2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Thrombin

Thrombin

Thrombin

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Thrombin is a Na+-activated, serine protease which is activated by the enzymatic cleavage of two sites on prothrombin by activated Factor X. Thrombin exists in two allosteric forms, slow (S) and fast (F), target toward anticoagulant and procoagulant activities.

Thrombin is the main effector protease in primary hemostasis by activating platelets and plays a key role in secondary hemostasis. Besides its well-known functions in hemostasis, thrombin also plays a role in various non-hemostatic biological and pathophysiologic processes, predominantly mediated through activation of protease-activated receptors (PARs). PAR-1, PAR-3, and PAR-4 are cleaved by thrombin, whereas PAR-2 is cleaved by trypsin. Thrombin also plays a crucial role in the migration and metastasis of human cancer cells.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-167858
    LK-732
    		Inhibitor
    LK-732 is a thrombin inhibitor with anti-thrombotic activity.LK-732 has a dose-dependent inhibition of hypercoagulability in the model, with an IC50 of 1.3 mg/kg. LK-732 can be used in cardiovascular and cerebrovascular research.
    LK-732
  • HY-100245
    OM-189
    		Inhibitor
    OM-189 is a selective synthetic thrombin inhibitor.
    OM-189
  • HY-P4795
    Acetyl-Hirudin (55-65) sulfated
    		Inhibitor
    Acetyl-Hirudin (55-65) (sulfated) is a Acetyl-fragment of Hirudin. Hirudin is a thrombin inhibitor with blood anticoagulant property.
    Acetyl-Hirudin (55-65) sulfated
  • HY-149396
    FXIIa-IN-1
    		Inhibitor
    XIIa-IN-1-IN-3 (Compound 22) is a Factor XIIa inhibitor (Kiapp: 97.8 nM). XIIa-IN-1-IN-3 can be used for research of thrombosis.
    FXIIa-IN-1
  • HY-107966
    Heparin calcium (MW 15000-19000)
    		Inhibitor
    Heparin calcium (MW 15000-19000) is an anticoagulant which binds reversibly to antithrombin III (ATIII) to form a heparin-antithrombin III complex. The complex binds to and irreversibly inactivates thrombin and other activated clotting factors IX, X, XI, and XII and prevents the transformation of fibrinogen to fibrin.
    Heparin calcium (MW 15000-19000)
  • HY-77521R
    Dabigatran ethyl ester hydrochloride (Standard)
    		Inhibitor
    Dabigatran ethyl ester hydrochloride (Standard)
  • HY-N13960
    Bacithrocin D
    		Inhibitor
    Bacithrocin D (Thiolstatin D) inhibits multiple proteases and can prolong the clotting time. Bacithrocin D has IC50 values of 124, 9, 0.85, and 0.01 μM for thrombin, factor Xa, trypsin, and papain, respectively.
    Bacithrocin D
  • HY-117561
    DuP 714
    		Inhibitor
    DuP 714 is an oral active thrombin inhibitor with the IC50 values of 150 nM aganist thrombin-induced aggregation in washed human platelets. DuP 714 can be used for study of arterial thrombosi.
    DuP 714
  • HY-117798
    LY 806303
    		Inhibitor
    LY 806303 is a potent and selective inhibitor of human α-thrombin. LY 806303 specifically acylates Ser-205 within the catalytic triad of α-thrombin on the heavy chain and a key site involved in the enzymatic activity of thrombin. The mechanism of action of LY 806303 as an enzyme inhibitor is through the specific acylation of this catalytic serine residue.
    LY 806303
  • HY-B0375AR
    Argatroban monohydrate (Standard)
    		Inhibitor
    Argatroban (monohydrate) (Standard) is the analytical standard of Argatroban (monohydrate). This product is intended for research and analytical applications. Argatroban (monohydrate) (MD-805 (monohydrate)) is a direct, selective thrombin inhibitor.
    Argatroban monohydrate (Standard)
  • HY-136898
    PS-915 dihydrochloride
    PS-915 dihydrochloride is a peptide substrate used in a colorimetric assay for plasma antithrombin III (ATIII). PS-915 dihydrochloride is highly specific for thrombin. By enzyme hydrolysis, PS-915 dihydrochloride liberates 3-carboxy-4-hydroxyaniline (CHA), which turns blue in color due to the complex formation with added alkaline-pentacyanoammine ferroate.
    PS-915 dihydrochloride
  • HY-N13950
    Bacithrocin A
    		Inhibitor
    Bacithrocin A is a thrombin inhibitor that inhibits thrombin, factor Xa, trypsin and Papain with IC50s of 48 μM, 13 μM, 0.65 μM, and 0.02 μM, respectively.
    Bacithrocin A
  • HY-148826
    Rovunaptabin
    		Inhibitor
    Rovunaptabin (ARC 183) is a DNA aptamer, which is a single-stranded DNA molecule consisting of 15 deoxynucleotides that forms well-defined three-dimensional configuration, allowing it to bind to thrombin with high affinity and specificity.
    Rovunaptabin
  • HY-12605S
    SAR107375-d11 Tartrate
    		Inhibitor
    SAR107375-d11 (Tartrate) is deuterium labeled SAR107375. SAR107375 is a potent and orally active dual thrombin and factor Xa inhibitor, with Ki values of 1 nM and 8 nM for factor Xa and thrombin, respectively.
    SAR107375-d<sub>11</sub> Tartrate
  • HY-B0924R
    Anisindione (Standard)
    		Inhibitor
    Anisindione (Standard) is the analytical standard of Anisindione. This product is intended for research and analytical applications. Anisindione is a synthetic anticoagulant. It inhibits the formation of active procoagulant factors II, VII, IX, and X.
    Anisindione (Standard)
  • HY-19442
    Idrabiotaparinux
    Idrabiotaparinux, a derivative of Idraparinux (HY-19691), is a novel synthetic anticoagulant that links Idraparinux, a specific, indirect factor Xa inhibitor, to biotin.
    Idrabiotaparinux
  • HY-10274AR
    Dabigatran etexilate mesylate (Standard)
    		Inhibitor
    Dabigatran etexilate (mesylate) (Standard) is the analytical standard of Dabigatran etexilate (mesylate). This product is intended for research and analytical applications. Dabigatran etexilate mesylate (BIBR 1048MS) is an orally active proagent of Dabigatran (a direct inhibitor of thrombin). Dabigatran etexilate mesylate has anticoagulant effects and is used for the prophylaxis of venousthromboembolism and stroke due to atrial fibrillation.
    Dabigatran etexilate mesylate (Standard)
  • HY-N13957
    Bacithrocin C
    		Inhibitor
    Bacithrocin C is a thrombin inhibitor that inhibits thrombin, factor Xa, trypsin and Papain with IC50s of 80 μM, 15 μM, 1.3 μM, and 0.02 μM, respectively.
    Bacithrocin C
  • HY-19219A
    BMS-189664 hydrochloride
    		Inhibitor
    BMS-189664 hydrochloride is a potent, selective, and orally active reversible inhibitor of a-thrombin, with an IC50 of 0.046 μM. BMS-189664 hydrochloride can be used for arterial and venous thrombosis research.
    BMS-189664 hydrochloride
  • HY-118177
    Neutrophil elastase inhibitor 1
    		Inhibitor
    Neutrophil elastase inhibitor 1 (Compound 5b) is a competitive, pseudoirreversible inhibitor for neutrophil elastase with an IC50 of 7 nM.
    Neutrophil elastase inhibitor 1
Cat. No. Product Name / Synonyms Application Reactivity