2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Endogenous Metabolite

Endogenous Metabolite

Endogenous Metabolite

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Metabolite results when a drug is metabolized into a modified form which continues to produce effects. A metabolome in a given body fluid is influenced by endogenous factors such as age, sex, body composition and genetics as well as underlying pathologies.The levels of the enormous array of unique small-molecule metabolites are usually kept tightly regulated by the activity of a very large array of enzymes and transporters responsible for the production, transformation, degradation, and compartmentalization of these small molecules.The levels of the endogenous small molecules present in the brain are normally tightly regulated.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-125628
    Kahalalide A
    Kahalalide A is an anti-mycobacterial compound with antimicrobial activity. Kahalalide A is derived from the marine mollusk Elysia rufescens. Kahalalide A has attracted extensive attention in natural product research due to its potential medicinal value.
    Kahalalide A
  • HY-113126A
    3-Hydroxyisobutyric acid sodium
    3-Hydroxyisobutyric acid sodium is an intermediate in the metabolic pathways of L-valine and thymine, and can be found in urine. 3-Hydroxyisobutyric acid sodium is a secreted mediator of endothelial cell fatty acid transport and insulin resistance. 3-Hydroxyisobutyric acid sodium can also inhibit key enzymes of energy metabolism in the cerebral cortex of young rats. The levels of 3-Hydroxyisobutyric acid sodium are closely related to various diseases such as 3-hydroxyisobutyric aciduria, diabetes, and ketoacidosis.
    3-Hydroxyisobutyric acid sodium
  • HY-W016009S3
    2'-Deoxyadenosine-5'-monophosphate-13C10 dilithium
    2'-Deoxyadenosine-5'-monophosphate-13C10 dilithium is 13C-labeled 2'-Deoxyadenosine-5'-monophosphate (HY-W016009). 2′-Deoxyadenosine 5′-monophosphate, a nucleic acid AMP derivative, is a deoxyribonucleotide found in DNA. 2′-Deoxyadenosine 5′-monophosphate can be used to study adenosine-based interactions during DNA synthesis and DNA damage.
    2'-Deoxyadenosine-5'-monophosphate-<sup>13</sup>C<sub>10</sub> dilithium
  • HY-W018772S
    D-Ribose-18O
    D-Ribose-18O is the 18O labeled D-Ribose. D-Ribose is an energy enhancer, and acts as a sugar moiety of ATP, and widely used as a metabolic therapy supplement for chronic fatigue syndrome or cardiac energy metabolism. D-Ribose is active in protein glycati
    D-Ribose-<sup>18</sup>O
  • HY-110189S1
    Pregnenolone monosulfate-d4 sodium
    Pregnenolone monosulfate-d4 (sodium) is the deuterium labeled Pregnenolone monosulfate. Pregnenolone monosulfate sodium (3β-Hydroxy-5-pregnen-20-one monosulfate sodium) is a powerful neurosteroid, the main precursor of various steroid hormones including steroid ketones. Pregnenolone monosulfate sodium acts as a signaling-specific inhibitor of cannabinoid CB1 receptor, inhibits the effects of tetrahydrocannabinol (THC) that are mediated by the CB1 receptors. Pregnenolone monosulfate sodium can protect the brain from cannabis intoxication. Pregnenolone monosulfate sodium is also a TRPM3 channel activator, and also can weakly activate TRPM1 channels.
    Pregnenolone monosulfate-d<sub>4</sub> sodium
  • HY-N0379S19
    D-Mannose-d-4
    D-Mannose-d-4 is the deuterium labeled D-Mannose. D-Mannose is a carbohydrate, which plays an important role in human metabolism, especially in the glycosylationof specific prote.
    D-Mannose-d-4
  • HY-W010452S
    3-Hydroxybutyric acid-d2 sodium
    3-Hydroxybutyric acid-d2 (sodium) is the deuterium labeled 3-Hydroxybutyric acid sodium. 3-Hydroxybutyric acid sodium (β-Hydroxybutyric acid sodium) is a metabolite that is elevated in type I diabetes. 3-Hydroxybutyric acid sodium can modulate the properties of membrane lipids.
    3-Hydroxybutyric acid-d<sub>2</sub> sodium
  • HY-D0186S3
    2'-Deoxyuridine-5′-13C
    2'-Deoxyuridine-5′-13C is the 13C labeled 2'-Deoxyuridine. 2'-Deoxyuridine could increase chromosome breakage and results in a decreased thymidylate synthetase activity. A known use of 2'-Deoxyuridine is as a precursor in the synthesis of Edoxud[1]
    2'-Deoxyuridine-5′-<sup>13</sup>C
  • HY-112530S
    1,2-Distearoyl-sn-glycero-3-phosphorylethanolamine-d70
    		≥99.0%
    1,2-Distearoyl-sn-glycero-3-phosphorylethanolamine-d70 is deuterium labeled 1,2-Distearoyl-sn-glycero-3-phosphorylethanolamine. 1,2-Distearoyl-sn-glycero-3-phosphorylethanolamine (DSPE) is a phosphoethanolamine (PE) lipid that can be used in the synthesis
    1,2-Distearoyl-sn-glycero-3-phosphorylethanolamine-d<sub>70</sub>
  • HY-N0684S1
    Vitamin K1-d4
    Vitamin K1-d4 is the deuterium labeled Vitamin K1. Vitamin K1 a naturally occurring vitamin required for blood coagulation and bone and vascular metabolism.
    Vitamin K1-d<sub>4</sub>
  • HY-A0115R
    Ramiprilat (Standard)
    Alvimopan (dihydrate) (Standard) is the analytical standard of Alvimopan (dihydrate). This product is intended for research and analytical applications. Alvimopan dihydrate (ADL 8-2698 dihydrate) is a potent, selective, orally active and reversible μ-opioid receptor antagonist, with an IC50 of 1.7 nM. Alvimopan dihydrate has selectivity for μ-opioid receptor (Ki=0.47 nM) over κ- and δ-opioid receptors (Kis=100, 12 nM, respectively). Alvimopan dihydrate can be used for the research of postoperative ileus.
    Ramiprilat (Standard)
  • HY-Y1644R
    (E)-Crotonic acid (Standard)
    (E)-Crotonic acid (Standard) is the analytical standard of (E)-Crotonic acid. This product is intended for research and analytical applications. (E)-Crotonic acid is an endogenous metabolite.
    (E)-Crotonic acid (Standard)
  • HY-P2802B
    α-Glucosidase, rice
    α-Glucosidase, rice is a carbohydrase enzyme that catalyzes the release of α-glucose molecules. α-Glucosidase, rice retains exoglycosidases, which hydrolyze α-glucosidic linkage at the nonreducing end of a substrate.
    α-Glucosidase, rice
  • HY-B1659AS
    D-Glycerol-3-13C
    D-Glycerol-3-13C is the 13C labeled D-Glycerol.
    D-Glycerol-3-<sup>13</sup>C
  • HY-N0469S
    L-Lysine-d3 hydrochloride
    L-Lysine-d3 (hydrochloride) is the deuterium labeled L-Lysine. L-lysine is an essential amino acid with important roles in connective tissues and carnitine synthesis, energy production, growth in children, and maintenance of immune functions.
    L-Lysine-d<sub>3</sub> hydrochloride
  • HY-W753593
    N4-Acetylcytidine-13C5
    N4-Acetylcytidine-13C5 is the 13C-labeled N4-Acetylcytidine (HY-W019670). N4-acetylcytidine (N4A) is an endogenous nucleoside metabolite from the degradation of tRNA. N4-Acetylcytidine is formed by N-acetyltransferase 10 and other enzymes. N4-acetylcytidine might sustain NLRP3 inflammasome activation via induction of HMGB1 expression and releasee. N4-Acetylcytidine modifies mRNA, tRNA and rRNA, affecting their stability, translation efficiency (such as enterovirus 71 RNA). N4-Acetylcytidine is used in the study of cancer, neuroinflammatory diseases, viral infections and obesity.
    N4-Acetylcytidine-<sup>13</sup>C<sub>5</sub>
  • HY-135880A
    OMDM-4
    OMDM-4 is a selective and metabolically stable inhibitor of anandamide cellular uptake (ACU), with a Ki 17.7 μM.
    OMDM-4
  • HY-W040329S3
    2'-Deoxyadenosine-15N5,d13
    2'-Deoxyadenosine-15N5,d13 is deuterium and 15N labeled 2'-Deoxyadenosine (HY-W040329). 2′-Deoxyadenosine is an adenine nucleoside that inhibits glucose-stimulated insulin release. 2′-Deoxyadenosine inhibits glucose-stimulated increases seen in islet cyclic AMP (cAMP) accumulation. 2'-Deoxyadenosine activates caspase-3 and promotes apoptosis. 2'-Deoxyadenosine inhibits the activity of S-adenosyl-L-homocysteine hydrolase (SAHH). 2'-Deoxyadenosine inhibits the growth of various cells. 2'-Deoxyadenosine has an anticancer effect on colon cancer.
    2'-Deoxyadenosine-<sup>15</sup>N<sub>5</sub>,d<sub>13</sub>
  • HY-P10296
    p60 (217–225)
    p60 (217–225) is the subdominant epitope of Listeria monocytogenes, which combines with H-2Kd MHC class I molecules.
    p60 (217–225)
  • HY-141578R
    C18:1-Ceramide (Standard)
    C18:1-Ceramide (Standard) is the analytical standard of C18:1-Ceramide. This product is intended for research and analytical applications. C18:1-Ceramide is a ceramide subspecies. C18:1-Ceramide can be used in the study of type 2 diabetes
    C18:1-Ceramide (Standard)
Cat. No. Product Name / Synonyms Application Reactivity