2. Signaling Pathways
  3. NF-κB
  4. NF-κB
  5. NF-κB Degrader

NF-κB Degrader

NF-κB Isoform Comparison

NF-κB Degraders (3):

Cat. No. Product Name Effect Purity
  • HY-49444
    EN450
    		Degrader 98.59%
    EN450 is a cysteine-reactive covalent molecular glue degrader targeting NF-κB. EN450 interacts with allosteric C111 in the E2 ubiquitin ligase UBE2D. EN450 induces the ternary complex formation between UBE2D and NFKB1. EN450 exerts its anti-proliferative effects through a Cullin E3 ligase and proteasome-dependent mechanism.
  • HY-174138
    NF-κB degrader 1
    		Degrader
    NF-κB degrader 1 (Compound MD-1) is a NF-κB1 p105 subunit degrader. NF-κB degrader 1 shows anti-inflammatory activity (IC50 for inhibiting TNF-α is 2.02 μM, and for inhibiting NO is 5.40 μM). NF-κB degrader 1 induces p105 degradation dependent on the Cullin-RING ligase (CRL) SCFBTCP, suppressing NF-κB transcriptional activity. NF-κB degrader 1 is promising for research of inflammation-related diseases.
  • HY-175397
    Dth
    		Degrader
    Dth is a RNA aptamer-based PROTAC degrader. Dth can degrade a range of endogenous proteins (such as mCherry, p50, p65 and E2F1) by simply replacing the 3′ module on the RNA scaffold with the corresponding RNA aptamer of target protein (target aptamer). Pink: Target aptamer ligand (HY-176801); Blue: CRBN ligase ligand (HY-41547); Black: linker (HY-79577).