2. Signaling Pathways
  3. Immunology/Inflammation
  4. STING

STING

Stimulator of Interferon Genes; TMEM173; MITA; ERIS; MPYS

STING

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Stimulator of interferon genes (STING) is an integral ER-membrane protein that can be activated by 2'3'-cGAMP synthesized by cyclic guanosine monophosphate-adenosine monophosphate synthase (cGAS) upon binding of double-stranded DNA. It activates interferon (IFN) and inflammatory cytokine responses to defend against infection by microorganisms.

STING is a key cytosolic receptor for small nucleotides and plays a key role in anticancer and antiviral immunity. STING signaling pathway is also a critical link between innate and adaptive immunity, and induces anti-tumor immune responses. STING agonists, such as endogenous cyclic dinucleotide (CDN) cyclic GMP-AMP (cGAMP), have been used in diverse research for immunogenic tumor clearance, antiviral treatments and vaccine adjuvants.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-148420
    CDN-A
    		Activator
    CDN-A is a cyclic di-nucleotide, it can be used to synthesis antibody-drug conjugate (ADC). Cyclic di-nucleotides are potent stimulators of innate and adaptive immune responses. In humans, cyclic di-nucleotide, which are either produced endogenously in response to foreign DNA or by invading bacterial pathogens, trigger the innate immune system by activating the expression of interferon genes.
    CDN-A
  • HY-144328
    STING agonist-10
    		Activator
    STING agonist-10 (Compound 91) is a potent small molecule cyclic urea activator of STING with the EC50 of 2600 nM. Activation of STING is a highly promising approach in immunotherapy.
    STING agonist-10
  • HY-170949
    STING-IN-11
    		Inhibitor
    STING-IN-11 (Compound 42) is an orally active STING inhibitor with an IC50 of 37.8 nM. STING-IN-11 can block the palmitoylation of the STING protein and STING downstream signaling, and inhibit STING-mediated inflammation. STING-IN-11 has good in vivo safety and can be used for the research of STING-related inflammatory and autoimmune diseases.
    STING-IN-11
  • HY-163749
    STING-IN-8
    		Inhibitor
    STING-IN-8 (Compound 15b) emerges as a potent stimulator of interferon gene (STING) inhibitor with an IC50 value of 0.121 μM in human and an IC50 value of 0.033 μM in mouse. STING-IN-8 inhibits MSA-2 (HY-136927) or 2’, 3’ -cGAMP (HY-100564)-stimulated STING signaling and suppresses immune-inflammatory cytokine levels in both human and murine cells. STING-IN-8 is promising for research in the field of STING-associated inflammatory and autoimmune diseases.
    STING-IN-8
  • HY-151264
    BSP16
    		Inhibitor 98.3%
    BSP16 is a potent, orally active stimulator of interferon genes (STING) agonist. BSP16 can selectively stimulate the STING pathway. BSP16 can be used for the research of cancer.
    BSP16
  • HY-110382S
    13C20,15N10-Cyclic di-GMP sodium
    		Activator
    13C20,15N10-Cyclic di-GMP (13C20,15N10-c-di-GMP) is 13C and 15N labeled Cyclic-di-GMP (disodium). Cyclic-di-GMP disodium is a STING agonist and a bacterial second messenger that coordinates different aspects of bacterial growth and behavior, including motility, virulence, biofilm formation, and cell cycle progression. Cyclic-di-GMP disodium has anti-cancer cell proliferation activity and also induces elevated CD4 receptor expression and cell cycle arrest. Cyclic-di-GMP disodium can be used in cancer research.
    <sup>13</sup>C<sub>20</sub>,<sup>15</sup>N<sub>10</sub>-Cyclic di-GMP sodium
  • HY-137709
    2'2'-cGAMP
    		Activator
    2'2'-cGAMP, a synthetic CDN, binds STING in the immune response, inducing IFN-β. 2'2'-cGAMP binds weaker binding to STING than 2'3'-cGAMP (HY-100564) but stronger than other CDNs.
    2'2'-cGAMP
  • HY-148546
    STING agonist-21
    		Agonist
    STING agonist-21 (compound 1) is a STING agonist, with an EC50 of 592.8 nM. STING agonist-21 can be used for cancer research.
    STING agonist-21
  • HY-10964R
    Vadimezan (Standard)
    		Agonist
    Vadimezan (Standard) (DMXAA (Standard)) is the analytical standard of Vadimezan (HY-10964). This product is intended for research and analytical applications. Vadimezan (DMXAA; ASA-404), the tumor vascular disrupting agent (tumor-VDA), is a murine agonist of the stimulator of interferon genes (STING) and also a potent inducer of type I IFNs and other cytokines. Vadimezan is unable to activate human STING. Vadimezan has anti-influenza virus H1N1-PR8 activities.
    Vadimezan (Standard)
  • HY-139586B
    Ulevostinag (isomer 2)
    		Agonist
    Ulevostinag isomer 2 (MK-1454 isomer 2) is the isomer of Ulevostinag. Ulevostinag is a STING agonist.
    Ulevostinag (isomer 2)
  • HY-158711
    STING agonist-38
    		Agonist
    STING agonist-38 (compound 58) is a potent agonist of STING, with the EC50 of 0.05 μM in THP1 cells. STING agonist-38 has certain oral bioactivity.
    STING agonist-38
  • HY-149724
    Anti-inflammatory agent 65
    		Inhibitor
    Anti-inflammatory agent 65 (compound 29) is a Hederagonic acid derivative with potent anti-inflammatory activity. Anti-inflammatory agent 65 inhibits nitric oxide (NO) release. Anti-inflammatory agent 65 inhibits the nuclear translocation of IRF3 and p65, and disrupts the STING/IRF3/NF-κB signaling pathway, thereby attenuating the inflammatory response.
    Anti-inflammatory agent 65
  • HY-168803
    BDW-OH
    		Agonist
    BDW-OH is an active metabolite of BDW568 (HY-162465 ). BDW568 is a STING agonist that can selectively activate the human STINGA230 allele.
    BDW-OH
  • HY-164919
    Calotatug ginistinag
    		Agonist
    Calotatug ginistinag (XMT-2056) is an antibody-drug conjugate targeting HER2, with an effective payload connected via a linker (LP, HY-148067) to a STING agonist (STING agonist-20, HY-148068), and has potential immune activation and anticancer activity.
    Calotatug ginistinag
  • HY-N15159
    Cladophorol A
    		Inhibitor
    Cladophorol A is a cGAS inhibitor that binds to the conserved adenosine nucleobase binding site of cGAS, thereby blocking its activity. At non-cytotoxic concentrations, Cladophorol A effectively inhibits the overactivation of the cGAS-STING pathway with an IC50 of 370 nM. Cladophorol A holds potential for research on inflammatory diseases related to the overactivation of the cGAS-STING pathway.
    Cladophorol A
  • HY-168384
    M04
    		Agonist
    M04 is an agonist of STING. It induces the expression of the IFN reporter gene in HEK293T cells expressing wild-type human STING, but does not induce this expression in HEK293T cells expressing the R71H-G230A-R293Q (HAQ) STING variant or in mouse RAW 264.7 cells, indicating that its activity is dependent on allelic and species variations. M04 induces the production of TNF-α, IL-10, IL-1β, and IL-12p70 in human peripheral blood mononuclear cells (PBMCs). At a concentration of 50 µM, M04 stimulates dendritic cells isolated from PBMCs to express the MHC class II cell surface receptor HLA-DR and co-stimulatory molecules CD40, CD80, and CD86, and also enhances their ability to activate T cells in an ex vivo assay. M04 can be used in research on inflammatory immune diseases.
    M04
  • HY-163643
    STING modulator-7
    		Modulator
    STING modulator-7 (compound 132) is a modulator of STING,.
    STING modulator-7
  • HY-113469AR
    Cyclic GMP sodium (Standard)
    		Activator
    Cyclic GMP (sodium) (Standard) is the analytical standard of Cyclic GMP (sodium). This product is intended for research and analytical applications. Cyclic GMP (cGAMP) sodium is an endogenous second messenger that triggers interferon production in response to cytoplasmic DNA. Cyclic GMP sodium can activate the stimulator of interferon genes (STING), activating the signaling cascade that leads to the production of type I interferons and other immune mediators. Cyclic-GMP-AMP, a conjugate of cyclic GMP and AMP, can induce IRF3 phosphorylation and nuclear translocation, enhancing antiviral immune responses. Cyclic GMP sodium may also activate PDE to degrade cAMP, inhibit myocardial calcium current ICa, and regulate myocardial contractility. The derivative of Cyclic GMP sodium, 8-Br-cGMP, has antiplatelet activity, and Cyclic GMP sodium can be used in the study of antiviral immunity and cardiovascular diseases.
    Cyclic GMP sodium (Standard)
  • HY-139586C
    Ulevostinag (isomer 3)
    		Agonist
    Ulevostinag (isomer 3) (example 246) is a potent cyclic dinucleotide agonist stimulator of interferon genes (STING). Ulevostinag (isomer 3) plays an important role in anti-tumor research.
    Ulevostinag (isomer 3)
  • HY-100941R
    CCCP (Standard)
    		Inhibitor
    CCCP (Standard) is the analytical standard of CCCP. This product is intended for research and analytical applications. CCCP is an oxidative phosphorylation (OXPHOS) uncoupler. CCCP induces activation of PINK1 leading to Parkin Ser65 phosphorylation.
    CCCP (Standard)
Cat. No. Product Name / Synonyms Application Reactivity