2. Signaling Pathways
  3. NF-κB
  4. NF-κB
  5. NF-κB1/p50 Isoform
  6. NF-κB1/p50 Degrader

NF-κB1/p50 Degrader

NF-κB1/p50 Degraders (2):

Cat. No. Product Name Effect Purity
  • HY-174138
    NF-κB degrader 1
    		Degrader
    NF-κB degrader 1 (Compound MD-1) is a NF-κB1 p105 subunit degrader. NF-κB degrader 1 shows anti-inflammatory activity (IC50 for inhibiting TNF-α is 2.02 μM, and for inhibiting NO is 5.40 μM). NF-κB degrader 1 induces p105 degradation dependent on the Cullin-RING ligase (CRL) SCFBTCP, suppressing NF-κB transcriptional activity. NF-κB degrader 1 is promising for research of inflammation-related diseases.
  • HY-175397
    Dth
    		Degrader
    Dth is a RNA aptamer-based PROTAC degrader. Dth can degrade a range of endogenous proteins (such as mCherry, p50, p65 and E2F1) by simply replacing the 3′ module on the RNA scaffold with the corresponding RNA aptamer of target protein (target aptamer). Pink: Target aptamer ligand (HY-176801); Blue: CRBN ligase ligand (HY-41547); Black: linker (HY-79577).