2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Thrombin

Thrombin

Thrombin

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Thrombin is a Na+-activated, serine protease which is activated by the enzymatic cleavage of two sites on prothrombin by activated Factor X. Thrombin exists in two allosteric forms, slow (S) and fast (F), target toward anticoagulant and procoagulant activities.

Thrombin is the main effector protease in primary hemostasis by activating platelets and plays a key role in secondary hemostasis. Besides its well-known functions in hemostasis, thrombin also plays a role in various non-hemostatic biological and pathophysiologic processes, predominantly mediated through activation of protease-activated receptors (PARs). PAR-1, PAR-3, and PAR-4 are cleaved by thrombin, whereas PAR-2 is cleaved by trypsin. Thrombin also plays a crucial role in the migration and metastasis of human cancer cells.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-10275A
    Atecegatran TFA
    		Inhibitor
    Atecegatran TFA (AR-H067637 TFA) is an anticoagulant with selective direct thrombin inhibitory activity. Atecegatran TFA is commonly used to inhibit cardiovascular diseases. The biotransformation product of Atecegatran TFA, AR-H067637, is its active form and participates in the anticoagulation process.
    Atecegatran TFA
  • HY-P11048
    Thrombin-cleavable peptide
    		Ligand
    Thrombin-cleavable peptide is a type of peptide that can be recognized and cleaved by thrombin. After cleavage, Thrombin-cleavable peptide releases thrombolytic peptides to initiate thrombolysis. Thrombin-cleavable peptide can be used in the research of diseases such as ischemic stroke.
    Thrombin-cleavable peptide
  • HY-117745
    DS-1040
    		Inhibitor
    DS-1040 is an inhibitor of the activated thrombin-activatable fibrinolysis (TAFIa). DS-1040 can promote fibrinolysis through suppressing TAFIa activity. DS-1040 can be studied in thrombolytic disease research.
    DS-1040
  • HY-P4325
    Hirudin (55-65) sulfated
    		Inhibitor
    Hirudin (55-65) (sulfated) is a fragment of Hirudin with anticoagulant effects. Hirudin is a thrombin inhibitor with blood anticoagulant property.
    Hirudin (55-65) sulfated
  • HY-B0209R
    Metolazone (Standard)
    		Inhibitor
    Metolazone (Standard) is the analytical standard of Metolazone. This product is intended for research and analytical applications. Metolazone (SR-720-22) is primarily used to treat congestive heart failure and high blood pressure.
    Metolazone (Standard)
  • HY-B0375S1
    Argatroban-13C6 hydrochloride
    		Inhibitor
    Argatroban-13C6 hydrochloride is 13C labeled Argatroban (HY-B0375). Argatroban (MD-805) is a direct, selective thrombin inhibitor.
    Argatroban-<sup>13</sup>C<sub>6</sub> hydrochloride
  • HY-14878
    (2R)-Atecegatran
    		Inhibitor
    (2R)-Atecegatran ((2R)-AZD-0837; (Ph(3-Cl)(5-OCHF2)-(R)CH(OH)C(O)-Aze-Pab)) is a thrombin inhibitor. (2R)-Atecegatran can be used in research related to thromboembolic disorders.
    (2R)-Atecegatran
  • HY-122542
    PPACK
    		Inhibitor
    PPACK is potent, selective and irreversible thrombin inhibitor. PPACK can be used an alternative anticoagulant to lithium heparin (LiHep) for blood gas and whole-blood electrolyte analyses. PPACK is also a plasminogen activator (rt-PA) inhibitor. PPACK can inhibit the binding of rt-PA to plasma protease inhibitors.
    PPACK
  • HY-12605
    SAR107375
    		Inhibitor
    SAR107375 is a potent and orally active dual thrombin and factor Xa inhibitor, with Ki values of 1 nM and 8 nM for factor Xa and thrombin, respectively.
    SAR107375
  • HY-P10293
    NQEQVSP
    		Inhibitor
    NQEQVSP, a fibrin-binding protein-derived peptide (FBP), is a factor XIIIa substrate. NQEQVSP can be recognized by factor XIII and is enzymatically conjugated into fibrin during polymerization.
    NQEQVSP
  • HY-162646
    FXIIa-IN-5
    		Inhibitor
    FXIIa-IN-5 (Compound 4J) is an orally active, selective inhibitor for factor XIIa (FXIIa), with IC50 of 21 nM. FXIIa-IN-5 inhibits the intrinsic coagulation pathways, and exhibits anti-inflammatory and antithrombotic activity in Carrageenan (HY-125474)-induced mice thrombosis models. FXIIa-IN-5 exhibits moderate pharmacokinetic characteristics and slightly toxicity (at 100 mg/kg).
    FXIIa-IN-5
  • HY-P6027
    H-D-CHA-Ala-Arg-pNA
    H-D-CHA-Ala-Arg-pNA is a chromogenic substrate for the amidolytic assay.
    H-D-CHA-Ala-Arg-pNA
  • HY-151983
    Thrombin inhibitor 6
    		Inhibitor
    Thrombin inhibitor 6 is a potent thrombin inhibitor (IC50: 1 nM). Thrombin inhibitor 6 has the function as an anticoagulant.
    Thrombin inhibitor 6
  • HY-N16369
    1,2-Di-(9Z-hexadecenoyl)-sn-glycerol
    		Inhibitor
    1,2-Di-(9Z-hexadecenoyl)-sn-glycerol (Compound 2e) is a diacylglycerol derivative that can be isolated from the fungus Stereum Hirsutum. 1,2-Di-(9Z-hexadecenoyl)-sn-glycerol has potential thrombin-inhibiting activity and can be used in research related to antithrombotic drugs.
    1,2-Di-(9Z-hexadecenoyl)-sn-glycerol
  • HY-19674
    SSR182289
    		Inhibitor
    SSR182289 (SSR182289A free base) is a selective and potent orally active thrombin inhibitor. SSR182289 competitively and selectivity inhibits human thrombin (Ki=0.031 μM). SSR182289 demonstrates anticoagulant activity in vitro (thrombin time EC100=96 nM) and inhibits tissue factor-induced thrombin generation (IC50=0.15 μM) in human plasma. SSR182289 inhibits thrombin-induced aggregation of human platelets (IC50=32 nM), but has no effect on aggregation induced by other platelet agonists .
    SSR182289
  • HY-11090
    DPC423 free base
    		Inhibitor
    DPC423 free base is a selective and orally active factor Xa inhibitor with a Kis of 0.15 (human) and 0.3 (rabbit) nM. DPC423 free base exhibits Kis of 60, 61 and 6000 nM against human trypsin, plasma kallikrein and thrombin. DPC423 free base blocks the formation of prothrombinase complex, reduces thrombin production, inhibits fibrin formation and platelet activation. DPC423 free base has demonstrated antithrombotic effects in animal models, and when used in combination with Aspirin (HY-14654), it shows a strong synergistic effect. DPC423 free base can be used for the study of anticoagulation of arterial thrombosis.
    DPC423 free base
  • HY-15759
    Napsagatran
    		Inhibitor
    Napsagatran (Ro 46-6240) is a potent thrombin inhibitor. Napsagatran exhibits anticoagulant effects in vitro and in vivo. Napsagatran can be used in antithrombotic research[1][2].
    Napsagatran
  • HY-114603A
    Efegatran sulfate
    		Inhibitor
    Efegatran (LY 294468) sulfate is an inhibitor for thrombin, which inhibits aggregation of platelets, and exhibits anticoagulant and antithrombotic activities.
    Efegatran sulfate
  • HY-151146
    (1R,3S)-THCCA-Asn
    		Inhibitor
    (1R,3S)-THCCA-Asn (4j) is a selective thrombin inhibitor with the IC50 value in the range of 0.07 to 0.14 μM. ((1R,3S)-THCCA-Asn has antithrombotic activity.
    (1R,3S)-THCCA-Asn
  • HY-173207
    Antiplatelet agent 3
    		Inhibitor
    Antiplatelet agent 3 (Compound K-10) is a compound with anti-platelet aggregation activity. The IC50 values for platelet aggregation induced by ADP, AA and COL are 2.55, 3.22 and 2.09 mg/mL, respectively. Antiplatelet agent 3 is expected to be used in the research of cardiovascular diseases.
    Antiplatelet agent 3
Cat. No. Product Name / Synonyms Application Reactivity