Tyrosinase

Related Products

Tyrosinase is a copper-containing metalloprotein belonging to the type-3 copper protein family, together with haemocyanins and catechol oxidases. Tyrosinases are the catalysts in mammals responsible for the formation of melanin in skin and hair color, as well as browning in fruit and vegetables following cell damage.

Tyrosinases are found in various prokaryotes as well as in plants, fungi, arthropods, and mammals and are responsible for pigmentation, wound healing, radiation protection, and primary immune response. Tyrosinases perform two sequential enzymatic reactions: hydroxylation of monophenols and oxidation of diphenols to form quinones which polymerize spontaneously to melanin. In plants, sponges, and many invertebrates, tyrosinases are important for wound healing and primary immune responses; in arthropods, they play a role in sclerotization, and in bacteria, tyrosinases protect DNA from UV damage.

Tyrosinase Related Products (243)
Antibodies (9)

By Effects:	Substrates (3) Inhibitors (211) Degrader (1) Antagonist (1) Activators (8) Modulator (1) Inducer (1)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-W007671

H-Tyr-OMe	Substrate	99.53%
H-Tyr-OMe is an endogenous metabolite. H-Tyr-OMe quenches the fluorescence of carbon dots by oxidizing the phenolic hydroxyl group to quinone under the catalysis of Tyrosinase, and its amino and thiol binding ability can respond to changes in the concentration of biothiols.

HY-155978

RDN2150	Inhibitor
RDN2150 (Compound 25) is a ZAP-70 inhibitor (IC₅₀: 14.6 nM). RDN2150 covalently binds to the C346 residue of ZAP-70. RDN2150 inhibits the expression of CD25 and CD69, and inhibits CD4⁺ T cell activation. RDN2150 can be used for research of psoriasis.

HY-W015967R

Glycolic acid (Standard)	Inhibitor
Glycolic acid (Standard) is the analytical standard of Glycolic acid. This product is intended for research and analytical applications. Glycolic acid is an inhibitor of tyrosinase, suppressing melanin formation and lead to a lightening of skin colour.

HY-N0619A

cis-Mulberroside A	Inhibitor
cis-Mulberroside A (Mulberroside D) is the cis-isomer of Mulberroside A. Mulberroside A is one of the main bioactive constituent in mulberry (Morus alba L.). Mulberroside A decreases the expressions of TNF-α, IL-1β, and IL-6 and inhibits the activation of NALP3, caspase-1, and NF-κB and the phosphorylation of ERK, JNK, and p38, exhibiting anti-inflammatory and anti-apoptotic effects. Mulberroside A shows inhibitory activity against mushroom tyrosinase with an IC₅₀ of 53.6 μM.

HY-Y0444S1

D-Tyrosine-d₄	Inhibitor	≥99.0%
D-Tyrosine-d₄ is the deuterium labeled D-Tyrosine (HY-Y0444). D-Tyrosine is the D-isomer of tyrosine. D-Tyrosine negatively regulates melanin synthesis by inhibiting tyrosinase activity. D-Tyrosine inhibits biofilm formation and trigger the self-dispersal of biofilms without suppressing bacterial growth.

HY-Y0444S2

D-Tyrosine-d₇	Inhibitor
D-Tyrosine-d₇ is the deuterium labeled D-Tyrosine (HY-Y0444). D-Tyrosine is the D-isomer of tyrosine. D-Tyrosine negatively regulates melanin synthesis by inhibiting tyrosinase activity. D-Tyrosine inhibits biofilm formation and trigger the self-dispersal of biofilms without suppressing bacterial growth.

HY-W013636C

2-Ketoglutaric acid potassium	Inhibitor	≥98.0%
2-Ketoglutaric acid (Alpha-Ketoglutaric acid) potassium is an intermediate in the production of ATP or GTP in the Krebs cycle. 2-Ketoglutaric acid potassium also acts as the major carbon skeleton for nitrogen-assimilatory reactions. 2-Ketoglutaric acid potassium is a reversible inhibitor of tyrosinase with an IC₅₀ value of 15 mM.

HY-W013636S1

2-Ketoglutaric acid-d₄
2-Ketoglutaric acid-d₄ (Alpha-Ketoglutaric acid-d₄) is the deuterium labeled 2-Ketoglutaric acid (HY-W013636). 2-Ketoglutaric acid Sodium is an intermediate in the production of ATP or GTP in the Krebs cycle. 2-Ketoglutaric acid Sodium also acts as the major carbon skeleton for nitrogen-assimilatory reactions. 2-Ketoglutaric acid Sodium is a reversible inhibitor of tyrosinase (IC₅₀=15 mM).

HY-N1238

β-Sitostenone	Inhibitor
β-Sitostenone is a sterols that can be isolated from Cochlospermum vitifolium.β-Sitostenone inhibits tyrosinase activity, and has anti-melanogenic and anti-tumor activities.

HY-Y0729

4-Chlorocinnamic acid	Inhibitor	99.98%
4-Chlorocinnamic acid has inhibitory effects on tyrosinase. 4-Chlorocinnamic acid has antibacterial activity. 4-Chlorocinnamic acid also inhibits Colletotrichum gloeosporioides growth.

HY-W060074

1-Acetyl-β-carboline	Activator
1-Acetyl-β-carboline is a metabolite of Streptomyces kasugaensis and antibacterial agent. 1-Acetyl-β-carboline increases tyrosinase activity, reduces ERK phosphorylation. 1-Acetyl-β-carboline exhibits antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA) strains with MICs ranging from 128 to 256 ug/mL. 1-Acetyl-β-carboline increases the melanin.

HY-129137

Cyanidin 3-sophoroside chloride	Inhibitor	99.6%
Cyanidin 3-sophoroside chloride is a potent non-competitive reversible polyphenol oxidase (PPO)/Tyrosinase inhibitor. Also, Cyanidin 3-sophoroside chloride can be used as an anti-browning agent to inhibit the degree of PPO browning, enhance the antioxidant damage capacity of fruits and prolong the storage period.

HY-N0192R

Arbutin (Standard)	Inhibitor
Arbutin (Standard) is the analytical standard of Arbutin. This product is intended for research and analytical applications. Arbutin (β-Arbutin) is a competitive inhibitor of tyrosinase, with Kiapp values of 1.42 mM for monophenolase; 0.9 mM for diphenolase. Arbutin is also used as depigmenting agents. Arbutin is a natural polyphenol isolated from the bearberry plant Arctostaphylos uvaursi, possesses with anti-oxidant, anti-inflammatory and anti-tumor properties.

HY-W013636S3

2-Ketoglutaric acid-¹³C	Inhibitor
2-Ketoglutaric acid-¹³C (Alpha-Ketoglutaric acid-¹³C) is a ¹³C labeled 2-Ketoglutaric acid (HY-W013636). 2-Ketoglutaric acid (Alpha-Ketoglutaric acid) is an intermediate in the production of ATP or GTP in the Krebs cycle. 2-Ketoglutaric acid also acts as the major carbon skeleton for nitrogen-assimilatory reactions. 2-Ketoglutaric acid is a reversible inhibitor of tyrosinase (IC₅₀=15 mM).

HY-W015782

4-Ethylresorcinol	Substrate	99.71%
4-Ethylresorcinol is a derivative of resorcinol and can serve as a substrate for tyrosinase. 4-Ethylresorcinol has anti-hyperpigmentation and antioxidant effects and can inhibit melanin synthesis. 4-Ethylresorcinol has potential whitening value.

HY-143450

Tyrosinase-IN-3	Inhibitor
Tyrosinase-IN-3 (compound 54) is a potent inhibitor of tyrosinase. Tyrosinase is a copper-containing metalloenzyme that is responsible for the rate-limiting catalytic step in the melanin biosynthesis and enzymatic browning. Tyrosinase-IN-3 has the potential for the research of skin whitening agents and food preservatives.

HY-137000

4-Prenyloxyresveratrol	Inhibitor
4-Prenyloxyresveratrol, an oxyresveratrol derivative, shows potent tyrosinase inhibitory activity with an IC₅₀ of 0.90 μM.

HY-161612

Mycosporine 2 glycine	Inhibitor
Mycosporine 2 glycine is an inhibitor for tyrosinase-related protein 1 (TYRP1), that binds TYRP1 with good affinity and stability. Mycosporine 2 glycine stimulates mild to moderate skin and ocular irritancy. Mycosporine 2 glycine is utilized in sunscreen products to cure hyperpigmentation-related diseases.

HY-143459

Tyrosinase-IN-5	Inhibitor
Tyrosinase-IN-5 (compound 16c) is a potent inhibitor of tyrosinase with an IC₅₀ of 0.02 μM. Tyrosinase-IN-5 efficiently suppresses the melanogenesis without significant toxicity on cells.

HY-149404

Tyrosinase-IN-12		99.83%
Non-competitive tyrosinase inhibitor (Tyrosinase-IN-12) is a potent, non-competitive tyrosinase inhibitor with an IC₅₀ value of 49.33 ± 2.64 µM and K_i value of 31.25 ± 0.25 µM. Non-competitive tyrosinase inhibitor (Tyrosinase-IN-12) have the highest radical scavenging activity to reduce the production of reactive oxygen species (ROS) with an IC₅₀ value of 25.39 ± 0.77 µM. Non-competitive tyrosinase inhibitor (Tyrosinase-IN-12) can be used for anti-browning substances in the food and agricultural sectors.

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Tyrosinase

Tyrosinase

Tyrosinase Related Products (243)

Antibodies (9)

Tyrosinase Related Products (243):