2. Signaling Pathways
  3. PI3K/Akt/mTOR
  4. PI3K
  5. PI3Kα Isoform
  6. PI3Kα Activator

PI3Kα Activator

PI3Kα Activator (1):

Cat. No. Product Name Effect Purity
  • HY-128574
    D927
    		Activator 99.46%
    D927 (DS11252927) is an orally active glucose transporter type 4 (GLUT4) translocation activator with an EC50 of 0.14 μM. D927 enhances the binding affinity of PI3Kα catalytic subunit p110α to canonical RAS proteins (KRAS4A, KRAS4B) and RRAS, RRAS2, MRAS. D927 activates the PI3Kα-AKT pathway (increasing phosphorylation of AKT, p70S6 kinase) without affecting the RAF-ERK1/2 pathway. D927 improves hyperglycemia in type 1 and type 2 diabetes mice model. D927 can be used for the study of glucose homeostasis disorders and diabetes.