2. Signaling Pathways
  3. PI3K/Akt/mTOR
  4. PTEN
  5. PTEN Agonist

PTEN Agonist

PTEN Agonist (1):

Cat. No. Product Name Effect Purity
  • HY-144707
    AK-778-XXMU
    		Agonist 99.96%
    AK-778-XXMU is a potent DNA binding inhibitor 2 (ID2) antagonist with a KD of 129 nM. AK-778-XXMU can inhibit cell migration and invasion of glioma cell lines, induce apoptosis, and exhibits significant cancer-suppressing potency. AK-778-XXMU inhibits the ID2-KDR signaling axis, thereby down-regulating the downstream angiogenic factors (VEGFA) and invasion-related proteins (MMP2/9), and up-regulating the tumor suppressor factor (PTEN). AK-778-XXMU can be used for the study of glioma.