2. Signaling Pathways
  3. Stem Cell/Wnt
  4. Smo

Smo

Smoothened

Smo

Related Products

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Smoothened (Smo), a class Frizzled G protein-coupled receptor (class F GPCR), transduces the Hedgehog (Hh) signal across the cell membrane. The Hh signaling pathway includes both canonical and noncanonical pathways. The canonical Hh pathway functions through major Hh molecules such as Hh ligands, PTCH, Smo, and GLI, whereas the noncanonical Hh pathway involves the activation of Smo or GLI through other pathways.

The Hh signaling cascade is initiated by the binding of the Hh protein ligand to its cellular membrane receptor, Patched (PTCH), which relieves PTCH-mediated repression of the seven-transmembrane (7TM) protein Smo. Activated Smo transduces the signal to the GLI family of transcription factors, which translocate to the nucleus to regulate numerous gene products involved in tissue patterning and cell differentiation.

Smo Related Products (72):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-148440
    RL-0070933
    		Modulator
    RL-0070933 is a potent smo cilial modulator with an EC50 value of 0.02 µM. RL-0070933 modulates the translocation and/or accumulation of smoothened to the primary cilia by hedgehog signaling pathway.
    RL-0070933
  • HY-12316R
    20(S)-Hydroxycholesterol (Standard)
    		Activator
    20(S)-Hydroxycholesterol (Standard) is the analytical standard of 20(S)-Hydroxycholesterol. This product is intended for research and analytical applications. 20(S)-hydroxyCholesterol (20α-Hydroxycholesterol) is an allosteric activator of the oncoprotein smoothened (Smo) that activates the hedgehog (Hh) signaling pathway with an EC50 of 3 μM in a gene transcription reporter assay using NIH3T3 cells.
    20(S)-Hydroxycholesterol (Standard)
  • HY-162273
    Antibacterial agent 189
    Antibacterial agent 189 (compound 3a) is a potent antimicrobial agent. Antibacterial agent 189 offers high binding energy against the target OMPA/exo-1,3-beta-glucanase proteins. Antibacterial agent 189 exhibits the potent antimicrobial activities against E. coli, P. aeruginosa, S. aureus, B. subtilis, C. Albicans and A. flavus. Antibacterial agent 189 shows high binding energy against target SMO and SUFU/GLI-1 proteins.
    Antibacterial agent 189
  • HY-B0877R
    Halcinonide (Standard)
    		Agonist
    Halcinonide (Standard) is the analytical standard of Halcinonide. This product is intended for research and analytical applications. Halcinonide (SQ-18566) is a high potency corticosteroid used topically in the treatment of certain skin conditions.
    Halcinonide (Standard)
  • HY-16582AR
    Sonidegib (Standard)
    		Antagonist
    Sonidegib (Standard) is the analytical standard of Sonidegib. This product is intended for research and analytical applications. Sonidegib (Erismodegib) is a potent and selective Smo antagonist with IC50 of 1.3 nM and 2.5 nM for mouse and human Smo in binding assay, respectively.
    Sonidegib (Standard)
  • HY-16391R
    Glasdegib (Standard)
    		Inhibitor
    Glasdegib (Standard) is the analytical standard of Glasdegib. This product is intended for research and analytical applications. Glasdegib (PF-04449913) is a potent and orally bioavailable smoothened inhibitor. Glasdegib (PF-04449913) binds to human SMO (amino acids 181-787) with an IC50 of 4 nM.
    Glasdegib (Standard)
  • HY-123752
    MS-0022
    		Antagonist
    MS-0022 is a Smoothened (SMO) antagonist. MS-0022 can inhibit the Hedgehog (Hh) signaling pathway. MS-0022 can be used in anti-tumor research.
    MS-0022
  • HY-117903A
    MRT-92
    		Antagonist
    MRT-92 is a Smoothened (Smo) antagonist (Ki=0.7 nM) with anticancer activity. MRT-92 inhibits Hedgehog signaling pathway and rodent cerebellar granule cell proliferation by blocking overlapping binding sites in the transmembrane domain of the Smoothened receptor (IC50=0.4 nM). MRT-92 can be used in the study of cerebellar glioma.
    MRT-92
  • HY-150564
    SMO-IN-2
    		Inhibitor 98.12%
    SMO-IN-2 is a potent smoothened (SMO) inhibitor with an IC50 value of 123.4 nM for hedgehog (Hh) signaling pathway. SMO-IN-2 has antiproliferative activity against human medulloblastoma cell line Daoy. Anticancer activity.
    SMO-IN-2
  • HY-133974
    7-keto-25-Hydroxycholesterol
    		Activator
    7-keto-25-Hydroxycholesterol (7-keto-25-OHC), a oxysterol, is a Smoothened (Smo) activator. 7-keto-25-Hydroxycholesterol binds to the extracellular cysteine-rich domain (CRD) of Smo.
    7-keto-25-Hydroxycholesterol
  • HY-16587A
    Saridegib hydrochloride
    		Inhibitor
    Saridegib hydrochloride is a potent and specific inhibitor of Smoothened (Smo), a key signaling transmembrane protein in the Hedgehog (Hh) pathway.
    Saridegib hydrochloride
  • HY-B0603R
    Fluticasone (Standard)
    		Agonist
    Fluticasone (Standard) is the analytical standard of Fluticasone. This product is intended for research and analytical applications. Fluticasone is an inhaled corticosteroid used for respiratory research. Fluticasone is a Smo agonist with an IC50 value of 99 nM. Fluticasone activates Hedgehog signaling and promotes the proliferation of primary neuronal stem or precursor cells.
    Fluticasone (Standard)