2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Endogenous Metabolite

Endogenous Metabolite

Endogenous Metabolite

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Metabolite results when a drug is metabolized into a modified form which continues to produce effects. A metabolome in a given body fluid is influenced by endogenous factors such as age, sex, body composition and genetics as well as underlying pathologies.The levels of the enormous array of unique small-molecule metabolites are usually kept tightly regulated by the activity of a very large array of enzymes and transporters responsible for the production, transformation, degradation, and compartmentalization of these small molecules.The levels of the endogenous small molecules present in the brain are normally tightly regulated.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-32351AS1
    Calcifediol-13C5 monohydrate
    Calcifediol-13C5 monohydrate is the 13C-labeled Calcifediol monohydrate. Calcifediol monohydrate (25-hydroxy Vitamin D3 monohydrate), is an effective VDR ligand and VD supplement. Calcifediol is a prohormone of the vitamin D endocrine system (VDES) and is hydroxylated in the liver to produce the active form, calcitriol. Calcifediol can rapidly increase serum VD levels.
    Calcifediol-<sup>13</sup>C<sub>5</sub> monohydrate
  • HY-W017613R
    (Ethoxymethyl)benzene (Standard)
    (Ethoxymethyl)benzene (Standard) is the analytical standard of (Ethoxymethyl)benzene. This product is intended for research and analytical applications. (Ethoxymethyl)benzene is an endogenous metabolite.
    (Ethoxymethyl)benzene (Standard)
  • HY-W004301
    Dodecanal
    		99.35%
    Dodecanal is composition of essential oil that can be found in Coriandrum sativum L.
    Dodecanal
  • HY-102015S
    6-Biopterin-d3
    6-Biopterin-d3 (L-Biopterin-d3) is deuterium labeled 6-Biopterin. 6-Biopterin (L-Biopterin), a pterin derivative, is a NO synthase cofactor.
    6-Biopterin-d<sub>3</sub>
  • HY-W020215R
    Tricarballylic acid (Standard)
    Tricarballylic acid (Standard) is the analytical standard of Tricarballylic acid (HY-W020215). This product is intended for research and analytical applications. Tricarballylic acid is an orally active compound that can be produced by rumen microorganisms and has the activity of chelating magnesium. Tricarballylic acid is also a competitive inhibitor of aconitate hydratase, with a Ki value of 0.52 mM. Tricarballylic acid can inhibit the oxidation of acetate in the citric acid cycle and can be used in the research of ruminant tissue metabolism and grass tetany syndrome. In addition, Tricarballylic acid can be used to synthesize specific complexes and produce plasticizers.
    Tricarballylic acid (Standard)
  • HY-N1224
    (22E,24R)-Stigmasta-4,22-dien-3-one
    (22E,24R)-Stigmasta-4,22-dien-3-one (compound 28) is a steroid isolated from sponges.
    (22E,24R)-Stigmasta-4,22-dien-3-one
  • HY-118566
    5α-Androstenone
    5α-Androstenone is an odor molecule that can be isolated from porcine adipose tissue.
    5α-Androstenone
  • HY-N0229S11
    L-Alanine-1-13C,15N
    		98%
    L-Alanine-1-13C,15N is the 13C- and 15N-labeled L-Alanine. L-Alanine is a non-essential amino acid, involved in sugar and acid metabolism, increases immunity, and provides energy for muscle tissue, brain, and central nervous system.
    L-Alanine-1-<sup>13</sup>C,<sup>15</sup>N
  • HY-113239S2
    (Rac)-Hydroxycotinine-d3
    (Rac)-Hydroxycotinine-d3 is deuterated labeled Hydroxycotinine (HY-113239). Hydroxycotinine is the main nicotine metabolite detected in smokers urine.
    (Rac)-Hydroxycotinine-d<sub>3</sub>
  • HY-E70622
    α-L-Iduronidase
    α-L-Iduronidase is key in the catabolism of glycosaminoglycans (GAG) heparan and dermatan sulfate. Measurement of α-L-iduronidase specific enzyme activity is an essential parameter for those studying mucopolysaccharidoses (MPS) type I.
    α-L-Iduronidase
  • HY-118295
    Pyrimidine-indole hybrid
    Pyrimidine-indole hybrid is a compound that inhibits ciliogenesis and has the activity of antagonizing the Hedgehog signaling pathway by destabilizing microtubules. Pyrimidine-indole hybrid exerts its biological effects by inhibiting ciliogenesis and deconstructing the stable form of α-tubulin. Pyrimidine-indole hybrid has shown its unique mechanism of action in in vitro cell experiments and zebrafish embryo models, interfering with microtubule dynamics.
    Pyrimidine-indole hybrid
  • HY-129099AR
    N-Desmethyltamoxifen hydrochloride (Standard)
    N-Desmethyltamoxifen (hydrochloride) (Standard) is the analytical standard of N-Desmethyltamoxifen (hydrochloride). This product is intended for research and analytical applications. N-Desmethyltamoxifen hydrochloride is the major metabolite of tamoxifen in humans. N-Desmethyltamoxifen, a poor antiestrogen, is a ten-fold more potent protein kinase C (PKC) inhibitor than Tamoxifen. N-Desmethyltamoxifen hydrochloride is also a potent regulator of ceramide metabolism in human AML cells, limiting ceramide glycosylation, hydrolysis, and sphingosine phosphorylation[1][2][3].
    N-Desmethyltamoxifen hydrochloride (Standard)
  • HY-B1779S5
    Sucrose-13C6
    Sucrose-13C6 is the 13C labeled Sucrose. Sucrose (D-(+)-Saccharose) is a disaccharide which is composed of two monosaccharides, glucose and fructose. Sucrose can be applied in some animal models, including metabolic disease, obesity, diet on preference, and diabetes, et al.
    Sucrose-<sup>13</sup>C<sub>6</sub>
  • HY-N1150S5
    Thymidine-2′-13C
    Thymidine-2′-13C is the 13C labeled Thymidine. Thymidine, a specific precursor of deoxyribonucleic acid, is used as a cell synchronizing agent. Thymidine is a DNA synthesis inhibitor that can arrest cell at G1/S boundary, prior to DNA replication.
    Thymidine-2′-<sup>13</sup>C
  • HY-P3185
    beta-Galactose dehydrogenase
    beta-Galactose dehydrogenase can make conversion of galactose to galactonolactone and the concomitant reduction of NAD to the fluorescent NADH. beta-Galactose dehydrogenase can be used for the determination of galactose.
    beta-Galactose dehydrogenase
  • HY-W711807
    D-Arabitol-d7
    D-Arabitol-d7 is the deuterium labeled D-Arabitol (HY-N3686). D-Arabitol is a polyol and its accumulation may cause a neurotoxic effect in human.
    D-Arabitol-d<sub>7</sub>
  • HY-116374R
    Glycolithocholic acid (Standard)
    Glycolithocholic acid (Standard) is the analytical standard of Glycolithocholic acid. This product is intended for research and analytical applications. Glycolithocholic acid (Lithocholylglycine), an endogenous metabolite, is a glycine-conjugated secondary bile acid. Glycolithocholic acid can be used to diagnose ulcerative colitis (UC), non-alcoholic steatohepatitis (NASH) and primary sclerosing cholangitis (PSC).
    Glycolithocholic acid (Standard)
  • HY-107748A
    5'-Guanidinonaltrindole TFA
    5'-Guanidinonaltrindole TFA is a selective kappa-opioid receptor antagonist with significant opioid antagonist activity. 5'-Guanidinonaltrindole TFA exhibits 5 times the antagonistic potency of the prototypical kappa-opioid receptor antagonist norbinatorphimine in smooth muscle preparations, with a selectivity ratio exceeding 500 times. Binding and functional studies of 5'-Guanidinonaltrindole TFA showed pA(2) values comparable to smooth muscle data. 5'-Guanidinonaltrindole TFA is regarded as a potentially valuable pharmacological tool for studying opioids due to its high selectivity and potency.
    5'-Guanidinonaltrindole TFA
  • HY-W751961
    2'-Deoxyadenosine-155
    2'-Deoxyadenosine-15N5 is the 15N5-labeled version of 2'-Deoxyadenosine (HY-W040329). 2'-Deoxyadenosine is a nucleoside adenosine derivative that can pair with deoxythymidine in double-stranded DNA.
    2'-Deoxyadenosine-<sup>15</supN<sub>5</sub>
  • HY-112537A
    Dipotassium glucose-6-phosphate, 98%
    D-Glucose-6-phosphate dipotassium salt dihydrate is a glucose sugar phosphorylated at the hydroxy group on carbon 6.
    Dipotassium glucose-6-phosphate, 98%
Cat. No. Product Name / Synonyms Application Reactivity