2. Signaling Pathways
  3. Cell Cycle/DNA Damage
  4. PERK
  5. PERK Antagonist

PERK Antagonist

PERK Antagonist (1):

Cat. No. Product Name Effect Purity
  • HY-175504
    MLS6357
    		Antagonist
    MLS6357 is a D3 dopamine receptor (D3R)-selective positive allosteric modulator (PAM)-antagonist. MLS6357 exhibits antagonist activity in the D3R-mediated and the BRET-based β-arrestin recruitment assay with IC50s of 13 and 14 μM, and no activity for other DAR subtypes (D1R/D2R/D4R/D5R) (IC50 > 100 μM). MLS6357 is also an antagonist in the D3R-mediated Go-BRET assay with an IC50 of 17 μM. MLS6357 can be used for the study of neuropsychiatric disorders, including substance use disorder.