2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Endogenous Metabolite

Endogenous Metabolite

Endogenous Metabolite

Related Products

PDF 48.35 MB

Metabolite results when a drug is metabolized into a modified form which continues to produce effects. A metabolome in a given body fluid is influenced by endogenous factors such as age, sex, body composition and genetics as well as underlying pathologies.The levels of the enormous array of unique small-molecule metabolites are usually kept tightly regulated by the activity of a very large array of enzymes and transporters responsible for the production, transformation, degradation, and compartmentalization of these small molecules.The levels of the endogenous small molecules present in the brain are normally tightly regulated.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-W010450S3
    Thymine-13C
    Thymine-13C is the 13C labeled Thymine. Thymine is one of the four nucleobases in the nucleic acid of DNA and can be a target for actions of 5-fluorouracil (5-FU) in cancer treatment, with a Km of 2.3 μM.
    Thymine-<sup>13</sup>C
  • HY-N0092S1
    Inosine-13C
    Inosine-13C is the 13C labeled Inosine. Inosine is an endogenous purine nucleoside produced by catabolism of adenosine. Inosine has anti-inflammatory, antinociceptive, immunomodulatory and neuroprotective effects. Inosine is an agonist for adenosine A1 (A1R) and A2A (A2AR) receptors.
    Inosine-<sup>13</sup>C
  • HY-113225
    Guanosine triphosphate
    Guanosine triphosphate is a native nucleotide. The derivatives of GTP may be used as specific inhibitors against COVID-19.
    Guanosine triphosphate
  • HY-13930R
    Miquelianin (Standard)
    Miquelianin (Standard) is the analytical standard of Miquelianin. This product is intended for research and analytical applications. Miquelianin (Quercetin 3-O-glucuronide) is a metabolite of quercetin and a type of natural flavonoid. Miquelianin is also a CBR1 inhibitor.
    Miquelianin (Standard)
  • HY-N1447R
    Ganoderic acid A (Standard)
    Ganoderic acid A (Standard) is the analytical standard of Ganoderic acid A. This product is intended for research and analytical applications. Ganoderic acid A can inhibit of the JAK-STAT3 signaling pathway, also inhibit proliferation, viability, ROS.
    Ganoderic acid A (Standard)
  • HY-110281R
    Dehydroascorbic acid (Standard)
    Dehydroascorbic acid (Standard) is the analytical standard of Dehydroascorbic acid. This product is intended for research and analytical applications. Dehydroascorbic acid, a blood-brain barrier transportable form of vitamin C, mediates potent cerebroprotection in experimental stroke.
    Dehydroascorbic acid (Standard)
  • HY-W015608R
    2-Phenylpropionic acid (Standard)
    2-Phenylpropionic acid (Standard) is the analytical standard of 2-Phenylpropionic acid. This product is intended for research and analytical applications. 2-Phenylpropionic acid is an intermediate in alpha-Methylstyrene metabolism.
    2-Phenylpropionic acid (Standard)
  • HY-W017511R
    5,6-Dimethyl-1H-benzo[d]imidazole (Standard)
    5,6-Dimethyl-1H-benzo[d]imidazole (Standard) is the analytical standard of 5,6-Dimethyl-1H-benzo[d]imidazole (HY-W017511). This product is intended for research and analytical applications. 5,6-Dimethyl-1H-benzo[d]imidazole is an endogenous metabolite. 5,6-Dimethyl-1H-benzo[d]imidazole is also a benzimidazole derivative and can be used in the synthesis of other active compounds.
    5,6-Dimethyl-1H-benzo[d]imidazole (Standard)
  • HY-B0442C
    Vardenafil dihydrochloride
    Vardenafil dihydrochloride is a selective and orally active inhibitor of phosphodiesterase-5 (PDE5), with an IC50 of 0.7 nM. Vardenafil dihydrochloride shows inhibitory towards PDE1, PDE6 with IC50s of 180 nM, and 11 nM respectively, while IC50s are >1000 nM for PDE3 and PDE4. Vardenafil dihydrochloride competitively inhibits cyclic guanosine monophosphate (cGMP) hydrolysis and thus increases cGMP levels. Vardenafil dihydrochloride can be used for the research of erectile dysfunction, hepatitis, diabetes-.
    Vardenafil dihydrochloride
  • HY-B0143A
    Niacin hydrochloride
    Niacin (Vitamin B3; Nicotinic acid) hydrochloride is an orally active B3 vitamin that is an essential nutrient for humans. Niacin hydrochloride plays a key role in energy metabolism, cell signaling cascades regulating gene expression and apoptosis. Niacin hydrochloride is also used in the study of cardiovascular diseases.
    Niacin hydrochloride
  • HY-78036R
    Mesaconic acid (Standard)
    Mesaconic acid (Standard) is the analytical standard of Mesaconic acid. This product is intended for research and analytical applications. Mesaconic acid is an active product that can be extracted from Saxifraga stolonifera. Mesaconic acid is used as a fire retardant and is a competitive inhibitor of fumarate reduction[1].
    Mesaconic acid (Standard)
  • HY-P3494
    Hepcidin-25 (human)
    Hepcidin-25 (human) is an iron metabolism modulator. Hepcidin-25 (human) shows anti-inflammatory and anti-bacterial activity via modulation of iron-mediated oxidant injury.
    Hepcidin-25 (human)
  • HY-18252A
    Avanafil dibenzenesulfonate
    		Modulator
    Avanafil (TA-1790) dibenzenesulfonate is a potent and selective phosphodiesterase-5 (PDE-5) inhibitor with IC50 values of 5.2 nM, 630 nM, 5700 nM, 6200 nM, 12000 nM, 27000 nM, 51000 nM and 53000 nM for PDE-5, PDE-6, PDE-4, PDE-10, PDE-8, PDE-7, PDE-2 and PDE-1, respectively. Avanafil dibenzenesulfonate activates NO/cGMP/PKG signaling-pathway to decrease loss in BMD, bone atrophy, and oxidative stress. Avanafil dibenzenesulfonate inhibits cyclic guanosine monophosphate (cGMP) hydrolysis and thus increases cGMP levels. Avanafil dibenzenesulfonate can be used for the research of erectile dysfunction and osteoporosis.
    Avanafil dibenzenesulfonate
  • HY-B1232A
    Metyrapone Tartrate
    		Inhibitor
    Metyrapone (Su-4885) Tartrate is a potent and orally active 11β-hydroxylase inhibitor and an autophagy activator, also inhibits the production of aldosterone. Metyrapone Tartrate inhibits synthesis of endogenous adrenal corticosteroid, decreases glucocorticoid levels, and also affects behavior and emotion. In addition, Metyrapone Tartrate increases the efficiency of autophagic process via downregulation of mTOR pathway, and interacts with Pseudomonas putida cytochrome P-450. Metyrapone Tartrate can be used for researching Cushing's syndrome and depression.
    Metyrapone Tartrate
  • HY-W011303R
    Phytosphingosine (Standard)
    Phytosphingosine (Standard) is the analytical standard of Phytosphingosine. This product is intended for research and analytical applications. Phytosphingosine is a phospholipid with anti-inflammatory, antibacterial, and anti-cancer activities, which can induce apoptosis. Phytosphingosine is an immune regulator and can be used in the study of inflammatory skin diseases. Phytosphingosine is also an activator of GPR120 with an IC50 value of 33.4 μM and can be used in the study of type II diabetes[1][2][3][4].
    Phytosphingosine (Standard)
  • HY-13502B
    Mitoxantrone diacetate
    Mitoxantrone diacetate is a potent topoisomerase II inhibitor. Mitoxantrone diacetate also inhibits protein kinase C (PKC) activity with an IC50 of 8.5 μM. Mitoxantrone diacetate induces apoptosis of B-CLL (B-chronic lymphocytic leukaemia) cells. Mitoxantrone diacetate shows antitumor activity. Mitoxantrone diacetate also has anti-orthopoxvirus activity with EC50s of 0.25 μM and and 0.8 μM for cowpox and monkeypox, respectively.
    Mitoxantrone diacetate
  • HY-109051
    Arfolitixorin
    Arfolitixorin is a potent 5-Fluorouracil (5-FU) moderator. Arfolitixorin is an immediately active form of Folate, [6R]-5,10-methylenetetrahydrofolate ([6R]-MTHF). Arfolitixorin is potent for the research of metastatic colorectal cancer.
    Arfolitixorin
  • HY-109051C
    Arfolitixorin sulfate
    Arfolitixorin sulfate is a potent 5-Fluorouracil (5-FU) moderator. Arfolitixorin sulfate is an immediately active form of Folate, [6R]-5,10-methylenetetrahydrofolate ([6R]-MTHF). Arfolitixorin sulfate is potent for the research of metastatic colorectal cancer.
    Arfolitixorin sulfate
  • HY-B0511A
    Biotin sodium
    Biotin (Vitamin B7) sodium is a water-soluble B vitamin and serves as a coenzyme for five carboxylases in humans, involved in the synthesis of fatty acids, isoleucine, and valine, and in gluconeogenesis. Biotin sodium is necessary for cell growth, the production of fatty acids, and the metabolism of fats and amino acids.
    Biotin sodium
  • HY-W007704R
    Methyl cyclohexanecarboxylate (Standard)
    Methyl cyclohexanecarboxylate (Standard) is the analytical standard of Methyl cyclohexanecarboxylate. This product is intended for research and analytical applications. Methyl cyclohexanecarboxylate is an endogenous metabolite.
    Methyl cyclohexanecarboxylate (Standard)
Cat. No. Product Name / Synonyms Application Reactivity