2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Endogenous Metabolite

Endogenous Metabolite

Endogenous Metabolite

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Metabolite results when a drug is metabolized into a modified form which continues to produce effects. A metabolome in a given body fluid is influenced by endogenous factors such as age, sex, body composition and genetics as well as underlying pathologies.The levels of the enormous array of unique small-molecule metabolites are usually kept tightly regulated by the activity of a very large array of enzymes and transporters responsible for the production, transformation, degradation, and compartmentalization of these small molecules.The levels of the endogenous small molecules present in the brain are normally tightly regulated.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-12145
    CP-99994 hydrochloride
    CP-99994 hydrochloride is a Tachykinin neurokinin 1 (NK-1) receptor antagonist with a Ki of 0.25 nM. CP-99994 hydrochloride prevents colorectal sensitization in the context of visceral hypersensitivity. CP-99994 hydrochloride reduces colorectal hypersensitivity induced by acetic acid injections in a model of bladder-colon cross-sensitization. CP-99994 hydrochloride attenuates the neuroglial interactions and MAPK-p38 phosphorylation associated with visceral hypersensitivity.
    CP-99994 hydrochloride
  • HY-W011956R
    6-Hydroxymelatonin (Standard)
    6-Hydroxymelatonin (Standard) is the analytical standard of 6-Hydroxymelatonin. This product is intended for research and analytical applications. 6-Hydroxymelatonin is a primary metabolic of Melatonin, which is metabolized by cytochrome P450 (CYP) 1A2.
    6-Hydroxymelatonin (Standard)
  • HY-W727757
    Pristanic acid-d6 (>90%)
    Pristanic acid-d6 (>90%) is the deuterium labeled Pristanic acid (HY-113024). Pristanic acid is an endogenous metabolite present in Blood that can be used for the research of Alpha Methylacyl CoA Racemase Deficiency and Zellweger Syndrome.
    Pristanic acid-d<sub>6</sub> (>90%)
  • HY-P2837
    Oxaloacetate decarboxylase
    Oxaloacetate decarboxylase catalyzes the irreversible decarboxylation of oxaloacetate to pyruvate and COIC2. Oxaloacetate decarboxylase is a member of the sodium ion transport decarboxylase (NaT-DC) enzyme family. Oxaloacetate decarboxylase converts the chemical energy of the decarboxylation reaction into an electrochemical gradient of Na+ ions across the membrane.
    Oxaloacetate decarboxylase
  • HY-N0486S6
    L-Leucine-2-13C,15N
    L-Leucine-2-13C,15N is the 13C- and 15N-labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway.
    L-Leucine-2-<sup>13</sup>C,<sup>15</sup>N
  • HY-N8796
    2',4'-Dihydroxy-4,6'-diMethoxydihydrochalcone
    2',4'-Dihydroxy-4,6'-diMethoxydihydrochalcone is a dihydrochalcone compound isolated from Iryanthera juruensis Warb. 2',4'-Dihydroxy-4,6'-diMethoxydihydrochalcone is a major cytotoxic metabolite when tested against a panel of cancer cell lines.
    2',4'-Dihydroxy-4,6'-diMethoxydihydrochalcone
  • HY-B0151S1
    Pregnenolone-13C2,d2
    Pregnenolone-13C2,d2 is the deuterium and 13C labeled Pregnenolone (HY-B0151). Pregnenolone is a powerful neurosteroid, the main precursor of various steroid hormones including steroid ketones. Pregnenolone acts as a signaling-specific inhibitor of cannabinoid CB1 receptor, inhibits the effects of tetrahydrocannabinol (THC) that are mediated by the CB1 receptors. Pregnenolone can protect the brain from cannabis intoxication. Pregnenolone is also a TRPM3 channel activator, and also can weakly activate TRPM1 channels.
    Pregnenolone-<sup>13</sup>C<sub>2</sub>,d<sub>2</sub>
  • HY-111259
    Ro 31-1118 free base
    Ro 31-1118 Free base is a compound exhibiting weak antihypertensive activity in patients with mild hypertension. Ro 31-1118 Free base demonstrated a reduction in heart rates and blood pressure post-exercise at varying doses. Ro 31-1118 Free base exhibited linear pharmacokinetics within the 10-80 mg dose range. Ro 31-1118 Free base showed no significant impact on diastolic blood pressure or adverse effects during the study.
    Ro 31-1118 free base
  • HY-123706
    Salinosporamide C
    Salinosporamide C (compound 4) is a decarboxylated pyrrole analog. Salinosporamide C is the secondary metabolite of the obligate marine actinomycete Salinispora tropical.
    Salinosporamide C
  • HY-B1465S4
    1-Hexadecanol-d4
    1-Hexadecanol-d4 is the deuterium labeled 1-Hexadecanol. 1-Hexadecanol is a fatty alcohol, a lipophilic substrate.
    1-Hexadecanol-d<sub>4</sub>
  • HY-165109
    1,3-Dioleoyl-2-lauroyl glycerol
    1,3-Dioleoyl-2-lauroyl glycerol (1,3-Olein-2-laurin), a compound in the triglyceride composition of human milk, was identified and quantified by liquid chromatography-mass spectrometry, and a targeted analytical approach was developed.
    1,3-Dioleoyl-2-lauroyl glycerol
  • HY-P2802A
    α-Glucosidase, bacillus stearothermophilus
    α-Glucosidase, bacillus stearothermophilus is a carbohydrase enzyme that catalyzes the release of α-glucose molecules. α-Glucosidase, bacillus stearothermophilus retains exoglycosidases, which hydrolyze α-glucosidic linkage at the nonreducing end of a substrate.
    α-Glucosidase, bacillus stearothermophilus
  • HY-A0132S9
    N-Acetyl-D-glucosamine-13C3,15N
    N-Acetyl-D-glucosamine-13C3,15N is the 13C and 15N labeled N-Acetyl-D-glucosamine. N-Acetyl-D-Glucosamine (N-Acetyl-2-amino-2-deoxy-D-glucose) is a monosaccharide derivative of gluc.
    N-Acetyl-D-glucosamine-<sup>13</sup>C<sub>3</sub>,<sup>15</sup>N
  • HY-B2219S5
    Stearic acid-9,10-d2
    Stearic acid-9,10-d2 is the deuterium labeled Stearic acid. Stearic acid is a long chain dietary saturated fatty acid which exists in many animal and vegetable fats and oils.
    Stearic acid-9,10-d<sub>2</sub>
  • HY-113400S
    Cytidine diphosphate-15N3 dilithium
    Cytidine diphosphate-15N3 dilithium is 15N labeled Cytidine diphosphate (HY-113400). Cytidine diphosphate is a nucleoside diphosphate that acts as a carrier for phosphorylcholine, diacylglycerol, and other molecules during phospholipid synthesis.
    Cytidine diphosphate-<sup>15</sup>N<sub>3</sub> dilithium
  • HY-B0125AS
    Ofloxacin-d8 hydrochloride
    Ofloxacin-d8 (hydrochloride) is deuterium labeled Ofloxacin (hydrochloride).
    Ofloxacin-d<sub>8</sub> hydrochloride
  • HY-W750488
    Glycolithocholic acid-d5
    Glycolithocholic acid-d5 (Lithocholylglycine-d5) is the deuterium labeled Glycolithocholic acid (HY-116374). Glycolithocholic acid (Lithocholylglycine), an endogenous metabolite, is a glycine-conjugated secondary bile acid. Glycolithocholic acid can be used to diagnose ulcerative colitis (UC), non-alcoholic steatohepatitis (NASH) and primary sclerosing cholangitis (PSC).
    Glycolithocholic acid-d<sub>5</sub>
  • HY-B0389S24
    D-Glucose-d4
    		≥99.0%
    D-Glucose-d4 is the deuterium labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molec
    D-Glucose-d<sub>4</sub>
  • HY-W768571
    Pseudouridine-13C,15N2
    Pseudouridine-13C,15N2 is the 13C- and 15N-labeled Pseudouridine (HY-113061). Pseudouridine is an isomer of uridine and the most abundant modified nucleoside in non-coding RNA. It fine-tunes and stabilizes regional structures in rRNA and tRNA, maintaining their functions in mRNA decoding, ribosome assembly, processing, and translation. Pseudouridine-modified tRNA fragments can inhibit aberrant protein synthesis and hold promise for research on myelodysplastic syndrome (MDS)-related leukemia..
    Pseudouridine-<sup>13</sup>C,<sup>15</sup>N<sub>2</sub>
  • HY-W145699
    D-myo-Inositol 4-monophosphate
    D-myo-Inositol 4-mono-phosphate, also known as IMP, is a phosphorylated form of inositol that is commonly found in various metabolic pathways, especially in the biosynthesis of phospholipids and cell signaling molecules. D-myo-Inositol 4-mono-phosphate has unique chemical properties that make it an important intermediate in the production of second messengers, such as inositol triphosphate (IP3) and diacylglycerol (DAG), which signal in cells plays a key role in. D-myo-Inositol 4-mono-phosphate is also used in dietary supplements and pharmaceuticals because of its potential health benefits, including improved insulin sensitivity and cognitive function.
    D-myo-Inositol 4-monophosphate
Cat. No. Product Name / Synonyms Application Reactivity