2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Endogenous Metabolite

Endogenous Metabolite

Endogenous Metabolite

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Metabolite results when a drug is metabolized into a modified form which continues to produce effects. A metabolome in a given body fluid is influenced by endogenous factors such as age, sex, body composition and genetics as well as underlying pathologies.The levels of the enormous array of unique small-molecule metabolites are usually kept tightly regulated by the activity of a very large array of enzymes and transporters responsible for the production, transformation, degradation, and compartmentalization of these small molecules.The levels of the endogenous small molecules present in the brain are normally tightly regulated.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-108872S1
    Water-17O
    		≥99.0%
    Water-17O is the 17O labeled Water.
    Water-<sup>17</sup>O
  • HY-N0091S
    Hypoxanthine-13C5,15N4
    		≥99.0%
    Hypoxanthine-13C5,15N4 is a 15N-labeled and 13C-labled Hypoxanthine (HY-N0091). Hypoxanthine, a purine derivative, is a potential free radical generator and could be used as an indicator of hypoxia.
    Hypoxanthine-<sup>13</sup>C<sub>5</sub>,<sup>15</sup>N<sub>4</sub>
  • HY-D0889R
    Glycylglycine (Standard)
    Glycylglycine (Standard) is the analytical standard of Glycylglycine (HY-D0889). This product is intended for research and analytical applications. Glycylglycine is a non-selective glycylglycine dipeptidase substrate and iNOS inhibitor. Glycylglycine can cross the cell membrane by passive diffusion and is hydrolyzed to glycine in the cell, participating in energy metabolism and antioxidant processes. Glycylglycine promotes spermatogonial stem cells (SSCs) proliferation, inhibits astrocyte overactivation and reduces nitric oxide (NO) release, while upregulating the expression of neurotrophic factors (such as PDGFA, FGF2, CNTF) to support nerve myelin repair. Glycylglycine can be used to study male reproductive biology (such as SSCs proliferation regulation) and neurodegenerative diseases (such as neuroprotective mechanisms in multiple sclerosis).
    Glycylglycine (Standard)
  • HY-Y1373S1
    Cyclohexanecarboxylic acid-d11
    		99.14%
    Cyclohexanecarboxylic acid-d11 is the deuterium labeled Cyclohexanecarboxylic acid. Cyclohexanecarboxylic acid is a Valproate structural analogue with anticonvulsant action.
    Cyclohexanecarboxylic acid-d<sub>11</sub>
  • HY-167862
    UCM-05194
    UCM-05194 is a selective LPA1 receptor agonist with activity to improve neuropathic pain. UCM-05194 is a LPA1 agonist that exhibits potent and selective properties in its pharmacologically similar properties. UCM-05194 triggers LPA1-mediated cellular effects and leads to internalization of the receptor, resulting in functional inactivation in primary sensory neurons. UCM-05194 effectively reduces pain perception in in vivo models. UCM-05194 can be used to conduct research on progressive systemic diseases.
    UCM-05194
  • HY-W013854
    5α-Androstan-3β-ol
    		98.00%
    5α-Androstan-3β-ol (Androstan), a saturated sterol, is a CAR (constitutive androstane receptor) inverse agonist ligand. 5α-Androstan-3β-ol (Androstan) increases the AmB-channel conductance in a concentration dependent manner.
    5α-Androstan-3β-ol
  • HY-W012480S
    DL-Tryptophan-d3
    		99.29%
    DL-Tryptophan-d3 is the deuterium labeled DL-Tryptophan. DL-Tryptophan is an endogenous metabolite.
    DL-Tryptophan-d<sub>3</sub>
  • HY-B1779R
    Sucrose (Standard)
    Sucrose (Standard) is the analytical standard of Sucrose. This product is intended for research and analytical applications. Sucrose (D-(+)-Saccharose) is a disaccharide which is composed of two monosaccharides, glucose and fructose. Sucrose?can be applied in some animal models, including metabolic disease, obesity,?diet on preference,?and diabetes, et al.
    Sucrose (Standard)
  • HY-U00264
    2-γ-Linolenoyl-1,3-dilinoleoyl-sn-glycerol
    		≥99.0%
    2-γ-Linolenoyl-1,3-dilinoleoyl-sn-glycerol is a triglyceride.
    2-γ-Linolenoyl-1,3-dilinoleoyl-sn-glycerol
  • HY-W040329R
    2'-Deoxyadenosine (Standard)
    2'-Deoxyadenosine (Standard) is the analytical standard of 2'-Deoxyadenosine (HY-W040329). This product is intended for research and analytical applications. 2′-Deoxyadenosine is an adenine nucleoside that inhibits glucose-stimulated insulin release. 2′-Deoxyadenosine inhibits glucose-stimulated increases seen in islet cyclic AMP (cAMP) accumulation. 2'-Deoxyadenosine activates caspase-3 and promotes apoptosis. 2'-Deoxyadenosine inhibits the activity of S-adenosyl-L-homocysteine hydrolase (SAHH). 2'-Deoxyadenosine inhibits the growth of various cells. 2'-Deoxyadenosine has an anticancer effect on colon cancer.
    2'-Deoxyadenosine (Standard)
  • HY-B1899S1
    Taurodeoxycholic acid-d4
    		99.40%
    Taurodeoxycholic acid-d4 is the deuterium labeled Taurodeoxycholic acid.
    Taurodeoxycholic acid-d<sub>4</sub>
  • HY-D0845R
    Nitrosoglutathione (Standard)
    Nitrosoglutathione (Standard) (GSNO (Standard)) is the analytical standard of Nitrosoglutathione (HY-D0845). This product is intended for research and analytical applications. Nitrosoglutathione (GSNO), a exogenous NO donor and a substrate for rat alcohol dehydrogenase class III isoenzyme, inhibits cerebrovascular angiotensin II-dependent and -independent AT1 receptor responses. x
    Nitrosoglutathione (Standard)
  • HY-113360
    Chenodeoxycholic acid 3-sulfate
    Chenodeoxycholic acid 3-sulfate is a bile acid. Chenodeoxycholic acid 3-sulfate level corresponds closely with the extent of hepatic dysfunction.
    Chenodeoxycholic acid 3-sulfate
  • HY-B0275AR
    Oxytetracycline hydrochloride (Standard)
    Oxytetracycline (hydrochloride) (Standard) is the analytical standard of Oxytetracycline (hydrochloride). This product is intended for research and analytical applications. Oxytetracycline hydrochloride is an antibiotic belonging to the tetracycline class. Oxytetracycline hydrochloride potent inhibits Gram-negative and Gram-positive bacteria. Oxytetracycline hydrochloride is a protein synthesis inhibitor and prevents the binding from aminoacil-tRNA to the complex m-ribosomal RNA. Oxytetracycline hydrochloride also possesses anti-HSV-1 activity.
    Oxytetracycline hydrochloride (Standard)
  • HY-N1132AR
    D-(+)-Trehalose dihydrate (Standard)
    D-(+)-Trehalose dihydrate (Standard) is the analytical standard of D-(+)-Trehalose dihydrate. This product is intended for research and analytical applications. D-(+)-Trehalose dihydrate, isolated from Saccharomyces cerevisiae, can be used as a food ingredient and pharmaceutical excipient.
    D-(+)-Trehalose dihydrate (Standard)
  • HY-138877
    Phosphoglycolic acid
    		99.80%
    Phosphoglycolic acid intricately connects photo-respiration to central metabolism, influencing the tissue content of 2-phospho-glycolate.
    Phosphoglycolic acid
  • HY-164091A
    Mevalonate 5-phosphate trilithium
    		≥99.0%
    Mevalonate 5-phosphate trilithium is a substrate of phosphomevalonate kinase and mevalonate-5-phosphate decarboxylase.
    Mevalonate 5-phosphate trilithium
  • HY-125385
    Sulforhodamine 101 DHPE
    Sulforhodamine 101 DHPE is a fluorescent probe made from the conjugation of the phospholipid 1,2-dipalmitoyl-sn-glycero-3-PE to sulforhodamine 101, a red fluorescent dye that displays excitation/emission spectra of 586/605 nm, respectively. It integrates into phospholipid bilayers and has been used for imaging of solid supported lipid bilayers, detection of protein-ligand binding on bilayers, and to monitor colocalization of lipid probes in liposomes via resonance energy transfer (RET).
    Sulforhodamine 101 DHPE
  • HY-107494
    13-cis-4-Oxoretinoic acid
    13-cis-4-Oxoretinoic acid (4-Keto 13-cis-retinoic acid) is a metabolite of vitamin A in human plasma.
    13-cis-4-Oxoretinoic acid
  • HY-17556R
    Folinic acid (Standard)
    Folinic acid (Standard) is the analytical standard of Folinic acid. This product is intended for research and analytical applications. Folinic acid (Leucovorin) is a biological folic acid and is generally administered along with Methotrexate (MTX) (HY-14519) as a rescue agent to decrease MTX-induced toxicity.
    Folinic acid (Standard)
Cat. No. Product Name / Synonyms Application Reactivity