2. Signaling Pathways
  3. Protein Tyrosine Kinase/RTK
  4. Src
  5. Blk Isoform
  6. Blk Inhibitor

Blk Inhibitor

Blk Inhibitors (3):

Cat. No. Product Name Effect Purity
  • HY-157442
    GLPG3312
    		Inhibitor 98.25%
    GLPG3312 (Compound 28) is an orally active SIK inhibitor with IC50 values of 2.0 nM, 0.7 nM and 0.6 nM for SIK1, SIK2 and SIK3, respectively. GLPG3312 exhibits anti-inflammatory and immunomodulatory activity in vitro on human primary myeloid cells and in vivo in mouse models. GLPG3312 has good oral bioavailability and can be used for research on inflammatory and immune diseases.
  • HY-118105
    RK-20448
    		Inhibitor 99.38%
    RK-20448 is an ATP-competitive inhibitor of Lck, Src, VEGFR2/KDR/Flk-1/VEGF2R and Tie-2 with IC50 values of 0.24, 1.19, 10.74 and 5.85 µM, respectively. RK-20448 also inhibits BLK, Csk, Fyn and Lyn with IC50 values of 0.37, 4.27, 2.03 and 0.43 µM, respectively. RK-20448 is the cis isomer of A-419259 (HY-15764).
  • HY-120622
    BMS-243117
    		Inhibitor
    BMS-243117 is a potent, and selective benzothiazole based p56Lck inhibitor with an IC50 of 4 nM. BMS-243117 inhibits anti-CD3/anti-CD28 induced PBL (human peripheral blood T-cells) proliferation with an IC50 of 1.1 μM. BMS-243117 binds in an extended conformation to the ATP-binding site of Lck.