Tyrosinase

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Tyrosinase is a copper-containing metalloprotein belonging to the type-3 copper protein family, together with haemocyanins and catechol oxidases. Tyrosinases are the catalysts in mammals responsible for the formation of melanin in skin and hair color, as well as browning in fruit and vegetables following cell damage.

Tyrosinases are found in various prokaryotes as well as in plants, fungi, arthropods, and mammals and are responsible for pigmentation, wound healing, radiation protection, and primary immune response. Tyrosinases perform two sequential enzymatic reactions: hydroxylation of monophenols and oxidation of diphenols to form quinones which polymerize spontaneously to melanin. In plants, sponges, and many invertebrates, tyrosinases are important for wound healing and primary immune responses; in arthropods, they play a role in sclerotization, and in bacteria, tyrosinases protect DNA from UV damage.

Tyrosinase Related Products (245)
Antibodies (9)

By Effects:	Substrates (3) Inhibitors (213) Degrader (1) Antagonist (1) Activators (8) Modulator (1) Inducer (1)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-N8223

Viscumneoside III	Inhibitor	98.74%
Viscumneoside III, a dihydroflavone O-glycoside, is a potent tyrosinase inhibitor with an IC₅₀ of 0.5 mM. Viscumneoside III has anti-angina pectoris.

HY-21290

SU-4942	Modulator	99.60%
SU-4942 is a tyrosine kinase signal signal modulator. SU-4942 inhibits VEGF- and endothelial cell growth factor (ECGF)-induced mitogenesis in endothelial cells (US5792783A).

HY-N1780

3,4-Dimethoxyphenol	Inhibitor	99.97%
3,4-Dimethoxyphenol is a plant-derived phenylpropanoid compound and can use as a whitening agent in cosmetics. 3,4-Dimethoxyphenol has tyrosinase-inhibiting activity. 3,4-Dimethoxyphenol has potent antioxidant effect isolated from the bacterial fermentation broth.

HY-138885

Tryptamine guanosine carbamate	Inhibitor	99.79%
Tryptamine guanosine carbamate (TpGc) is a selective HINT1 (histidine triad nucleotide-binding protein 1) inhibitor (K_i=34 μM, K_d=3.65 μM). Tryptamine guanosine carbamate significantly enhances morphine antinociception while preventing the development of tolerance.

HY-108935

Lavendustin B	Inhibitor	98.02%
Lavendustin B is an inhibitor of HIV-1 integrase interaction with LEDGF/p75 with an IC₅₀ of 94.07 μM. Lavendustin B is an ATP-competitive GLUT1 inhibitor with a K_i of 15 μM. Lavendustin B is also a weak inhibitor of tyrosine kinases.

HY-N1750

3-(2,4-Dihydroxyphenyl)propanoic acid	Inhibitor	99.46%
3-(2,4-Dihydroxyphenyl)propanoic acid (DPPacid) is a potent and competitive tyrosinase inhibitor, inhibits L-Tyrosine and DL-DOPA with an IC₅₀ and a K_i of 3.02 μM and 11.5 μM, respectively.

HY-N2983

Cajanin	Inhibitor	99.96%
Cajanin is a potent and orally active anti-melanogenic agent. Cajanin shows antiproliferative activity in MNT1 Cells. Cajanin efficiently decreases the melanin content. Cajanin down-regulates the mRNA and protein expression levels of MITF, tyrosinase, TRP-1 and Dct (TRP-2). Cajanin induces cell cycle arrest at G2/M and S phase. Cajanin stimulates osteoblast proliferation. Cajanin has the potential for the research of human hyperpigmented disorders and menopausal osteoporosis.

HY-N0136B

(-)-Taxifolin	Inhibitor	98.98%
(-)-Taxifolin is the less active enantiomer of Taxifolin. Taxifolin exhibits important anti-tyrosinase activity. Taxifolin exhibits significant inhibitory activity against collagenase with an IC₅₀ value of 193.3 μM. Taxifolin is an important natural compound with antifibrotic activity. Taxifolin is a free radical scavenger with antioxidant capacity.

HY-N3103

p-Coumaric Acid Ethyl Ester		99.19%
p-Coumaric Acid Ethyl Ester (Ethyl (E)-p-hydroxycinnamate; Ethyl trans-4-hydroxycinnamate) is a non-competitive, reversible inhibitor of tyrosinase (IC₅₀=4.89 μg/mL, K_i=1.83 μg/mL), which can quench the intrinsic fluorescence of the enzyme. p-Coumaric Acid Ethyl Ester changes the binding affinity of L-tyrosine by inducing conformational changes in the catalytic domain of tyrosinase, and does not bind to the copper ion of the enzyme. p-Coumaric Acid Ethyl Ester is used in the development of medicines, cosmetics and fruit preservation products using pollen.

HY-N0136S1

(±)-Taxifolin-¹³C₃	Inhibitor	99.63%
(±)-Taxifolin-13C3 ((±)-Dihydroquercetin-13C3) is a derivative of (±)-Taxifolin, labeled with 13C3. (±)-Taxifolin is the racemate of Taxifolin. Taxifolin exhibits important anti-tyrosinase activity. Taxifolin exhibits significant inhibitory activity against collagenase with an IC₅₀ value of 193.3 μM. Taxifolin is an important natural compound with antifibrotic activity. Taxifolin is a free radical scavenger with antioxidant capacity.

HY-N11063

Obtusifolin-2-O-glucoside	Inhibitor
Obtusifolin-2-O-glucoside (compound 7) is a Tyrosinase inhibitor (IC₅₀=9.2 μM). Obtusifolin-2-O-glucoside can be isolated from cassia seed.

HY-P3813

Tyrosinase (206-214), human		99.19%
Tyrosinase (206-214), human (AFLPWHRLF), a 9-amino acid peptide, is a tyrosinase epitope. Tyrosinase (206-214), human can be recognized by HLA-A24 restricted, tumor-infiltrating lymphocytes (TIL).

HY-N3748

Dihydromorin	Inhibitor	99.96%
Dihydromorin, a natural flavanonol compound, is a tyrosinase inhibitor.

HY-W013636C

2-Ketoglutaric acid potassium	Inhibitor	≥98.0%
2-Ketoglutaric acid (Alpha-Ketoglutaric acid) (potassium) is an intermediate in the production of ATP or GTP in the Krebs cycle. 2-Ketoglutaric acid potassium is a reversible and orally active inhibitor of tyrosinase with an IC₅₀ value of 15 mM. 2-Ketoglutaric acid potassium also acts as the major carbon skeleton for nitrogen-assimilatory reactions. 2-Ketoglutaric acid potassium significantly suppresses abnormal intestinal permeability, delocalization of tight junction proteins from the intestinal cells, expression of TNFα in vitro and in vivo. 2-Ketoglutaric acid potassium directly binds to TAK1, and inhibits the TRAF6-TAK1 interaction. 2-Ketoglutaric acid potassium also alleviates inflammatory bowel disease (IBD) symptoms and gut microbiota dysbiosis, evident by the improvements in the intestine length.

HY-N1238

β-Sitostenone	Inhibitor
β-Sitostenone is a sterols that can be isolated from Cochlospermum vitifolium.β-Sitostenone inhibits tyrosinase activity, and has anti-melanogenic and anti-tumor activities.

HY-N0192R

Arbutin (Standard)	Inhibitor
Arbutin (Standard) is the analytical standard of Arbutin. This product is intended for research and analytical applications. Arbutin (β-Arbutin) is a competitive inhibitor of tyrosinase, with Kiapp values of 1.42 mM for monophenolase; 0.9 mM for diphenolase. Arbutin is also used as depigmenting agents. Arbutin is a natural polyphenol isolated from the bearberry plant Arctostaphylos uvaursi, possesses with anti-oxidant, anti-inflammatory and anti-tumor properties.

HY-W013636S3

2-Ketoglutaric acid-¹³C	Inhibitor
2-Ketoglutaric acid-¹³C (Alpha-Ketoglutaric acid-¹³C) is a ¹³C labeled 2-Ketoglutaric acid (HY-W013636). 2-Ketoglutaric acid (Alpha-Ketoglutaric acid) is an intermediate in the production of ATP or GTP in the Krebs cycle. 2-Ketoglutaric acid also acts as the major carbon skeleton for nitrogen-assimilatory reactions. 2-Ketoglutaric acid is a reversible inhibitor of tyrosinase (IC₅₀=15 mM).

HY-157123

Tyrosinase-IN-18	Inhibitor	99.33%
Tyrosinase-IN-18 (compound 6) is a potent tyrosinase inhibitor. Tyrosinase-IN-18 inhibits melanogenesis in B16F10 mammalian cells. Tyrosinase-IN-18 has strong antioxidant activities against ROS, ABTS⁺, and DPPH radicals.

HY-149207

Tyrosinase-IN-11	Inhibitor	98.12%
Tyrosinase-IN-11 is a potent tyrosinase inhibitor with IC₅₀s of 50 nM and 64 nM for L-tyrosinase and L-dopa, respectively. Tyrosinase-IN-11 has significant antioxidant activity and low cytotoxicity. Tyrosinase-IN-11 has the potential for skin hyperpigmentation research.

HY-P1919

[Asp371]-Tyrosinase (369-377), human		99.66%
Tyrosinase 369-377, human is a HLA-A2.1-restricted epitope derived from tyrosinase, has been used to develop tumor-targeted vaccines with mixed efficacy.

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Tyrosinase

Tyrosinase

Tyrosinase Related Products (245)

Antibodies (9)

Tyrosinase Related Products (245):