2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Tyrosinase

Tyrosinase

Tyrosinase

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Tyrosinase is a copper-containing metalloprotein belonging to the type-3 copper protein family, together with haemocyanins and catechol oxidases. Tyrosinases are the catalysts in mammals responsible for the formation of melanin in skin and hair color, as well as browning in fruit and vegetables following cell damage.

Tyrosinases are found in various prokaryotes as well as in plants, fungi, arthropods, and mammals and are responsible for pigmentation, wound healing, radiation protection, and primary immune response. Tyrosinases perform two sequential enzymatic reactions: hydroxylation of monophenols and oxidation of diphenols to form quinones which polymerize spontaneously to melanin. In plants, sponges, and many invertebrates, tyrosinases are important for wound healing and primary immune responses; in arthropods, they play a role in sclerotization, and in bacteria, tyrosinases protect DNA from UV damage.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-N1780
    3,4-Dimethoxyphenol
    		Inhibitor 99.97%
    3,4-Dimethoxyphenol is a plant-derived phenylpropanoid compound and can use as a whitening agent in cosmetics. 3,4-Dimethoxyphenol has tyrosinase-inhibiting activity. 3,4-Dimethoxyphenol has potent antioxidant effect isolated from the bacterial fermentation broth.
    3,4-Dimethoxyphenol
  • HY-108935
    Lavendustin B
    		Inhibitor 98.02%
    Lavendustin B is an inhibitor of HIV-1 integrase interaction with LEDGF/p75 with an IC50 of 94.07 μM. Lavendustin B is an ATP-competitive GLUT1 inhibitor with a Ki of 15 μM. Lavendustin B is also a weak inhibitor of tyrosine kinases.
    Lavendustin B
  • HY-N2983
    Cajanin
    		Inhibitor 99.96%
    Cajanin is a potent and orally active anti-melanogenic agent. Cajanin shows antiproliferative activity in MNT1 Cells. Cajanin efficiently decreases the melanin content. Cajanin down-regulates the mRNA and protein expression levels of MITF, tyrosinase, TRP-1 and Dct (TRP-2). Cajanin induces cell cycle arrest at G2/M and S phase. Cajanin stimulates osteoblast proliferation. Cajanin has the potential for the research of human hyperpigmented disorders and menopausal osteoporosis.
    Cajanin
  • HY-N3200
    Neorauflavane
    		Inhibitor
    Neorauflavane is a potent tyrosinase inhibitor derived from Campylotropis hirtella, with an IC50 value of 30 nM for tyrosinase monophenolase activity and an IC50 value of 500 nM for diphenolase activity. Neorauflavane can effectively reduce the melanin content of B16 melanoma cells.
    Neorauflavane
  • HY-N0136B
    (-)-Taxifolin
    		Inhibitor 98.98%
    (-)-Taxifolin is the less active enantiomer of Taxifolin. Taxifolin exhibits important anti-tyrosinase activity. Taxifolin exhibits significant inhibitory activity against collagenase with an IC50 value of 193.3 μM. Taxifolin is an important natural compound with antifibrotic activity. Taxifolin is a free radical scavenger with antioxidant capacity.
    (-)-Taxifolin
  • HY-N3103
    p-Coumaric Acid Ethyl Ester
    		99.19%
    p-Coumaric Acid Ethyl Ester (Ethyl (E)-p-hydroxycinnamate; Ethyl trans-4-hydroxycinnamate) is a non-competitive, reversible inhibitor of tyrosinase (IC50=4.89 μg/mL, Ki=1.83 μg/mL), which can quench the intrinsic fluorescence of the enzyme. p-Coumaric Acid Ethyl Ester changes the binding affinity of L-tyrosine by inducing conformational changes in the catalytic domain of tyrosinase, and does not bind to the copper ion of the enzyme. p-Coumaric Acid Ethyl Ester is used in the development of medicines, cosmetics and fruit preservation products using pollen.
    p-Coumaric Acid Ethyl Ester
  • HY-N0136S1
    (±)-Taxifolin-13C3
    		Inhibitor 99.63%
    (±)-Taxifolin-13C3 ((±)-Dihydroquercetin-13C3) is a derivative of (±)-Taxifolin, labeled with 13C3. (±)-Taxifolin is the racemate of Taxifolin. Taxifolin exhibits important anti-tyrosinase activity. Taxifolin exhibits significant inhibitory activity against collagenase with an IC50 value of 193.3 μM. Taxifolin is an important natural compound with antifibrotic activity. Taxifolin is a free radical scavenger with antioxidant capacity.
    (±)-Taxifolin-<sup>13</sup>C<sub>3</sub>
  • HY-N11063
    Obtusifolin-2-O-glucoside
    		Inhibitor
    Obtusifolin-2-O-glucoside (compound 7) is a Tyrosinase inhibitor (IC50=9.2 μM). Obtusifolin-2-O-glucoside can be isolated from cassia seed.
    Obtusifolin-2-O-glucoside
  • HY-P3813
    Tyrosinase (206-214), human
    		99.19%
    Tyrosinase (206-214), human (AFLPWHRLF), a 9-amino acid peptide, is a tyrosinase epitope. Tyrosinase (206-214), human can be recognized by HLA-A24 restricted, tumor-infiltrating lymphocytes (TIL).
    Tyrosinase (206-214), human
  • HY-N3748
    Dihydromorin
    		Inhibitor 99.96%
    Dihydromorin, a natural flavanonol compound, is a tyrosinase inhibitor.
    Dihydromorin
  • HY-P99375
    Narnatumab
    		Inhibitor 99.93%
    Narnatumab (IMC-RON8) is a neutralizing human monoclonal antibody that blocks RON binding to its ligand, macrophage-stimulating protein (MSP), with a Kd of 32 pM. Narnatumab can be used for the research of cancer.
    Narnatumab
  • HY-21290
    SU-4942
    		Modulator 98.55%
    SU-4942 is a tyrosine kinase signal signal modulator. SU-4942 inhibits VEGF- and endothelial cell growth factor (ECGF)-induced mitogenesis in endothelial cells (US5792783A).
    SU-4942
  • HY-138885
    Tryptamine guanosine carbamate
    		Inhibitor 99.79%
    Tryptamine guanosine carbamate (TpGc) is a selective HINT1 (histidine triad nucleotide-binding protein 1) inhibitor (Ki=34 μM, Kd=3.65 μM). Tryptamine guanosine carbamate significantly enhances morphine antinociception while preventing the development of tolerance.
    Tryptamine guanosine carbamate
  • HY-157123
    Tyrosinase-IN-18
    		Inhibitor 99.33%
    Tyrosinase-IN-18 (compound 6) is a potent tyrosinase inhibitor. Tyrosinase-IN-18 inhibits melanogenesis in B16F10 mammalian cells. Tyrosinase-IN-18 has strong antioxidant activities against ROS, ABTS+, and DPPH radicals.
    Tyrosinase-IN-18
  • HY-149207
    Tyrosinase-IN-11
    		Inhibitor 98.12%
    Tyrosinase-IN-11 is a potent tyrosinase inhibitor with IC50s of 50 nM and 64 nM for L-tyrosinase and L-dopa, respectively. Tyrosinase-IN-11 has significant antioxidant activity and low cytotoxicity. Tyrosinase-IN-11 has the potential for skin hyperpigmentation research.
    Tyrosinase-IN-11
  • HY-P1919
    [Asp371]-Tyrosinase (369-377), human
    		99.66%
    Tyrosinase 369-377, human is a HLA-A2.1-restricted epitope derived from tyrosinase, has been used to develop tumor-targeted vaccines with mixed efficacy.
    [Asp371]-Tyrosinase (369-377), human
  • HY-N6244
    Isolindleyin
    		Inhibitor ≥99.0%
    Isolindleyin, a butyrophenone, is a tyrosinase inhibitor, with a Kd of 54.8 μM for human tyrosinase. Isolindleyin exhibits anti-inflammatory, analgesic and anti-melanogenic activities.
    Isolindleyin
  • HY-N12810
    Sanggenon O
    		Inhibitor
    Sanggenon O is a mushroom tyrosinase inhibitor that can be isolated from Morus nigra, with an IC50 value of 1.15 μM.
    Sanggenon O
  • HY-W019829
    Polyphyllin C
    		Inhibitor
    Polyphyllin C (compound 2) is a spirostanol saponin. Polyphyllin C exhibits mild (IC50=36.87 µM) activities against the tyrosinase and moderate (IC50=1.59 µg/mL) antileishmanial activities.
    Polyphyllin C
  • HY-W099579
    Kojic acid dipalmitate
    		Inhibitor 99.84%
    Kojic acid dipalmitate (Kojic dipalmitate) is a derivative of Kojic acid (HY-W050154), a fungal metabolite that can be produced by species of Aspergillus, Acetobacter and Penicillium. Kojic acid dipalmitate is a slow and reversible competitive inhibitor of tyrosinase. Kojic acid dipalmitate can be used for skin‐lightening agent research.
    Kojic acid dipalmitate
Cat. No. Product Name / Synonyms Application Reactivity