2. Signaling Pathways
  3. Cell Cycle/DNA Damage
    Epigenetics
  4. Sirtuin

Sirtuin

Sirtuin

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Sirtuin (Sir2 proteins) are a class of proteins that possess either mono-ADP-ribosyltransferase, or deacylase activity, including deacetylase, desuccinylase, demalonylase, demyristoylase and depalmitoylase activity. Sirtuins regulate important biological pathways in bacteria, archaeaand eukaryotes. Sirtuins have been implicated in influencing a wide range of cellular processes like aging, transcription, apoptosis, inflammation and stress resistance, as well as energy efficiency and alertness during low-calorie situations. Sirtuins can also control circadian clocks and mitochondrial biogenesis.

Sirtuin Isoform Specific Products:

Sirtuin Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-117006
    E1231
    		Activator 98.55%
    E1231 is an orally active activator of Sirtuin 1 (SIRT1) (EC50=0.83 μM), to modulate cholesterol and lipid metabolism. E1231 interactes with SIRT1 (KD=9.61 μM) and deacetylated liver X receptor-alpha (LXRα), and increases ATP-binding cassette transporter A1 (ABCA1) expression. E1231 also reduces atherosclerotic plaque development in ApoE-/- mice model. E1231 can be used for research in cholesterol and lipid disorder-related diseases.
    E1231
  • HY-15510B
    Tenovin-6 Hydrochloride
    		Inhibitor 98.88%
    Tenovin-6 Hydrochloride, an analog of Tenovin-1 (HY-13423), is an activator of p53 transcriptional activity. Tenovin-6 Hydrochloride inhibits the protein deacetylase activities of purified human SIRT1, SIRT2, and SIRT3 with IC50s of 21 μM, 10 μM, and 67 μM, respectively. Tenovin-6 Hydrochloride also inhibits dihydroorotate dehydrogenase (DHODH).
    Tenovin-6 Hydrochloride
  • HY-107245
    Segetalin B
    		Activator 99.51%
    Segetalin B, an orally active cyclopentapeptide found in Vaccaria segetalis, possesses estrogen-like activity. Segetalin B promotes mineralization of ovariectomized rat-derived bone marrow mesenchymal stem cells (BMSCs) in vitro and increases the level of osteocalcin, BMP-2, ALP, and SIRT1 activity. Segetalin B is promising for research of post-menopausal osteoporosis (PMOP).
    Segetalin B
  • HY-16561S
    Resveratrol-d4
    		Activator 99.36%
    Resveratrol-d4 is the deuterium labeled Resveratrol. Resveratrol (trans-Resveratrol; SRT501), a natural polyphenolic phytoalexin that possesses anti-oxidant, anti-inflammatory, cardioprotective, and anti-cancer properties. Resveratrol (SRT 501) has a wide spectrum of targets including mTOR, JAK, β-amyloid, Adenylyl cyclase, IKKβ, DNA polymerase. Resveratrol also is a specific SIRT1 activator. Resveratrol is a potent pregnane X receptor (PXR) inhibitor. Resveratrol is an Nrf2 activator, ameliorates aging-related progressive renal injury in mice model. Resveratrol increases production of NO in endothelial cells.
    Resveratrol-d<sub>4</sub>
  • HY-P5247
    Palmitoyl tetrapeptide-20
    		Activator 99.67%
    Palmitoyl tetrapeptide-20 (PTP20) is a biomimetic peptide agonist of α-MSH. Palmitoyl tetrapeptide-20 promotes hair pigmentation and delays hair graying by activating the MC1-R pathway (AC50: 0.16 nM), enhancing catalase activity to reduce H2O2 accumulation, and upregulating SIRT1 activity. Palmitoyl tetrapeptide-20 can be used in research on preventing hair loss and improving hair graying.
    Palmitoyl tetrapeptide-20
  • HY-156757
    MDL-811
    		Activator 99.68%
    MDL-811 is a selective allosteric activator of SIRT6 with an EC50 of 5.7 μM. MDL-811 possesses anti-inflammatory, antitumor, and neuroprotective activities. MDL-811 can be used for the research of diseases such as colorectal cancer and ischemic stroke.
    MDL-811
  • HY-108986
    JFD00244
    		Inhibitor 99.40%
    JFD00244 is a sirtuin 2 (SIRT2) inhibitor, with anti-tumor effect. JFD00244 is also a Nsp-16 inhibitor against SARS-CoV-2.
    JFD00244
  • HY-123194
    SIRT2/6-IN-1
    		Inhibitor 99.79%
    SIRT2/6-IN-1 (Compound 5) is a SIRT6/SIRT2 inhibitor, with IC50s of 106 μM and 114 μM. SIRT2/6-IN-1 increases H3K9 acetylation, increases glucose uptake and reduces TNF-α secretion in cells.
    SIRT2/6-IN-1
  • HY-156781
    Sirtuin-1 inhibitor 1
    		Inhibitor 98.09%
    Sirtuin-1 inhibitor 1 (Compound 8) is an inhibitor of Sirtuin-1 that plays important roles in obesity-induced diabetes and aging-related diseases.
    Sirtuin-1 inhibitor 1
  • HY-RS12937
    SIRT1 Human Pre-designed siRNA Set A
    		Inhibitor

    SIRT1 Human Pre-designed siRNA Set A contains three designed siRNAs for SIRT1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
    SIRT1 Human Pre-designed siRNA Set A
    SIRT1 Human Pre-designed siRNA Set A
  • HY-101465
    AK-1
    		Inhibitor 99.97%
    AK-1 is a potent, specific and cell-permeable SIRT2 inhibitor, with an IC50 of 12.5 μM.
    AK-1
  • HY-146689
    SIRT1-IN-2
    		Inhibitor 98.86%
    SIRT1-IN-2 (compound 3h) is a potent and selective SIRT1 (silent information regulator 1) inhibitor, with an IC50 of 1.6 μM.
    SIRT1-IN-2
  • HY-N6675
    Gardenia yellow
    		Activator
    Gardenia yellow is an active member of crocin, increases mRNA expression of SIRT3, and acts as an orally active antidepressant agent.
    Gardenia yellow
  • HY-16615
    SIRT-IN-1
    		Inhibitor 98.14%
    SIRT-IN-1 is a potent inhibitor of SIRT1/2/3, with IC50s of 15, 10, 33 nM, respectively.
    SIRT-IN-1
  • HY-163987
    SIRT3 activator 2
    		Activator 98.94%
    SIRT3 activator 2 (compound 2a) is a SIRT3 activator. SIRT3 activator 2 improved the thermal stability of SIRT3 in SH-SY5Y cells, indicating that it can directly bind to SIRT3, has SIRT3 dependency in SH-SY5Y to clear α-Syn. SIRT3 activator 2 improves motor function in Parkinson mice, preventing Parkinson (DA) neuron loss in the substantia nigra in a dose-dependent manner.
    SIRT3 activator 2
  • HY-15452A
    (S)-Selisistat
    		Inhibitor 99.39%
    (S)-Selisistat ((S)-EX-527) is a potent and selective SIRT1 inhibitor, with an IC50 of 98 nM.
    (S)-Selisistat
  • HY-107660
    SIRT2-IN-8
    		Inhibitor 99.32%
    SIRT2-IN-8 is a potent SIRT2 inhibitor. SIRT2-IN-8 can be used for Huntington’s and Parkinson’s diseases research.
    SIRT2-IN-8
  • HY-E70008
    Lumbokinase
    		Activator
    Lumbokinase attenuates myocardial ischemia-reperfusion (I-R) injury through the activation of Sirt1 signaling, and thus enhances autophagic flux and reduces I-R-induced oxidative damage, inflammation and apoptosis.
    Lumbokinase
  • HY-146690
    SIRT1-IN-3
    		Inhibitor 99.12%
    SIRT1-IN-3 (compound 3j) is a potent and selective SIRT1 inhibitor, with an IC50 of 4.2 μM.
    SIRT1-IN-3
  • HY-19634
    YK-3-237
    		Activator 99.54%
    YK-3-237, a SIRT1 activator, targets mutant p53. YK-3-237 inhibits the proliferation of triple-negative breast cancer cells.
    YK-3-237
Cat. No. Product Name / Synonyms Application Reactivity
Sirtuin Isoform Comparison

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