IN-4 has the potential for the research of skin whitening agents and food preservatives.
    Tyrosinase-IN-4
Cat. No. Product Name / Synonyms Application Reactivity