2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Endogenous Metabolite

Endogenous Metabolite

Endogenous Metabolite

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Metabolite results when a drug is metabolized into a modified form which continues to produce effects. A metabolome in a given body fluid is influenced by endogenous factors such as age, sex, body composition and genetics as well as underlying pathologies.The levels of the enormous array of unique small-molecule metabolites are usually kept tightly regulated by the activity of a very large array of enzymes and transporters responsible for the production, transformation, degradation, and compartmentalization of these small molecules.The levels of the endogenous small molecules present in the brain are normally tightly regulated.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-N2334S
    Glycochenodeoxycholic acid-d4
    		99.90%
    Glycochenodeoxycholic acid-d4 is the deuterium labeled Glycochenodeoxycholic acid. Glycochenodeoxycholic acid (Chenodeoxycholylglycine) is a bile acid formed in the liver from chenodeoxycholate and glycine. It acts as a detergent to solubilize fats for absorption and is itself absorbed. Glycochenodeoxycholic acid (Chenodeoxycholylglycine) induces hepatocyte apoptosis.
    Glycochenodeoxycholic acid-d<sub>4</sub>
  • HY-106353
    Smilagenin
    		98.0%
    Smilagenin (SMI) is a small-molecule steroidal sapogenin from Anemarrhena asphodeloides and Pelargonium hortorum widely used in traditional Chinese medicine for treating chronic neurodegeneration diseases. Smilagenin (SMI) improves memory of aged rats by increasing the muscarinic receptor subtype 1 (M1)-receptor density. Smilagenin (SMI) attenuates Aβ(25-35)-induced neurodegenerationvia stimulating the gene expression of brain-derived neurotrophic factor, may represents a novel therapeutic strategy for AD.
    Smilagenin
  • HY-78036
    Mesaconic acid
    		99.95%
    Mesaconic acid is an active product that can be extracted from Saxifraga stolonifera. Mesaconic acid is used as a fire retardant and is a competitive inhibitor of fumarate reduction.
    Mesaconic acid
  • HY-B0152A
    Adenine hydrochloride
    		98.0%
    Adenine hydrochloride (6-Aminopurine hydrochloride), a purine, is one of the four nucleobases in the nucleic acid of DNA. Adenine hydrochloride acts as a chemical component of DNA and RNA. Adenine hydrochloride also plays an important role in biochemistry involved in cellular respiration, the form of both ATP and the cofactors (NAD and FAD), and protein synthesis.
    Adenine hydrochloride
  • HY-113316B
    (S)-Salsolinol
    		99.64%
    (S)-Salsolinol ((-)-Salsolinol) is a dopamine-derived endogenous metabolite.
    (S)-Salsolinol
  • HY-B1945S
    DEHP-d4
    		99.80%
    DEHP-d4 is the deuterium labeled DEHP. DEHP (Bis(2-ethylhexyl) phthalate) is an endogenous metabolite.
    DEHP-d<sub>4</sub>
  • HY-111769
    Taurochenodeoxycholate-3-sulfate
    		98.0%
    Taurochenodeoxycholate-3-sulfate is a bile salt found in urine.
    Taurochenodeoxycholate-3-sulfate
  • HY-113128C
    (Rac)-sn-Glycerol 3-phosphate
    (Rac)-sn-Glycerol 3-phosphate is an a-site substrate analogue. (Rac)-sn-Glycerol 3-phosphate is bound to the a-site, the rate of reaction of indole and nucleophilic indole analogues with E(A-A) is strongly inhibited.
    (Rac)-sn-Glycerol 3-phosphate
  • HY-113380
    (S)-β-Aminoisobutyric acid
    		99.59%
    (S)-β-Aminoisobutyric acid is a non-protein amino acid originating from the catabolism of thymine and valine.
    (S)-β-Aminoisobutyric acid
  • HY-45609
    L-Cysteine S-sulfate sodium hydrate
    		98.0%
    L-Cysteine S-sulfate sodium hydrate is a potent N-methyl-d-aspartate (NMDA) glutamatergic receptors agonist. L-Cysteine S-sulfate sodium hydrate is the substrate for cystine lyase, it can be used in mass spectrometry operations.
    L-Cysteine S-sulfate sodium hydrate
  • HY-P2887
    Acetate kinase (ACK)
    Acetate kinase (ACK) is an enzyme widely distributed in bacteria and archaea. In the presence of ATP and divalent cations, it catalyzes the phosphorylation of acetate and promotes the production of acetyl-CoA. Often used in biochemical research.
    Acetate kinase (ACK)
  • HY-128442
    Phenyl sulfate
    		99.56%
    Phenyl sulfate is an orally active gut microbiota-derived metabolite. Phenyl sulfate induces albuminuria and podocyte damage in experimental models of diabetes. Phenyl sulfate can be used as a disease marker and future therapeutic target in diabetic kidney disease.
    Phenyl sulfate
  • HY-B1899A
    Taurodeoxycholic acid sodium hydrate
    		99.75%
    Taurodeoxycholic acid sodium hydrate (Sodium taurodeoxycholate monohydrate), a bile acid, is an amphiphilic surfactant molecule synthesized from cholesterol in the liver. Taurodeoxycholic acid sodium hydrate activates the S1PR2 pathway in addition to the TGR5 pathway.
    Taurodeoxycholic acid sodium hydrate
  • HY-N0304R
    L-DOPA (Standard)
    L-DOPA (Standard) is the analytical standard of L-DOPA. This product is intended for research and analytical applications. L-DOPA (Levodopa) is an orally active metabolic precursor of neurotransmitters dopamine. L-DOPA can cross the blood-brain barrier and is converted into dopamine in the brain. L-DOPA has anti-allodynic effects and the potential for Parkinson's disease.
    L-DOPA (Standard)
  • HY-113465
    Leukotriene E4
    		99.80%
    Leukotriene E4 (LTE4) is produced by the action of dipeptidase on LTD4. Leukotriene E4 is one of the constituents of slow-reacting substance of anaphylaxis (SRS-A). Leukotriene E4 accumulates in both plasma and urine and urinary excretion of Leukotriene E4 is most often used as an indicator of asthma.
    Leukotriene E4
  • HY-B0757A
    (±)-α-Tocopherol nicotinate
    		99.80%
    (±)-α-Tocopherol nicotinate, vitamin E - nicotinate, is an orally active fat-soluble antioxidant that prevents lipid peroxidation in cell membranes. (±)-α-Tocopherol nicotinate is hydrolysed in the blood to α -tocopherol and niacin and may be used in studies of related vascular diseases.
    (±)-α-Tocopherol nicotinate
  • HY-107830
    Methyl cholate
    		99.81%
    Methyl cholate is a methyl ester of bile acid and sterol esters that can act as supramolecular carriers for aldoses (e.g., glucose, galactose, mannose). Methyl cholate selectively binds to aldoses to form non-covalent complexes and migrates in supported liquid membranes (SLMs), thereby facilitating the transport of sugars. Cholic acid is one of the major bile acids produced by the liver and is synthesized from cholesterol. Methyl cholate can be used to study the selective separation and transport of carbohydrates.
    Methyl cholate
  • HY-D0185
    2'-Deoxyguanosine monohydrate
    		99.70%
    2'-Deoxyguanosine monohydrate is a nucleoside composed of guanine and deoxyribose, and is one of the basic building blocks of DNA. In the oxidation reaction mediated by singlet oxygen 1O2, the guanine base of 2'-Deoxyguanosine is easily oxidized to generate two major products, 4,8-dihydro-4-hydroxy-8-oxodG and 7,8-dihydro-8-oxodG. The oxidation products of 2'-Deoxyguanosine monohydrate may participate in DNA damage, which may affect gene expression or induce cancer.
    2'-Deoxyguanosine monohydrate
  • HY-126996
    Triiodothyronine sulfate
    		98.0%
    Triiodothyronine sulfate is the main metabolite of thyroid hormone triiodothyronine (T3). Triiodothyronine is an active form of thyroid hormone, which binds to β1 thyroid hormone receptor (TRβ1), and activates its activity.
    Triiodothyronine sulfate
  • HY-N0771S
    L-Isoleucine-13C6
    		99.77%
    L-Isoleucine-13C6 is the 13C-labeled L-Isoleucine. L-isoleucine is a nonpolar hydrophobic amino acid. L-Isoleucine is an essential amino acid.
    L-Isoleucine-<sup>13</sup>C<sub>6</sub>
Cat. No. Product Name / Synonyms Application Reactivity