2. Signaling Pathways
  3. Cell Cycle/DNA Damage
    Cytoskeleton
  4. Microtubule/Tubulin

Microtubule/Tubulin

Microtubule/Tubulin

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Microtubules are a component of the cytoskeleton, found throughout the cytoplasm. These tubular polymers of tubulin can grow as long as 50 micrometres, with an average length of 25 µm, and are highly dynamic. The outer diameter of a microtubule is about 24 nm while the inner diameter is about 12 nm. Microtubules are found in eukaryotic cells and are formed by the polymerization of a dimer of two globular proteins, alpha and beta tubulin. Tubulin is one of several members of a small family of globular proteins. The tubulin superfamily includes five distinct families, the alpha-, beta-, gamma-, delta-, and epsilon-tubulins and a sixth family which is present only in kinetoplastid protozoa. The most common members of the tubulin family are α-tubulin and β-tubulin, the proteins that make up microtubules. Microtubules are very important in a number of cellular processes. They are involved in maintaining the structure of the cell.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-14389
    LP-261
    		Inhibitor 99.94%
    LP-261 is a potent and orally active anti-mitotic agent and shows an inhibition of in vitro tubulin polymerization with an EC50 of 3.2 μM. LP-261 inhibits growth of a human non-small-cell lung tumor (NCI-H522) in vivo and can be used for cancer research.
    LP-261
  • HY-120786
    MPT0B014
    		Inhibitor 99.67%
    MPT0B014 is a tubulin polymerization inhibitor. MPT0B014 induces cancer cell apoptosis. MPT0B014 can be used for the research of cancer.
    MPT0B014
  • HY-146711
    Tubulin inhibitor 24
    		Inhibitor 99.94%
    Tubulin inhibitor 24 is a potent tubulin inhibitor. Tubulin inhibitor 24 inhibits tubulin polymerization. Tubulin inhibitor 24 induces cell cycle arrest at the G2/M phase in a concentration-dependent manner. Tubulin inhibitor 24 shows antitumor activity with no obvious toxicity.
    Tubulin inhibitor 24
  • HY-116852S
    Thiocolchicine-d3
    		Inhibitor ≥99.0%
    Thiocolchicine-d3 is deuterium labeled Thiocolchicine. Thiocolchicine, a derivative modified in the C Ring of Colchicine (HY-16569) with enhanced biological properties. Thiocolchicine is a potent inhibitor of tubulin polymerization (IC50=2.5 μM) and competitively binds to tubulin with a Ki of 0.7 μM. Thiocolchicine induces cell apoptosis. Thiocolchicine can be used as an ADC cytotoxin in ADC technology.
    Thiocolchicine-d<sub>3</sub>
  • HY-118748
    Suprafenacine
    		Inhibitor ≥98.0%
    Suprafenacine is a cell permeable, tubulin-destabilizing molecule which bind microtubules at the colchicine-binding site and inhibit polymerization. Suprafenacine can induce G2/M cell cycle arrest and apoptosis, and can be used for cancer research.
    Suprafenacine
  • HY-152156
    Tubulin inhibitor 11
    		Inhibitor 99.92%
    Tubulin inhibitor 11 is a potent and orally active tubulin inhibitor. Tubulin inhibitor 11 targets the Colchicine binding site on tubulin, inhibits tubulin polymerization, promotes mitotic blockade and apoptosis.
    Tubulin inhibitor 11
  • HY-B0628
    Vinflunine
    		Inhibitor
    Vinflunine is a type of fluorinated vinca alkaloid that has the ability to block mitosis and interact with tubulin.
    Vinflunine
  • HY-107116
    MAP4343
    MAP4343 is the 3-methylether derivative of Pregnenolone. MAP4343 binds in vitro to microtubule-associated protein 2 (MAP2), stimulates the polymerization of tubulin, enhances the extension of neurites and protects neurons against neurotoxic agents.
    MAP4343
  • HY-103257
    CHM-1
    		Inhibitor 99.57%
    CHM-1, a microtubule-destabilizing agent, inhibits tubulin polymerization. CHM-1 is a potent and selective antimitotic antitumor activity against human hepatocellular carcinoma. CHM-1 induces growth inhibition and apoptosis via G2-M phase arrest in human hepatocellular carcinoma cells by activation of Cdc2 kinase activity.
    CHM-1
  • HY-145989
    Aminobenzenesulfonic auristatin E
    		Inhibitor
    Aminobenzenesulfonic auristatin E is a agent-linker conjugate for ADC. Aminobenzenesulfonic auristatin E has potent antitumor activity by using Auristatin E (a cytotoxic tubulin modifier), linked via the ADC linker Aminobenzenesulfonic.
    Aminobenzenesulfonic auristatin E
  • HY-W355463
    3-Demethylthiocolchicine
    3-Demethylthiocolchicine is a colchicine (HY-16569) analog with broad-spectrum antitumor activity. 3-Demethylthiocolchicine has the same effects and activities as colchicine in blocking casein-induced amyloidosis, microtubule binding, and anti-inflammatory effects, with significantly lower toxicity.
    3-Demethylthiocolchicine
  • HY-151879
    Tubulin inhibitor 30
    		Inhibitor 99.77%
    Tubulin inhibitor 30 (Compound 15) is a tubulin assembly inhibitor with an IC50 of 0.52 μM. Tubulin inhibitor 30 can induce ferroptosis.
    Tubulin inhibitor 30
  • HY-111425
    SSE15206
    		Inhibitor 99.88%
    SSE15206 is a microtubule polymerization inhibitor (GI50 = 197 nM in HCT116 cells) that overcomes multidrug resistance. Causes aberrant mitosis resulting in G2/M arrest due to incomplete spindle formation in cancer cells.
    SSE15206
  • HY-118588
    Diminutol
    		Inhibitor 98.1%
    Diminutol is an inhibitor for NADP-dependent quinone oxidoreductase (NQO1), that is involved in microtubule morphogenesis and cell devision.
    Diminutol
  • HY-149249
    MY-943
    		Inhibitor 98.01%
    MY-943 is a potent tubulin polymerization and LSD1 inhibitor with anticancer activity. MY-943 induces G2/M phase arrest and apoptosis, and inhibits cell migration. MY-943 can be used for gastric cancer research.
    MY-943
  • HY-162089
    MY-1442
    		Inhibitor 99.25%
    MY-1442 (I-3) is a microtubulin polymerization inhibitor. MY-875 inhibits tubulin polymerization by targeting colchicine binding sites. MY-1442 has anticancer activity. MY-1442 can induce apoptosis of MGC-803 cells and inhibit cell migration.
    MY-1442
  • HY-160473
    TAM557
    		Inhibitor
    TAM557 is a cytotoxic tubulysin compound that can be used in enzymatic conjugation reactions.
    TAM557
  • HY-155962
    Tubulin polymerization-IN-47
    		Inhibitor 99.51%
    Tubulin polymerization-IN-47 (Compound 4h) is a tubulin polymerization inhibitor and mitotic inhibitor. Tubulin polymerization-IN-47 inhibits neuroblastoma cancer cell proliferation, with IC50s of 7 and 12 nM for Chp-134 and Kelly cell line.
    Tubulin polymerization-IN-47
  • HY-15584B
    Taltobulin hydrochloride
    		Inhibitor 99.34%
    Taltobulin hydrochloride (HTI-286 hydrochloride), a synthetic analogue of the tripeptide hemiasterlin, is a potent antimicrotubule agent that circumvents P-glycoprotein-mediated resistance in vitro and in vivo. Taltobulin hydrochloride inhibits the polymerization of purified tubulin, disrupts microtubule organization in cells, and induces mitotic arrest, as well as apoptosis.
    Taltobulin hydrochloride
  • HY-148265
    Antiproliferative agent-14
    		Inhibitor 98.76%
    Antiproliferative agent-14 (compound 3b) a potent tubulin polymerization inhibitor, with an IC50 of 3.41 μM. Antiproliferative agent-14 has excellent antiproliferative activity. Antiproliferative agent-14 possess the ability to arrest cells at G2/M phases of the cell cycle.
    Antiproliferative agent-14
Cat. No. Product Name / Synonyms Application Reactivity