2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Phosphatase

Phosphatase

Phosphatase

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Phosphatases are enzyme that remove a phosphate group from a protein. Protein tyrosine phosphatases (PTPs) comprise a diverse family of transmembrane and cytoplasmic enzymes. PTPs play an important role in regulating the proliferative activity of cells and the integrity of cell-cell and cell-matrix contacts. Protein tyrosine phosphatase 1B (PTP1B) is a non-receptor PTP frequently associated with the endoplasmic reticulum and vesicles subjacent to the plasma membrane. PTP1B as a key negative regulator of leptin receptor pathways has been an attractive therapeutic target for the treatment of type 2 diabetes mellitus and obesity. Four major serine/threonine-specific protein phosphatase catalytic subunits are present in the cytoplasm of animal cells. Three of these enzymes, PP1, PP2A, and PP2B, are members of the same gene family, while PP2C appears to be distinct.The alkaline phosphatases comprise a heterogeneous group of enzymes that are widely distributed in mammalian cells. Acid phosphatase enzymes catalyze the hydrolysis of phosphate monoesters following the general equation.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-10704
    PTP1B-IN-1
    		Inhibitor 99.65%
    PTP1B-IN-1 (Compound 7a) is a small molecule inhibitor of PTP1B with an IC50 value of 1.6 mM. It is often used as the mother core for derivatives of analogues.
    PTP1B-IN-1
  • HY-141800
    MurA-IN-1
    		Inhibitor 99.32%
    MurA-IN-1 (compound 1a) is a PTPRR inhibitor, with IC50 values of 0.23 μM, 0.8 μM, 0.75 μM and 0.09 μM for PTP1B, PTPN5, PTPN7 and PTPRR, respectively. (A family of human MAPK-specific protein tyrosine phosphatases)
    MurA-IN-1
  • HY-19779
    JTT 551
    		Inhibitor 99.65%
    JTT 551 is selective a protein tyrosine phosphatase 1B (PTP1B) inhibitor, with Kis of 0.22 μM and 9.3 μM for PTP1B and TCPTP (T-cell protein tyrosine phosphatase), respectively; JTT 551 can be used in the research of type 2 diabetes mellitus.
    JTT 551
  • HY-113976A
    Endothall
    		Antagonist
    Endothall (Endothal) is a protein phosphatase 2A (PP2A) inhibitor with IC50s of 90 nM and 5 µM for PP2A and PP1, respectively. Endothall can be used as an herbicide. Endothall also is useful in cancer chemotherapy.
    Endothall
  • HY-N1941
    Isosinensetin
    		Inhibitor 99.90%
    Isosinensetin is a flavonoid compound and an inhibitor of HIV-1 protease and PTP1B (IC50: 2.61 µM; Ki: 0.92 µM). Isosinensetin inhibits P-glycoprotein (P-gp) in MDR1-MDCKII cells. Isosinensetin has multiple activities such as anti-tumor, anti-viral, anti-inflammatory, and antioxidant effects. Isosinensetin can be used in the research of various diseases including cancer, inflammation, osteoporosis, diabetes, etc.
    Isosinensetin
  • HY-12833
    AMZ30
    		Inhibitor 99.76%
    AMZ30 is a highly potent inhibitor of phosphatase PME-1 (IC50=600 nM) and selectively reduces demethylated PP2A in cells.
    AMZ30
  • HY-101964
    SPI-112
    		Inhibitor 98.01%
    SPI-112 is a potent, selective and competitive SHP2 (PTPN11) inhibitor with IC50s of 1 μM, 18.3 μM and 14.5 μM for SHP2, protein tyrosine phosphatase (PTP) and PTP1B, respectively.
    SPI-112
  • HY-132578
    M5N36
    		Inhibitor 98.05%
    M5N36 is a potent and selective Cdc25C inhibitor with IC50 values of 0.15, 0.19, 0.06 µM for Cdc25A, Cdc25B, Cdc25C, respectively. M5N36 shows anti-proliferative activity and increases the expression of p-CDK1 and p-CDK2.
    M5N36
  • HY-N7269
    Luteolin 7-diglucuronide
    		Inhibitor 99.26%
    Luteolin 7-diglucuronide is the major flavonoid isolated from Aloysia triphylla and Verbena officinalis.
    Luteolin 7-diglucuronide
  • HY-W013478
    PTP inhibitor 1
    		Inhibitor 98.92%
    PTP inhibitor 1 is a protein tyrosine phosphatase (PTP) inhibitor, with anti-angiogenic effect.
    PTP inhibitor 1
  • HY-163828
    PPA24
    		Activator 98.09%
    PPA24 is a PP2A activator with a KD of 8.465 μM for PP2ACα). PPA24 induces cancer cell death via apoptosis. PP2ACα induces ROS generation and decrease the level of c-Myc expression. PPA24 can be used to study colorectal cancer (CRC), Folinic acid (HY-17556), 5-Fluorouracil (HY-90006), and Oxaliplatin (HY-17371) (FOLFOX)-resistant CRC, and melanoma cancer.
    PPA24
  • HY-159521
    HN252
    		Inhibitor 98.54%
    HN252 is a potent PPM1B inhibitor (Ki= 0.52 µM).
    HN252
  • HY-12312
    TCS 401
    		Inhibitor ≥98.0%
    TCS 401 is a selective inhibitor of protein tyrosine phosphatase 1B (PTP1B).
    TCS 401
  • HY-W002116
    Methyl syringate
    		Inhibitor 99.96%
    Methyl syringate is a selective TRPA1 agonist. Methyl syringate regulates food intake and gastric emptying through a TRPA1-mediated pathway. Methyl syringate is an efficient phenolic mediator for bacterial and fungal laccases. Methyl syringate is a chemical marker of Asphodel monofloral honey. Methyl syringate contributes to the antibacterial activity of honey. Methyl syringate inhibits aflatoxin production. Methyl syringate can contribute to weight suppression. Methyl syringate can be studies for cancer prevention (e.g. lung cancer), suppression of hypoxia-induced inflammatory response and tumorigenesis.
    Methyl syringate
  • HY-131901
    Phenylarsine oxide
    		Inhibitor 99.32%
    Phenylarsine oxide (PAO), an inhibitor of endocytosis, inhibits PTPε with an IC50 of 18 μM. Phenylarsine oxide (PAO) inhibits oxygen consumption and decreases cellular ATP content overlap with those used to inhibit protein internalization.
    Phenylarsine oxide
  • HY-136268
    AQX-435
    		Activator 99.15%
    AQX-435 is a potent SHIP1 phosphatase activator. AQX-435 reduces PI3K activation downstream of the B-cell receptor (BCR) and induces apoptosis of malignant B cells, and reduces lymphoma growth.
    AQX-435
  • HY-101510
    F1063-0967
    		Inhibitor 99.30%
    F1063-0967 is a Dual-specificity phosphatase 26 (DUSP26) inhibitor with an IC50 of 11.62 μM.
    F1063-0967
  • HY-111489B
    LMPTP inhibitor 1 dihydrochloride
    		Inhibitor 99.83%
    LMPTP INHIBITOR 1 (dihydrochloride) is a selective inhibitor of low molecular weight protein tyrosine phosphatase (LMPTP), with an IC50 of 0.8 μM LMPTP-A.
    LMPTP inhibitor 1 dihydrochloride
  • HY-155374
    PP5-IN-1
    		Inhibitor 99.20%
    PP5-IN-1 (Compound P053) is a competitive inhibitor of Serine/threonine protein phosphatase-5 (PP5) that binds to its catalytic domain and causes apoptosis in renal cancer.
    PP5-IN-1
  • HY-N5114
    Isovitexin 2''-O-arabinoside
    		Activator 99.49%
    Isovitexin 2''-O-arabinoside is a flavonoid in plantlets of Avena sativa L..
    Isovitexin 2''-O-arabinoside
Cat. No. Product Name / Synonyms Species Source
Cat. No. Product Name / Synonyms Application Reactivity