2. Signaling Pathways
  3. PROTAC
  4. PROTAC Linkers

PROTAC Linkers

PROTAC Linkers

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PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.

The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.

PROTAC Linkers Isoform Specific Products:

PROTAC Linkers Isoform Comparison
Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-115392
    Ms-PEG12-m 1059604-93-1
    Ms-PEG12-m is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Ms-PEG12-m
  • HY-141315
    m-PEG6-C6-phosphonic acid ethyl ester 2028281-88-9
    m-PEG6-C6-phosphonic acid ethyl ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    m-PEG6-C6-phosphonic acid ethyl ester
  • HY-132016
    Benzyl-PEG8-NHS ester
    Benzyl-PEG8-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Benzyl-PEG8-NHS ester
  • HY-141404
    m-PEG4-CH2-methyl ester 1920109-55-2
    m-PEG4-CH2-methyl ester is a PEG- and Alkyl/ester-based PROTAC linker can be used in the synthesis of PROTACs.
    m-PEG4-CH2-methyl ester
  • HY-133468
    Methyltetrazine-PEG6-maleimide
    Methyltetrazine-PEG6-maleimide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Methyltetrazine-PEG6-maleimide is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
    Methyltetrazine-PEG6-maleimide
  • HY-140378
    t-Boc-Aminooxy-PEG8-MS
    t-Boc-Aminooxy-PEG8-MS is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    t-Boc-Aminooxy-PEG8-MS
  • HY-140851
    Azido-PEG1-methyl ester 1835759-80-2
    Azido-PEG1-methyl ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG1-methyl ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG1-methyl ester
  • HY-140159
    Methylamino-PEG5-azide 2055046-24-5
    Methylamino-PEG5-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Methylamino-PEG5-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Methylamino-PEG5-azide
  • HY-138377
    Azido-PEG8-C-Boc 1984776-39-7
    Azido-PEG8-C-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG8-C-Boc is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG8-C-Boc
  • HY-126916
    Tetrahydropyranyldiethyleneglycol 2163-11-3
    Tetrahydropyranyldiethyleneglycol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Tetrahydropyranyldiethyleneglycol
  • HY-140016
    Bis-(m-PEG4)-amidohexanoic acid 2353409-74-0
    Bis-(m-PEG4)-amidohexanoic acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Bis-(m-PEG4)-amidohexanoic acid
  • HY-140870
    N-(Azido-PEG4)-N-bis(PEG4-t-butyl ester) 2093152-79-3
    N-(Azido-PEG4)-N-bis(PEG4-t-butyl ester) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. N-(Azido-PEG4)-N-bis(PEG4-t-butyl ester) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    N-(Azido-PEG4)-N-bis(PEG4-t-butyl ester)
  • HY-W096160
    Bis-acrylate-PEG5 59256-52-9
    Bis-acrylate-PEG5 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Bis-acrylate-PEG5
  • HY-141092
    Pyrene-PEG2-azide 2135330-58-2
    Pyrene-PEG2-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Pyrene-PEG2-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Pyrene-PEG2-azide
  • HY-141085
    Carboxyfluorescein-PEG12-NHS 2246595-66-2
    Carboxyfluorescein-PEG12-NHS is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Carboxyfluorescein-PEG12-NHS
  • HY-164951
    C1-BCEA-Acm 2223042-67-7
    C1-BCEA-Acm is a linker, that can be used for synthesis of polyubiquitin chains and ubiquitin-modified substrates.
    C1-BCEA-Acm
  • HY-140168
    Carboxy-PEG4-sulfonic acid 1817735-25-3
    Carboxy-PEG4-sulfonic acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Carboxy-PEG4-sulfonic acid
  • HY-140714
    HO-PEG-amine (MW 2000)
    HO-PEG-amine (MW 2000) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    HO-PEG-amine (MW 2000)
  • HY-140414
    t-Boc-Aminooxy-PEG12-acid
    t-Boc-Aminooxy-PEG12-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    t-Boc-Aminooxy-PEG12-acid
  • HY-W096158
    Ph-PEG3 7204-16-2
    Ph-PEG3 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Ph-PEG3
PROTAC Linkers Isoform Comparison

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